{"id":54441,"date":"2001-11-01T00:00:00","date_gmt":"2018-12-04T05:43:40","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/relation-between-dietary-linolenic-acid-and-coronary-artery\/"},"modified":"2018-12-04T06:43:40","modified_gmt":"2018-12-04T05:43:40","slug":"relation-between-dietary-linolenic-acid-and-coronary-artery","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/relation-between-dietary-linolenic-acid-and-coronary-artery\/","title":{"rendered":"Relation between dietary linolenic acid and coronary artery disease in the National Heart, Lung, and Blood Institute Family Heart Study."},"content":{"rendered":"<p><strong>BACKGROUND:<\/strong><br \/>\nEpidemiologic studies suggest that a higher consumption of eicosapentaenoic acid and docosahexaenoic acid is associated with a reduced risk of cardiovascular disease. Studies in humans and animals also reported an inverse association between alpha-linolenic acid and cardiovascular disease morbidity and mortality.<\/p>\n<p><strong>OBJECTIVE:<\/strong><br \/>\nWe examined the relation between dietary linolenic acid and prevalent coronary artery disease (CAD).<\/p>\n<p><strong>DESIGN:<\/strong><br \/>\nWe studied 4584 participants with a mean (+\/-SD) age of 52.1 +\/- 13.7 y in the National Heart, Lung, and Blood Institute Family Heart Study in a cross-sectional design. Participants&#039; diets were assessed with a semiquantitative food-frequency questionnaire. For each sex, we created age- and energy-adjusted quintiles of linolenic acid, and we used logistic regression to estimate prevalent odds ratios for CAD.<\/p>\n<p><strong>RESULTS:<\/strong><br \/>\nFrom the lowest to the highest quintile of linolenic acid, the prevalence odds ratios of CAD were 1.0, 0.77, 0.61, 0.58, and 0.60 for the men (P for trend = 0.012) and 1.0, 0.57, 0.52, 0.30, and 0.42 for the women (P for trend = 0.014) after adjustment for age, linoleic acid, and anthropometric, lifestyle, and metabolic factors. Linoleic acid was also inversely related to the prevalence odds ratios of CAD in the multivariate model (0.60 and 0.61 in the second and third tertiles, respectively) after adjustment for linolenic acid. The combined effect of linoleic and linolenic acids was stronger than the individual effects of either fatty acid.<\/p>\n<p><strong>CONCLUSIONS:<\/strong><br \/>\nA higher intake of either linolenic or linoleic acid was inversely related to the prevalence odds ratio of CAD. The 2 fatty acids had synergistic effects on the prevalence odds ratio of CAD.<\/p>\n","protected":false},"template":"","mots_cles":[225],"class_list":["post-54441","resume","type-resume","status-publish","hentry","mots_cles-prevention"],"acf":{"adresse":"\"DJOUSSE L,BOSTON UNIV,SCH MED PREVENT MED & EPIDEMIOL SECT EVANS DEPT MED;ROOM B-612,715 ALBANY ST; BOSTON MA 02118, USA. ldjousse@bu.edu \"","annee":"2001","mois":"11","numero":"74:5","page":"612-619","auteurs":[{"ID":53767,"post_author":"0","post_date":"2018-12-04 06:24:55","post_date_gmt":"2018-12-04 05:24:55","post_content":"","post_title":"Folsom","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"folsom","to_ping":"","pinged":"","post_modified":"2018-12-04 06:24:55","post_modified_gmt":"2018-12-04 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04:34:57","post_content":"","post_title":"Hopkins","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"hopkins-3","to_ping":"","pinged":"","post_modified":"2018-12-04 05:34:57","post_modified_gmt":"2018-12-04 04:34:57","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/hopkins-3\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":54440,"post_author":"0","post_date":"2018-12-04 06:43:39","post_date_gmt":"2018-12-04 05:43:39","post_content":"","post_title":"Pankow","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"pankow","to_ping":"","pinged":"","post_modified":"2018-12-04 06:43:39","post_modified_gmt":"2018-12-04 05:43:39","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/pankow\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":51781,"post_author":"0","post_date":"2018-12-04 05:44:10","post_date_gmt":"2018-12-04 04:44:10","post_content":"","post_title":"Province","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"province","to_ping":"","pinged":"","post_modified":"2018-12-04 05:44:10","post_modified_gmt":"2018-12-04 04:44:10","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/province\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":44192,"post_author":"0","post_date":"2018-12-04 03:19:18","post_date_gmt":"2018-12-04 02:19:18","post_content":"","post_title":"AMERICAN JOURNAL OF CLINICAL NUTRITION","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"american-journal-of-clinical-nutrition","to_ping":"","pinged":"","post_modified":"2018-12-04 03:19:18","post_modified_gmt":"2018-12-04 02:19:18","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/american-journal-of-clinical-nutrition\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Relation between dietary linolenic acid and coronary artery disease in the National Heart, Lung, and Blood Institute Family Heart Study. - Aprifel<\/title>\n<meta name=\"description\" content=\"Relation between dietary linolenic acid and coronary artery disease in the National Heart, Lung, and Blood Institute Family Heart 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