{"id":54398,"date":"2003-01-01T00:00:00","date_gmt":"2018-12-04T05:42:07","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/plasma-homocysteine-concentration-is-decreased-by-dietary\/"},"modified":"2018-12-04T06:42:07","modified_gmt":"2018-12-04T05:42:07","slug":"plasma-homocysteine-concentration-is-decreased-by-dietary","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/plasma-homocysteine-concentration-is-decreased-by-dietary\/","title":{"rendered":"Plasma homocysteine concentration is decreased by dietary intervention"},"content":{"rendered":"

High plasma total homocysteine (tHcy) concentration is reported to be a risk factor for vascular diseases. We investigated the extent to which serum folate and plasma tHcy respond to a high intake of natural folate from food. Thirty-seven healthy females volunteered to participate in a crossover dietary intervention. The study included a baseline period and two 5-week diet periods (low- and high-folate diets) with a 3-week washout in between. The low-folate diet contained one serving of both vegetables and fruit\/d, while during the high-folate diet the subjects ate at least seven servings of vegetables, berries, and citrus fruit\/d. Serum and erythrocyte (RBC) folate, serum vitamin B-12, and plasma tHcy concentrations were measured at the baseline and at the end of each diet period. The mean concentrations of serum and RBC folate were 11.0 (sd 3.0) nmol\/l and 412 (sd 120) nmol\/l at the end of the low-folate diet and 78 (95 % CI 62, 94) % and 14 (95 % CI 8, 20) % higher in response to the high-folate diet (P<0.001). The serum concentration of vitamin B-12 remained unchanged during the intervention. The mean plasma tHcy concentration was 8.0 \u00b5mol\/l at the end of the low-folate diet and decreased by 13 (95 % CI 9, 18) % in response to the high-folate diet (P<0.001). In conclusion, a diet high in fresh berries, citrus fruit, and vegetables effectively increases serum and RBC folate and decreases plasma homocysteine. Reprints:<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-54398","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"\"SILASTE ML,UNIV OULU,DEPT INTERNAL MED;KAJAANINTIE 50,POB 5000;FIN-90014 OULU, FINLAND.Marja-Leena.Silaste@oulu.fi \"","annee":"2003","mois":"0","numero":"89:3","page":"295-301","auteurs":[{"ID":52481,"post_author":"0","post_date":"2018-12-04 06:03:29","post_date_gmt":"2018-12-04 05:03:29","post_content":"","post_title":"Georg Alfthan","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"georg-alfthan","to_ping":"","pinged":"","post_modified":"2018-12-04 06:03:29","post_modified_gmt":"2018-12-04 05:03:29","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/georg-alfthan\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":53024,"post_author":"0","post_date":"2018-12-04 06:12:45","post_date_gmt":"2018-12-04 05:12:45","post_content":"","post_title":"Del Caro","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"del-caro","to_ping":"","pinged":"","post_modified":"2018-12-04 06:12:45","post_modified_gmt":"2018-12-04 05:12:45","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/del-caro\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":52482,"post_author":"0","post_date":"2018-12-04 06:03:30","post_date_gmt":"2018-12-04 05:03:30","post_content":"","post_title":"Kesaniemi","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"kesaniemi","to_ping":"","pinged":"","post_modified":"2018-12-04 06:03:30","post_modified_gmt":"2018-12-04 05:03:30","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/kesaniemi\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":52483,"post_author":"0","post_date":"2018-12-04 06:03:31","post_date_gmt":"2018-12-04 05:03:31","post_content":"","post_title":"Rantala","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"rantala","to_ping":"","pinged":"","post_modified":"2018-12-04 06:03:31","post_modified_gmt":"2018-12-04 05:03:31","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/rantala\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":52484,"post_author":"0","post_date":"2018-12-04 06:03:32","post_date_gmt":"2018-12-04 05:03:32","post_content":"","post_title":"Silaste","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"silaste","to_ping":"","pinged":"","post_modified":"2018-12-04 06:03:32","post_modified_gmt":"2018-12-04 05:03:32","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/silaste\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":41686,"post_author":"0","post_date":"2018-12-04 02:36:48","post_date_gmt":"2018-12-04 01:36:48","post_content":"","post_title":"BRITISH JOURNAL OF NUTRITION","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"british-journal-of-nutrition","to_ping":"","pinged":"","post_modified":"2018-12-04 02:36:48","post_modified_gmt":"2018-12-04 01:36:48","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/british-journal-of-nutrition\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"\nPlasma homocysteine concentration is decreased by dietary intervention - 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