{"id":54322,"date":"2000-01-01T00:00:00","date_gmt":"2018-12-04T05:39:21","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/cancer-and-ageing-rival-demons\/"},"modified":"2018-12-04T06:39:21","modified_gmt":"2018-12-04T05:39:21","slug":"cancer-and-ageing-rival-demons","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/cancer-and-ageing-rival-demons\/","title":{"rendered":"Cancer and ageing: rival demons?"},"content":{"rendered":"

Organisms with renewable tissues use a network of genetic pathways and cellular responses to prevent cancer. The main mammalian tumour-suppressor pathways evolved from ancient mechanisms that, in simple post-mitotic organisms, act predominantly to regulate embryogenesis or to protect the germline. The shift from developmental and\/or germline maintenance in simple organisms to somatic maintenance in complex organisms might have evolved at a cost. Recent evidence indicates that some mammalian tumour-suppressor mechanisms contribute to ageing. How might this have happened, and what are its implications for our ability to control cancer and ageing?<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-54322","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"\"CAMPISI J,UNIV CALIF BERKELEY,LAWRENCE BERKELEY LAB DIV LIFE SCI;1 CYCLOTRON RD; BERKELEY CA 94720, USA.jcampisi@lbl.gov \"","annee":"0","mois":"0","numero":"3(5)","page":"339-349","auteurs":[{"ID":45549,"post_author":"0","post_date":"2018-12-04 03:43:19","post_date_gmt":"2018-12-04 02:43:19","post_content":"","post_title":"Campisi","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"campisi","to_ping":"","pinged":"","post_modified":"2018-12-04 03:43:19","post_modified_gmt":"2018-12-04 02:43:19","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/campisi\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":54321,"post_author":"0","post_date":"2018-12-04 06:39:20","post_date_gmt":"2018-12-04 05:39:20","post_content":"","post_title":"NATURE REVIEWS CANCER","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"nature-reviews-cancer","to_ping":"","pinged":"","post_modified":"2018-12-04 06:39:20","post_modified_gmt":"2018-12-04 05:39:20","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/nature-reviews-cancer\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"\nCancer and ageing: rival demons? 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