{"id":54126,"date":"2003-06-01T00:00:00","date_gmt":"2018-12-04T05:32:34","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/effect-of-five-year-supplementation-of-vitamin-c-on-serum-vitamin\/"},"modified":"2018-12-04T06:32:34","modified_gmt":"2018-12-04T05:32:34","slug":"effect-of-five-year-supplementation-of-vitamin-c-on-serum-vitamin","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/effect-of-five-year-supplementation-of-vitamin-c-on-serum-vitamin\/","title":{"rendered":"Effect of five-year supplementation of vitamin c on serum vitamin c concentration and consumption of vegetables and fruits in middle-aged japanese: a randomized controlled trial."},"content":{"rendered":"<p>OBJECTIVE: This study was aimed at evaluating the effect of long-term vitamin C supplementation on serum and dietary vitamin C and identifying the factors associated with change in serum concentration. METHODS: A total of 439 subjects with atrophic gastritis initially participated in a randomized clinical trial using vitamin C and beta-carotene to prevent gastric cancer. We originally randomized the participants into four treatment groups using a 2&#215;2 factorial design, whereby 0 or 15 mg\/day beta-carotene and 50 or 500 mg\/day vitamin C were administered in a double-blind manner. The beta-carotene component was terminated early after a mean treatment duration of four months. Before and upon early termination of beta-carotene supplementation, 134 subjects dropped out this trial, while 120 and 124 subjects took the vitamin C supplement at either 50 mg or 500 mg daily for five years. RESULTS: Changes in serum vitamin C were significantly higher in the high-dose group (38.5% increase, 95% CI = 27.0-49.9) than in the low-dose group (13.0% increase, 5.1-20.9) or in the dropout group (3.3% increase, -2.1-8.6) after five-year supplementation. The serum vitamin C at baseline was negatively associated with changes in serum vitamin C (p &lt; 0.0001), while high-dose (p &lt; 0.0001) and low-dose (p &lt; 0.05) supplementation and female gender (p &lt; 0.001) were positively associated. Dietary intake of vitamin C in the supplementation group was almost identical before and after five-year supplementation of vitamin C (2.31 mg\/day decrease, 95% CI = -15.3-10.7), while a 17.7 mg\/day decrease (95% CI = -44.2-8.86) was observed in the drop-out group. CONCLUSION: Five-year vitamin C supplementation induces a remarkable increase in serum vitamin C concentration, and our intervention program appears to have no effect on dietary vitamin C intake.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-54126","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Epidemiology & Biostatistics Division, National Cancer Center Research Institute East, Chiba, Japan. stsugane@east.ncc.go.jp","annee":"2003","mois":"6","numero":"22:3","page":"208-216","auteurs":[{"ID":6679,"post_author":"0","post_date":"2018-12-03 17:40:44","post_date_gmt":"2018-12-03 16:40:44","post_content":"","post_title":"Shoichiro Tsugane","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"shoichiro-tsugane","to_ping":"","pinged":"","post_modified":"2018-12-03 17:40:44","post_modified_gmt":"2018-12-03 16:40:44","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/shoichiro-tsugane\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":13532,"post_author":"0","post_date":"2018-12-03 18:59:17","post_date_gmt":"2018-12-03 17:59:17","post_content":"","post_title":"Shizuka Sasazuki","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"shizuka-sasazuki","to_ping":"","pinged":"","post_modified":"2018-12-03 18:59:17","post_modified_gmt":"2018-12-03 17:59:17","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/shizuka-sasazuki\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":9602,"post_author":"0","post_date":"2018-12-03 18:13:01","post_date_gmt":"2018-12-03 17:13:01","post_content":"","post_title":"Satoshi Sasaki","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"satoshi-sasaki","to_ping":"","pinged":"","post_modified":"2018-12-03 18:13:01","post_modified_gmt":"2018-12-03 17:13:01","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/satoshi-sasaki\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":9029,"post_author":"0","post_date":"2018-12-03 18:06:34","post_date_gmt":"2018-12-03 17:06:34","post_content":"","post_title":"Mi Kyung Kim","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"mi-kyung-kim","to_ping":"","pinged":"","post_modified":"2018-12-03 18:06:34","post_modified_gmt":"2018-12-03 17:06:34","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/mi-kyung-kim\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":49273,"post_author":"0","post_date":"2018-12-04 04:54:06","post_date_gmt":"2018-12-04 03:54:06","post_content":"","post_title":"Hayashi","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"hayashi-3","to_ping":"","pinged":"","post_modified":"2018-12-04 04:54:06","post_modified_gmt":"2018-12-04 03:54:06","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/hayashi-3\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":49274,"post_author":"0","post_date":"2018-12-04 04:54:07","post_date_gmt":"2018-12-04 03:54:07","post_content":"","post_title":"Okubo","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"okubo","to_ping":"","pinged":"","post_modified":"2018-12-04 04:54:07","post_modified_gmt":"2018-12-04 03:54:07","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/okubo\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":46381,"post_author":"0","post_date":"2018-12-04 03:56:53","post_date_gmt":"2018-12-04 02:56:53","post_content":"","post_title":"JOURNAL OF AMERICAN COLLEGE OF NUTRITION","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"journal-of-american-college-of-nutrition","to_ping":"","pinged":"","post_modified":"2018-12-04 03:56:53","post_modified_gmt":"2018-12-04 02:56:53","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/journal-of-american-college-of-nutrition\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Effect of five-year supplementation of vitamin c on serum vitamin c concentration and consumption of vegetables and fruits in middle-aged japanese: a randomized controlled trial. - Aprifel<\/title>\n<meta name=\"description\" content=\"Effect of five-year supplementation of vitamin c on serum vitamin c concentration and consumption of vegetables and fruits in middle-aged japanese: a randomized controlled trial. - Aprifel\" \/>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Effect of five-year supplementation of vitamin c on serum vitamin c concentration and consumption of vegetables and fruits in middle-aged japanese: a randomized controlled trial.\" \/>\n<meta property=\"og:description\" content=\"Effect of five-year supplementation of vitamin c on serum vitamin c concentration and consumption of vegetables and fruits in middle-aged japanese: a randomized controlled trial.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/effect-of-five-year-supplementation-of-vitamin-c-on-serum-vitamin\/\" \/>\n<meta property=\"og:site_name\" content=\"Aprifel\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/effect-of-five-year-supplementation-of-vitamin-c-on-serum-vitamin\/\",\"url\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/effect-of-five-year-supplementation-of-vitamin-c-on-serum-vitamin\/\",\"name\":\"Effect of five-year supplementation of vitamin c on serum vitamin c concentration and consumption of vegetables and fruits in middle-aged japanese: a randomized controlled trial. - Aprifel\",\"isPartOf\":{\"@id\":\"https:\/\/www.aprifel.com\/fr\/#website\"},\"datePublished\":\"2018-12-04T05:32:34+00:00\",\"dateModified\":\"2018-12-04T05:32:34+00:00\",\"description\":\"Effect of five-year supplementation of vitamin c on serum vitamin c concentration and consumption of vegetables and fruits in middle-aged japanese: a randomized controlled trial. - Aprifel\",\"breadcrumb\":{\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/effect-of-five-year-supplementation-of-vitamin-c-on-serum-vitamin\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/effect-of-five-year-supplementation-of-vitamin-c-on-serum-vitamin\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/effect-of-five-year-supplementation-of-vitamin-c-on-serum-vitamin\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/www.aprifel.com\/fr\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"R\u00e9sum\u00e9s\",\"item\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Effect of five-year supplementation of vitamin c on serum vitamin c concentration and consumption of vegetables and fruits in middle-aged japanese: a randomized controlled trial.\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.aprifel.com\/fr\/#website\",\"url\":\"https:\/\/www.aprifel.com\/fr\/\",\"name\":\"Aprifel\",\"description\":\"Agence pour la Recherche et l\u2019Information en Fruits et L\u00e9gumes\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.aprifel.com\/fr\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Effect of five-year supplementation of vitamin c on serum vitamin c concentration and consumption of vegetables and fruits in middle-aged japanese: a randomized controlled trial. - Aprifel","description":"Effect of five-year supplementation of vitamin c on serum vitamin c concentration and consumption of vegetables and fruits in middle-aged japanese: a randomized controlled trial. - Aprifel","robots":{"index":"noindex","follow":"follow"},"og_locale":"fr_FR","og_type":"article","og_title":"Effect of five-year supplementation of vitamin c on serum vitamin c concentration and consumption of vegetables and fruits in middle-aged japanese: a randomized controlled trial.","og_description":"Effect of five-year supplementation of vitamin c on serum vitamin c concentration and consumption of vegetables and fruits in middle-aged japanese: a randomized controlled trial.","og_url":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/effect-of-five-year-supplementation-of-vitamin-c-on-serum-vitamin\/","og_site_name":"Aprifel","twitter_card":"summary_large_image","twitter_misc":{"Dur\u00e9e de lecture estim\u00e9e":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/effect-of-five-year-supplementation-of-vitamin-c-on-serum-vitamin\/","url":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/effect-of-five-year-supplementation-of-vitamin-c-on-serum-vitamin\/","name":"Effect of five-year supplementation of vitamin c on serum vitamin c concentration and consumption of vegetables and fruits in middle-aged japanese: a randomized controlled trial. - Aprifel","isPartOf":{"@id":"https:\/\/www.aprifel.com\/fr\/#website"},"datePublished":"2018-12-04T05:32:34+00:00","dateModified":"2018-12-04T05:32:34+00:00","description":"Effect of five-year supplementation of vitamin c on serum vitamin c concentration and consumption of vegetables and fruits in middle-aged japanese: a randomized controlled trial. - Aprifel","breadcrumb":{"@id":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/effect-of-five-year-supplementation-of-vitamin-c-on-serum-vitamin\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/effect-of-five-year-supplementation-of-vitamin-c-on-serum-vitamin\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/effect-of-five-year-supplementation-of-vitamin-c-on-serum-vitamin\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/www.aprifel.com\/fr\/"},{"@type":"ListItem","position":2,"name":"R\u00e9sum\u00e9s","item":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/"},{"@type":"ListItem","position":3,"name":"Effect of five-year supplementation of vitamin c on serum vitamin c concentration and consumption of vegetables and fruits in middle-aged japanese: a randomized controlled trial."}]},{"@type":"WebSite","@id":"https:\/\/www.aprifel.com\/fr\/#website","url":"https:\/\/www.aprifel.com\/fr\/","name":"Aprifel","description":"Agence pour la Recherche et l\u2019Information en Fruits et L\u00e9gumes","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.aprifel.com\/fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"}]}},"_links":{"self":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/resume\/54126"}],"collection":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/resume"}],"about":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/types\/resume"}],"wp:attachment":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/media?parent=54126"}],"wp:term":[{"taxonomy":"mots_cles","embeddable":true,"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/mots_cles?post=54126"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}