{"id":54097,"date":"2003-06-01T00:00:00","date_gmt":"2018-12-04T05:31:31","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/differential-effects-of-quercetin-and-resveratrol-on-band\/"},"modified":"2018-12-04T06:31:31","modified_gmt":"2018-12-04T05:31:31","slug":"differential-effects-of-quercetin-and-resveratrol-on-band","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/differential-effects-of-quercetin-and-resveratrol-on-band\/","title":{"rendered":"Differential effects of quercetin and resveratrol on band 3 tyrosine phosphorylation signalling of red blood cells."},"content":{"rendered":"

The protective effects of eating fruits and vegetables in the prevention of several degenerative pathologies have been attributed at least in part to the antioxidant and anti-inflammatory properties of polyphenols. In this study, we investigated the effects of two polyphenols, quercetin and resveratrol, on red blood cell Band 3 tyrosine phosphorylation signalling activated by peroxynitrite. Peroxynitrite is a physiological oxidant scavenged largely by the erythrocyte and formed by the reaction between nitrogen monoxide and superoxide anion. Quercetin and its structurally analogous (+)-catechin inhibited the peroxynitrite-dependent upregulation of Band 3 tyrosine phosphorylation. Quercetin was found to downregulate the activity of syk, which is upstream in the Band 3 tyrosine phosphorylation cascade, and partially prevented peroxynitrite-mediated phosphotyrosine phosphatase inhibition. Resveratrol and hydroxytyrosol, unexpectedly, amplified peroxynitrite-dependent upregulation of Band 3 tyrosine phosphorylation through the activation of lyn, a kinase of the src family. The present results clearly indicate that polyphenols may activate cell transduction pathways in different and sometimes opposite ways.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-54097","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Cell Biology Department, Istituto Superiore di Sanita, Viale Regina Elena, 299-00161 Rome, Italy.","annee":"2003","mois":"6","numero":"305:3","page":"541-547","auteurs":[{"ID":54094,"post_author":"0","post_date":"2018-12-04 06:31:27","post_date_gmt":"2018-12-04 05:31:27","post_content":"","post_title":"Maccaglia","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"maccaglia","to_ping":"","pinged":"","post_modified":"2018-12-04 06:31:27","post_modified_gmt":"2018-12-04 05:31:27","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/maccaglia\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":54095,"post_author":"0","post_date":"2018-12-04 06:31:29","post_date_gmt":"2018-12-04 05:31:29","post_content":"","post_title":"Mallozzi","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"mallozzi","to_ping":"","pinged":"","post_modified":"2018-12-04 06:31:29","post_modified_gmt":"2018-12-04 05:31:29","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/mallozzi\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":54096,"post_author":"0","post_date":"2018-12-04 06:31:30","post_date_gmt":"2018-12-04 05:31:30","post_content":"","post_title":"Minetti","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"minetti","to_ping":"","pinged":"","post_modified":"2018-12-04 06:31:30","post_modified_gmt":"2018-12-04 05:31:30","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/minetti\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":49155,"post_author":"0","post_date":"2018-12-04 04:51:57","post_date_gmt":"2018-12-04 03:51:57","post_content":"","post_title":"BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"biochemical-and-biophysical-research-communications","to_ping":"","pinged":"","post_modified":"2018-12-04 04:51:57","post_modified_gmt":"2018-12-04 03:51:57","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/biochemical-and-biophysical-research-communications\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"\nDifferential effects of quercetin and resveratrol on band 3 tyrosine phosphorylation signalling of red blood cells. - 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