{"id":53528,"date":"2003-07-01T00:00:00","date_gmt":"2018-12-04T05:20:42","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/synthesis-of-isothiocyanate-derived-mercapturic-acids\/"},"modified":"2018-12-04T06:20:42","modified_gmt":"2018-12-04T05:20:42","slug":"synthesis-of-isothiocyanate-derived-mercapturic-acids","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/synthesis-of-isothiocyanate-derived-mercapturic-acids\/","title":{"rendered":"Synthesis of isothiocyanate-derived mercapturic acids."},"content":{"rendered":"<p>Twelve mercapturic acids derived from saturated and unsaturated aliphatic and aromatic isothiocyanates were synthesised, by adding isothiocyanate to a solution of N-acetyl-L-cysteine and sodium bicarbonate, in a typical yield of 77%. Isothiocyanates were synthesised first by adding the corresponding alkyl bromide to phthalimide potassium salt. The obtained N-alkyl-phthalimide was hydrazinolysed yielding the alkyl amine, which subsequently was reacted with thiophosgene yielding the isothiocyanate with an overall yield of 16%. Mercapturic acids in urine can serve as a biomarker of intake to determine the health promoting potential of isothiocyanates present in cruciferous vegetables.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-53528","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Department of Food and Food Supplement Analysis, TNO Nutrition and Food Research, P.O. Box 360, 3700 AJ, Zeist, The Netherlands. m.vermuelen@voeding.tno.nl","annee":"2003","mois":"7","numero":"38:7","page":"729-737","auteurs":[{"ID":51812,"post_author":"0","post_date":"2018-12-04 05:44:48","post_date_gmt":"2018-12-04 04:44:48","post_content":"","post_title":"Verhagen","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"verhagen","to_ping":"","pinged":"","post_modified":"2018-12-04 05:44:48","post_modified_gmt":"2018-12-04 04:44:48","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/verhagen\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":48425,"post_author":"0","post_date":"2018-12-04 04:33:41","post_date_gmt":"2018-12-04 03:33:41","post_content":"","post_title":"Vermeulen","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"vermeulen","to_ping":"","pinged":"","post_modified":"2018-12-04 04:33:41","post_modified_gmt":"2018-12-04 03:33:41","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/vermeulen\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":53525,"post_author":"0","post_date":"2018-12-04 06:20:41","post_date_gmt":"2018-12-04 05:20:41","post_content":"","post_title":"Chittenden","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"chittenden","to_ping":"","pinged":"","post_modified":"2018-12-04 06:20:41","post_modified_gmt":"2018-12-04 05:20:41","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/chittenden\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":53526,"post_author":"0","post_date":"2018-12-04 06:20:41","post_date_gmt":"2018-12-04 05:20:41","post_content":"","post_title":"Zwanenburg","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"zwanenburg","to_ping":"","pinged":"","post_modified":"2018-12-04 06:20:41","post_modified_gmt":"2018-12-04 05:20:41","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/zwanenburg\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":53527,"post_author":"0","post_date":"2018-12-04 06:20:42","post_date_gmt":"2018-12-04 05:20:42","post_content":"","post_title":"EUROPEAN JOURNAL OF MEDICAL RESEARCH","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"european-journal-of-medical-research","to_ping":"","pinged":"","post_modified":"2018-12-04 06:20:42","post_modified_gmt":"2018-12-04 05:20:42","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/european-journal-of-medical-research\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - 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