{"id":52615,"date":"2003-01-01T00:00:00","date_gmt":"2018-12-04T05:05:41","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/changes-in-plasma-and-oral-mucosal-lycopene-isomer-concentrations\/"},"modified":"2018-12-04T06:05:41","modified_gmt":"2018-12-04T05:05:41","slug":"changes-in-plasma-and-oral-mucosal-lycopene-isomer-concentrations","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/changes-in-plasma-and-oral-mucosal-lycopene-isomer-concentrations\/","title":{"rendered":"Changes in plasma and oral mucosal lycopene isomer concentrations in healthy adults consuming standard servings of processed tomato products."},"content":{"rendered":"<p>The consumption of tomato products is associated with a reduced risk of cardiovascular disease and several cancers. It is hypothesized that lycopene, the major carotenoid in tomato products, may mediate this relationship. We designed a study to examine changes in plasma and buccal mucosal cell (BMC) lycopene concentrations in healthy adults consuming standard daily servings of processed tomato products: spaghetti sauce, tomato soup, or vegetable juice. Thirty-six healthy subjects consumed a lycopene-free diet for 2 wk and were then assigned to one of three (n = 12) intervention groups consuming daily, single servings of sauce (21 mg lycopene per (1\/2) cup), soup (12 mg lycopene per 1 cup), or juice (17 mg lycopene per 8 oz) for 4 wk. Fasting blood and BMC samples were evaluated by high-performance liquid chromatography analysis for carotenoids and lycopene isomers. Total plasma lycopene concentrations (Mean +\/- SEM) decreased from 1.05 +\/- 0.07 to 0.54 +\/- 0.05 micromol\/l (49%, P &lt; 0.0001) during the 2-wk washout period. Following intervention, plasma lycopene concentrations increased significantly for those consuming sauce, soup, and juice (compared with washout baseline) to 2.08 (192%, P &lt; 0.0001), 0.91 (122%, P &lt; 0.0001), and 0.99 (92%, P &lt; 0.0001) micromol\/l, respectively. Plasma isomer concentrations show a 61:39 ratio of cis:all-trans at the start of the study. During the 2-wk washout the decrease in plasma all-trans-lycopene was greater than that for pooled cis isomers (70:30 cis:trans ratio, P &lt; 0.001). After 2 wk of dietary intervention isomer ratios returned to those observed at the start of the study. Total BMC lycopene concentrations did not significantly change during the brief washout. During the 4-wk intervention period, BMC total lycopene concentrations increased (P &lt; 0.005) by 165, 42, and 48% nmol\/mg protein for those consuming sauce, soup, and juice, respectively. This study demonstrates that plasma lycopene decreases by 50% after approximately 2 wk on a lycopene-free diet with a decrease in the ratio of all-trans compared with cis isomers. Single, daily servings of processed tomato products significantly increase blood and BMC lycopene for 2 wk. Additional studies of lycopene bioavailability, isomerization, metabolism, and bioactivity will provide greater insight into the potential health benefits suggested by epidemiological studies and laboratory investigations.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-52615","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Department of Food Sciences and Technology, Ohio State University, Columbus, OH 43210, USA.","annee":"2003","mois":"0","numero":"47:1","page":"48-56","auteurs":[{"ID":49522,"post_author":"0","post_date":"2018-12-04 04:58:23","post_date_gmt":"2018-12-04 03:58:23","post_content":"","post_title":"E L Giovannucci","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"e-l-giovannucci","to_ping":"","pinged":"","post_modified":"2018-12-04 04:58:23","post_modified_gmt":"2018-12-04 03:58:23","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/e-l-giovannucci\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":15529,"post_author":"0","post_date":"2018-12-03 19:27:42","post_date_gmt":"2018-12-03 18:27:42","post_content":"","post_title":"Steven J Schwartz","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"steven-j-schwartz","to_ping":"","pinged":"","post_modified":"2018-12-03 19:27:42","post_modified_gmt":"2018-12-03 18:27:42","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/steven-j-schwartz\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3182,"post_author":"0","post_date":"2018-12-03 17:03:03","post_date_gmt":"2018-12-03 16:03:03","post_content":"","post_title":"Steven K Clinton","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"steven-k-clinton","to_ping":"","pinged":"","post_modified":"2018-12-03 17:03:03","post_modified_gmt":"2018-12-03 16:03:03","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/steven-k-clinton\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":52612,"post_author":"0","post_date":"2018-12-04 06:05:39","post_date_gmt":"2018-12-04 05:05:39","post_content":"","post_title":"Allen","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"allen-4","to_ping":"","pinged":"","post_modified":"2018-12-04 06:05:39","post_modified_gmt":"2018-12-04 05:05:39","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/allen-4\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":52613,"post_author":"0","post_date":"2018-12-04 06:05:40","post_date_gmt":"2018-12-04 05:05:40","post_content":"","post_title":"Craft","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"craft","to_ping":"","pinged":"","post_modified":"2018-12-04 06:05:40","post_modified_gmt":"2018-12-04 05:05:40","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/craft\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":52614,"post_author":"0","post_date":"2018-12-04 06:05:41","post_date_gmt":"2018-12-04 05:05:41","post_content":"","post_title":"De Groff","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"de-groff","to_ping":"","pinged":"","post_modified":"2018-12-04 06:05:41","post_modified_gmt":"2018-12-04 05:05:41","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/de-groff\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":1760,"post_author":"0","post_date":"2018-12-03 16:02:19","post_date_gmt":"2018-12-03 15:02:19","post_content":"","post_title":"Nutrition and cancer","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"nutrition-and-cancer","to_ping":"","pinged":"","post_modified":"2018-12-03 16:02:19","post_modified_gmt":"2018-12-03 15:02:19","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/nutrition-and-cancer\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - 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