{"id":52520,"date":"2004-02-01T00:00:00","date_gmt":"2018-12-04T05:04:06","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/exon-5-polymorphisms-in-the-o6-alkylguanine-dna-alkyltransferase\/"},"modified":"2018-12-04T06:04:06","modified_gmt":"2018-12-04T05:04:06","slug":"exon-5-polymorphisms-in-the-o6-alkylguanine-dna-alkyltransferase","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/exon-5-polymorphisms-in-the-o6-alkylguanine-dna-alkyltransferase\/","title":{"rendered":"Exon 5 polymorphisms in the o6-alkylguanine dna alkyltransferase gene and lung cancer risk in non-smokers exposed to second-hand smoke."},"content":{"rendered":"<p>PURPOSE: The objective of the study was to examine the association of three exon 5 variants in the O(6)-alkylguanine DNA alkyltransferase (AGT) gene involved in the repair of the mutagenic DNA lesion O(6)-alkylguanine formed by nitrosamines, with lung cancer risk in never-smokers. EXPERIMENTAL DESIGN: Exon 5 of the AGT gene was sequenced in genomic DNA from 136 cases and 133 hospital- or population-based controls for whom questionnaire information on second-hand smoke and diet was available to determine the frequencies of the Gly(160)Arg, Ile(143)Val, and Lys(178)Arg variant alleles. RESULTS: No codon (160)Arg variant alleles were found in the study population. The codon (143)Val and (178)Arg variant alleles, present at allele frequencies of 0.07, showed 100% linkage. The odds ratio (OR) of lung cancer for these variant carriers was 2.05 [95% confidence interval (CI) 1.03-4.07]. The risk varied between the different lung cancer pathologies with an increased risk for adenocarcinoma (OR 2.67, 95% CI 1.21-5.87) or small cell carcinoma (OR 4.83, 95% CI 0.91-25.7) but not for squamous cell carcinoma (OR 1.07, 95% CI 0.27-4.18). Compared with individuals carrying the mutant alleles unexposed to second-hand smoke, the OR for exposed variant carriers was 1.95 (95% CI 0.53-1.15); a similar interaction, although not significative, was observed for low consumption of cruciferous vegetables and for green vegetables and tomatoes. CONCLUSIONS: These results point toward a role of AGT polymorphisms in lung cancer susceptibility among never-smokers, in particular among subjects exposed to environmental carcinogens.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-52520","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"International Agency of Research on Cancer, Lyon, France.","annee":"2004","mois":"2","numero":"13:2","page":"320-3","auteurs":[{"ID":38650,"post_author":"0","post_date":"2018-12-04 01:40:48","post_date_gmt":"2018-12-04 00:40:48","post_content":"","post_title":"Julia Hall","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"julia-hall","to_ping":"","pinged":"","post_modified":"2018-12-04 01:40:48","post_modified_gmt":"2018-12-04 00:40:48","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/julia-hall\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":4092,"post_author":"0","post_date":"2018-12-03 17:12:19","post_date_gmt":"2018-12-03 16:12:19","post_content":"","post_title":"Paolo Boffetta","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"paolo-boffetta","to_ping":"","pinged":"","post_modified":"2018-12-03 17:12:19","post_modified_gmt":"2018-12-03 16:12:19","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/paolo-boffetta\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":28759,"post_author":"0","post_date":"2018-12-03 23:10:33","post_date_gmt":"2018-12-03 22:10:33","post_content":"","post_title":"Eoin P Brennan","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"eoin-p-brennan","to_ping":"","pinged":"","post_modified":"2018-12-03 23:10:33","post_modified_gmt":"2018-12-03 22:10:33","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/eoin-p-brennan\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":52515,"post_author":"0","post_date":"2018-12-04 06:04:02","post_date_gmt":"2018-12-04 05:04:02","post_content":"","post_title":"Nyberg","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"nyberg","to_ping":"","pinged":"","post_modified":"2018-12-04 06:04:02","post_modified_gmt":"2018-12-04 05:04:02","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/nyberg\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":52516,"post_author":"0","post_date":"2018-12-04 06:04:03","post_date_gmt":"2018-12-04 05:04:03","post_content":"","post_title":"Benhamou","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"benhamou","to_ping":"","pinged":"","post_modified":"2018-12-04 06:04:03","post_modified_gmt":"2018-12-04 05:04:03","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/benhamou\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":52517,"post_author":"0","post_date":"2018-12-04 06:04:04","post_date_gmt":"2018-12-04 05:04:04","post_content":"","post_title":"Cohet","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"cohet","to_ping":"","pinged":"","post_modified":"2018-12-04 06:04:04","post_modified_gmt":"2018-12-04 05:04:04","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/cohet\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":52518,"post_author":"0","post_date":"2018-12-04 06:04:05","post_date_gmt":"2018-12-04 05:04:05","post_content":"","post_title":"Borel","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"borel-2","to_ping":"","pinged":"","post_modified":"2018-12-04 06:04:05","post_modified_gmt":"2018-12-04 05:04:05","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/borel-2\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":45041,"post_author":"0","post_date":"2018-12-04 03:35:58","post_date_gmt":"2018-12-04 02:35:58","post_content":"","post_title":"Mukeria","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"mukeria","to_ping":"","pinged":"","post_modified":"2018-12-04 03:35:58","post_modified_gmt":"2018-12-04 02:35:58","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/mukeria\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":52519,"post_author":"0","post_date":"2018-12-04 06:04:05","post_date_gmt":"2018-12-04 05:04:05","post_content":"","post_title":"Bruske-hohlefd","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"bruske-hohlefd","to_ping":"","pinged":"","post_modified":"2018-12-04 06:04:05","post_modified_gmt":"2018-12-04 05:04:05","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/bruske-hohlefd\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":1195,"post_author":"0","post_date":"2018-12-03 15:57:12","post_date_gmt":"2018-12-03 14:57:12","post_content":"","post_title":"CANCER EPIDEMIOLOGY, BIOMARKERS AND PREVENTION","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"cancer-epidemiology-biomarkers-and-prevention","to_ping":"","pinged":"","post_modified":"2018-12-03 15:57:12","post_modified_gmt":"2018-12-03 14:57:12","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/cancer-epidemiology-biomarkers-and-prevention\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Exon 5 polymorphisms in the o6-alkylguanine dna alkyltransferase gene and lung cancer risk in non-smokers exposed to second-hand smoke. - Aprifel<\/title>\n<meta name=\"description\" content=\"Exon 5 polymorphisms in the o6-alkylguanine dna alkyltransferase gene and lung cancer risk in non-smokers exposed to second-hand smoke. - Aprifel\" \/>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Exon 5 polymorphisms in the o6-alkylguanine dna alkyltransferase gene and lung cancer risk in non-smokers exposed to second-hand smoke.\" \/>\n<meta property=\"og:description\" content=\"Exon 5 polymorphisms in the o6-alkylguanine dna alkyltransferase gene and lung cancer risk in non-smokers exposed to second-hand smoke.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/exon-5-polymorphisms-in-the-o6-alkylguanine-dna-alkyltransferase\/\" \/>\n<meta property=\"og:site_name\" content=\"Aprifel\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/exon-5-polymorphisms-in-the-o6-alkylguanine-dna-alkyltransferase\/\",\"url\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/exon-5-polymorphisms-in-the-o6-alkylguanine-dna-alkyltransferase\/\",\"name\":\"Exon 5 polymorphisms in the o6-alkylguanine dna alkyltransferase gene and lung cancer risk in non-smokers exposed to second-hand smoke. - Aprifel\",\"isPartOf\":{\"@id\":\"https:\/\/www.aprifel.com\/fr\/#website\"},\"datePublished\":\"2018-12-04T05:04:06+00:00\",\"dateModified\":\"2018-12-04T05:04:06+00:00\",\"description\":\"Exon 5 polymorphisms in the o6-alkylguanine dna alkyltransferase gene and lung cancer risk in non-smokers exposed to second-hand smoke. - Aprifel\",\"breadcrumb\":{\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/exon-5-polymorphisms-in-the-o6-alkylguanine-dna-alkyltransferase\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/exon-5-polymorphisms-in-the-o6-alkylguanine-dna-alkyltransferase\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/exon-5-polymorphisms-in-the-o6-alkylguanine-dna-alkyltransferase\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/www.aprifel.com\/fr\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"R\u00e9sum\u00e9s\",\"item\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Exon 5 polymorphisms in the o6-alkylguanine dna alkyltransferase gene and lung cancer risk in non-smokers exposed to second-hand smoke.\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.aprifel.com\/fr\/#website\",\"url\":\"https:\/\/www.aprifel.com\/fr\/\",\"name\":\"Aprifel\",\"description\":\"Agence pour la Recherche et l\u2019Information en Fruits et L\u00e9gumes\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.aprifel.com\/fr\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Exon 5 polymorphisms in the o6-alkylguanine dna alkyltransferase gene and lung cancer risk in non-smokers exposed to second-hand smoke. - Aprifel","description":"Exon 5 polymorphisms in the o6-alkylguanine dna alkyltransferase gene and lung cancer risk in non-smokers exposed to second-hand smoke. - Aprifel","robots":{"index":"noindex","follow":"follow"},"og_locale":"fr_FR","og_type":"article","og_title":"Exon 5 polymorphisms in the o6-alkylguanine dna alkyltransferase gene and lung cancer risk in non-smokers exposed to second-hand smoke.","og_description":"Exon 5 polymorphisms in the o6-alkylguanine dna alkyltransferase gene and lung cancer risk in non-smokers exposed to second-hand smoke.","og_url":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/exon-5-polymorphisms-in-the-o6-alkylguanine-dna-alkyltransferase\/","og_site_name":"Aprifel","twitter_card":"summary_large_image","twitter_misc":{"Dur\u00e9e de lecture estim\u00e9e":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/exon-5-polymorphisms-in-the-o6-alkylguanine-dna-alkyltransferase\/","url":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/exon-5-polymorphisms-in-the-o6-alkylguanine-dna-alkyltransferase\/","name":"Exon 5 polymorphisms in the o6-alkylguanine dna alkyltransferase gene and lung cancer risk in non-smokers exposed to second-hand smoke. - Aprifel","isPartOf":{"@id":"https:\/\/www.aprifel.com\/fr\/#website"},"datePublished":"2018-12-04T05:04:06+00:00","dateModified":"2018-12-04T05:04:06+00:00","description":"Exon 5 polymorphisms in the o6-alkylguanine dna alkyltransferase gene and lung cancer risk in non-smokers exposed to second-hand smoke. - Aprifel","breadcrumb":{"@id":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/exon-5-polymorphisms-in-the-o6-alkylguanine-dna-alkyltransferase\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/exon-5-polymorphisms-in-the-o6-alkylguanine-dna-alkyltransferase\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/exon-5-polymorphisms-in-the-o6-alkylguanine-dna-alkyltransferase\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/www.aprifel.com\/fr\/"},{"@type":"ListItem","position":2,"name":"R\u00e9sum\u00e9s","item":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/"},{"@type":"ListItem","position":3,"name":"Exon 5 polymorphisms in the o6-alkylguanine dna alkyltransferase gene and lung cancer risk in non-smokers exposed to second-hand smoke."}]},{"@type":"WebSite","@id":"https:\/\/www.aprifel.com\/fr\/#website","url":"https:\/\/www.aprifel.com\/fr\/","name":"Aprifel","description":"Agence pour la Recherche et l\u2019Information en Fruits et L\u00e9gumes","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.aprifel.com\/fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"}]}},"_links":{"self":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/resume\/52520"}],"collection":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/resume"}],"about":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/types\/resume"}],"wp:attachment":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/media?parent=52520"}],"wp:term":[{"taxonomy":"mots_cles","embeddable":true,"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/mots_cles?post=52520"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}