{"id":52466,"date":"2004-02-01T00:00:00","date_gmt":"2018-12-04T05:03:13","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/low-plasma-lycopene-concentration-is-associated-with-increased\/"},"modified":"2018-12-04T06:03:13","modified_gmt":"2018-12-04T05:03:13","slug":"low-plasma-lycopene-concentration-is-associated-with-increased","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/low-plasma-lycopene-concentration-is-associated-with-increased\/","title":{"rendered":"Low plasma lycopene concentration is associated with increased mortality in a cohort of patients with prior oral, pharynx or larynx cancers"},"content":{"rendered":"<p>OBJECTIVE: This analysis was conducted to evaluate the association between plasma beta-carotene, alpha-carotene, lycopene, lutein\/zeaxanthin, total carotenoids, retinol, alpha-tocopherol and subsequent mortality. METHODS: Blood samples collected longitudinally from 259 participants in a chemoprevention trial aimed at the prevention of second cancers of the oral cavity, pharynx, or larynx were analyzed by high performance liquid chromatography for selected micronutrients. All-cause mortality (primary outcome) and cause-specific mortality (secondary outcomes) were evaluated in relation to plasma micronutrient concentrations at baseline and longitudinally. RESULTS: A total of 61 deaths occurred over a follow-up time of up to 90 months. Cox proportional hazards models with time-dependent covariates were used for data analyses. In models adjusted for age, plasma cholesterol, time-dependent smoking, treatment arm, study site and gender, only plasma lycopene was significantly inversely associated with total mortality [hazard ratio (HR) above versus below median = 0.53, 95% confidence interval (CI) 0.30-0.93]. Plasma alpha-carotene was inversely associated (HR 0.24, 95% CI 0.08-0.75) while plasma retinol was positively associated (HR 5.12, 95% CI 1.54-17.05) with cardiovascular death. Smoking status modified plasma nutrient associations with total mortality. Lycopene (HR 0.08, 95% CI 0.02-0.36), alpha-carotene (HR 0.25, 95% CI 0.09-0.73) and total carotenoids (HR 0.22, 95% CI 0.07-0.70) were inversely associated with mortality in non-smokers, while plasma retinol (HR = 3.56, 95% CI 1.40-9.09) and alpha-tocopherol (HR = 2.47, 95% CI 1.02-5.98) were positively associated with mortality in smokers. CONCLUSIONS: Only plasma lycopene was significantly associated (inversely) with total mortality in the full study population. Smoking modifies associations between nutrients and mortality.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-52466","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Dept. of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520-8034, USA. suan.mayne@yale.edu","annee":"2004","mois":"2","numero":"23:1","page":"34-42","auteurs":[{"ID":29070,"post_author":"0","post_date":"2018-12-03 23:14:07","post_date_gmt":"2018-12-03 22:14:07","post_content":"","post_title":"S T Mayne","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"s-t-mayne","to_ping":"","pinged":"","post_modified":"2018-12-03 23:14:07","post_modified_gmt":"2018-12-03 22:14:07","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/s-t-mayne\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":51435,"post_author":"0","post_date":"2018-12-04 05:37:41","post_date_gmt":"2018-12-04 04:37:41","post_content":"","post_title":"Lin","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"lin-6","to_ping":"","pinged":"","post_modified":"2018-12-04 05:37:41","post_modified_gmt":"2018-12-04 04:37:41","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/lin-6\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":40910,"post_author":"0","post_date":"2018-12-04 02:23:56","post_date_gmt":"2018-12-04 01:23:56","post_content":"","post_title":"Zheng","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"zheng-2","to_ping":"","pinged":"","post_modified":"2018-12-04 02:23:56","post_modified_gmt":"2018-12-04 01:23:56","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/zheng-2\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":32810,"post_author":"0","post_date":"2018-12-04 00:03:58","post_date_gmt":"2018-12-03 23:03:58","post_content":"","post_title":"Brenda Cartmel","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"brenda-cartmel","to_ping":"","pinged":"","post_modified":"2018-12-04 00:03:58","post_modified_gmt":"2018-12-03 23:03:58","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/brenda-cartmel\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":52465,"post_author":"0","post_date":"2018-12-04 06:03:12","post_date_gmt":"2018-12-04 05:03:12","post_content":"","post_title":"Goodwin","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"goodwin-3","to_ping":"","pinged":"","post_modified":"2018-12-04 06:03:12","post_modified_gmt":"2018-12-04 05:03:12","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/goodwin-3\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":46381,"post_author":"0","post_date":"2018-12-04 03:56:53","post_date_gmt":"2018-12-04 02:56:53","post_content":"","post_title":"JOURNAL OF AMERICAN COLLEGE OF NUTRITION","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"journal-of-american-college-of-nutrition","to_ping":"","pinged":"","post_modified":"2018-12-04 03:56:53","post_modified_gmt":"2018-12-04 02:56:53","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/journal-of-american-college-of-nutrition\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - 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