{"id":52403,"date":"2004-04-01T00:00:00","date_gmt":"2018-12-04T05:02:11","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/plasma-c-reactive-protein-concentrations-in-active-and-passive\/"},"modified":"2018-12-04T06:02:11","modified_gmt":"2018-12-04T05:02:11","slug":"plasma-c-reactive-protein-concentrations-in-active-and-passive","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/plasma-c-reactive-protein-concentrations-in-active-and-passive\/","title":{"rendered":"Plasma c-reactive protein concentrations in active and passive smokers: influence of antioxidant supplementation."},"content":{"rendered":"

OBJECTIVE: C-reactive protein (CRP) may directly affect the progression of atherosclerosis, and therefore, may be a target for reducing disease risk. The objective was to determine whether antioxidant supplementation reduces plasma CRP in active and passive smokers. DESIGN: Randomized, double-blind, placebo-controlled, parallel group trial with 2 months exposure to study supplements. SETTING: Berkeley and Oakland, California. SUBJECTS: Healthy adult men and women, consuming or =10.0 mg\/L). A total of 1393 individuals were screened, 216 randomized, 203 completed the study, and 160 were included in the analysis. INTERVENTIONS: Participants were randomized to receive a placebo or vitamin C (515 mg\/day) or antioxidant mixture (per day: 515 mg vitamin C, 371 mg alpha-tocopherol, 171 mg gamma-tocopherol, 252 mg mixed tocotrienols, and 95 mg alpha-lipoic acid). Measures of Outcome: Change in plasma CRP concentration. RESULTS: Vitamin C supplementation yielded a 24.0% reduction (95% confidence interval, -38.9% to -5.5%, p = 0.036 compared to control) in plasma CRP, whereas the antioxidant mixture and placebo produced a nonsignificant 4.7% reduction (-23.9% to 19.3%) and 4.3% increase (-15.1% to 28.2%), respectively. Results were adjusted for baseline body mass index and CRP concentrations. CONCLUSIONS: Plasma CRP itself may serve as a potential target for reducing the risk of atherosclerosis, and antioxidants, including vitamin C, should be investigated further to confirm their CRP-lowering and anti-inflammatory effects.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-52403","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Division of Community Health and Human Development, School of Public Health, University of California, Berkeley, California 94720, USA. Gblock@berkeley.edu","annee":"2004","mois":"4","numero":"23:2","page":"141-147","auteurs":[{"ID":12357,"post_author":"0","post_date":"2018-12-03 18:45:36","post_date_gmt":"2018-12-03 17:45:36","post_content":"","post_title":"Gladys Block","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"gladys-block","to_ping":"","pinged":"","post_modified":"2018-12-03 18:45:36","post_modified_gmt":"2018-12-03 17:45:36","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/gladys-block\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":52400,"post_author":"0","post_date":"2018-12-04 06:02:09","post_date_gmt":"2018-12-04 05:02:09","post_content":"","post_title":"Norkus","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"norkus","to_ping":"","pinged":"","post_modified":"2018-12-04 06:02:09","post_modified_gmt":"2018-12-04 05:02:09","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/norkus\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":52401,"post_author":"0","post_date":"2018-12-04 06:02:10","post_date_gmt":"2018-12-04 05:02:10","post_content":"","post_title":"Packer","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"packer","to_ping":"","pinged":"","post_modified":"2018-12-04 06:02:10","post_modified_gmt":"2018-12-04 05:02:10","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/packer\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":52402,"post_author":"0","post_date":"2018-12-04 06:02:10","post_date_gmt":"2018-12-04 05:02:10","post_content":"","post_title":"Dietrich","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"dietrich-4","to_ping":"","pinged":"","post_modified":"2018-12-04 06:02:10","post_modified_gmt":"2018-12-04 05:02:10","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/dietrich-4\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":23209,"post_author":"0","post_date":"2018-12-03 21:20:48","post_date_gmt":"2018-12-03 20:20:48","post_content":"","post_title":"Mark Hudes","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"mark-hudes","to_ping":"","pinged":"","post_modified":"2018-12-03 21:20:48","post_modified_gmt":"2018-12-03 20:20:48","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/mark-hudes\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":40403,"post_author":"0","post_date":"2018-12-04 02:13:51","post_date_gmt":"2018-12-04 01:13:51","post_content":"","post_title":"Jensen","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"jensen","to_ping":"","pinged":"","post_modified":"2018-12-04 02:13:51","post_modified_gmt":"2018-12-04 01:13:51","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/jensen\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":46381,"post_author":"0","post_date":"2018-12-04 03:56:53","post_date_gmt":"2018-12-04 02:56:53","post_content":"","post_title":"JOURNAL OF AMERICAN COLLEGE OF NUTRITION","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"journal-of-american-college-of-nutrition","to_ping":"","pinged":"","post_modified":"2018-12-04 03:56:53","post_modified_gmt":"2018-12-04 02:56:53","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/journal-of-american-college-of-nutrition\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"\nPlasma c-reactive protein concentrations in active and passive smokers: influence of antioxidant supplementation. - 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