{"id":52358,"date":"2004-04-01T00:00:00","date_gmt":"2018-12-04T05:01:27","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/dietary-alpha-linolenic-acid-is-associated-with-reduced-risk\/"},"modified":"2018-12-04T06:01:27","modified_gmt":"2018-12-04T05:01:27","slug":"dietary-alpha-linolenic-acid-is-associated-with-reduced-risk","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/dietary-alpha-linolenic-acid-is-associated-with-reduced-risk\/","title":{"rendered":"Dietary alpha-linolenic acid is associated with reduced risk of fatal coronary heart disease, but increased prostate cancer risk: a meta-analysis."},"content":{"rendered":"<p>The objective of this meta-analysis was to estimate quantitatively the associations between intake of alpha-linolenic acid [ALA, the (n-3) fatty acid in vegetable oils], mortality from heart disease, and the occurrence of prostate cancer in observational studies. We identified 5 prospective cohort studies that reported intake of ALA and mortality from heart disease. We also reviewed data from 3 clinical trials on ALA intake and heart disease. In addition, we identified 9 cohort and case-control studies that reported on the association between ALA intake or blood levels and incidence or prevalence of prostate cancer. We combined risk estimates across studies using a random-effects model. High ALA intake was associated with reduced risk of fatal heart disease in prospective cohort studies (combined relative risk 0.79, 95% CI 0.60-1.04). Three open-label trials also indicated that ALA may protect against heart disease. However, epidemiologic studies also showed an increased risk of prostate cancer in men with a high intake or blood level of ALA (combined relative risk 1.70; 95% CI 1.12-2.58). This meta-analysis shows that consumption of ALA might reduce heart disease mortality. However, the association between high intake of ALA and prostate cancer is of concern and warrants further study.<\/p>\n<p>Publication Types:<br \/>\nMeta-Analysis<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-52358","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Wageningen Centre for Food Sciences, Wageningen, the Netherlands. ingeborg.brouwer@wur.nl","annee":"2004","mois":"4","numero":"134:4","page":"919-922","auteurs":[{"ID":45728,"post_author":"0","post_date":"2018-12-04 03:45:41","post_date_gmt":"2018-12-04 02:45:41","post_content":"","post_title":"Katan","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"katan","to_ping":"","pinged":"","post_modified":"2018-12-04 03:45:41","post_modified_gmt":"2018-12-04 02:45:41","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/katan\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":52357,"post_author":"0","post_date":"2018-12-04 06:01:26","post_date_gmt":"2018-12-04 05:01:26","post_content":"","post_title":"Zock","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"zock","to_ping":"","pinged":"","post_modified":"2018-12-04 06:01:26","post_modified_gmt":"2018-12-04 05:01:26","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/zock\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":7967,"post_author":"0","post_date":"2018-12-03 17:54:49","post_date_gmt":"2018-12-03 16:54:49","post_content":"","post_title":"Ingeborg A Brouwer","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"ingeborg-a-brouwer","to_ping":"","pinged":"","post_modified":"2018-12-03 17:54:49","post_modified_gmt":"2018-12-03 16:54:49","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/ingeborg-a-brouwer\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":44294,"post_author":"0","post_date":"2018-12-04 03:21:12","post_date_gmt":"2018-12-04 02:21:12","post_content":"","post_title":"JOURNAL OF NUTRITION","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"journal-of-nutrition","to_ping":"","pinged":"","post_modified":"2018-12-04 03:21:12","post_modified_gmt":"2018-12-04 02:21:12","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/journal-of-nutrition\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - 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