{"id":51806,"date":"2004-11-01T00:00:00","date_gmt":"2018-12-04T04:44:42","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/carotenoids-vitamin-a-and-risk-of-adenomatous-polyp-recurrence\/"},"modified":"2018-12-04T05:44:42","modified_gmt":"2018-12-04T04:44:42","slug":"carotenoids-vitamin-a-and-risk-of-adenomatous-polyp-recurrence","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/carotenoids-vitamin-a-and-risk-of-adenomatous-polyp-recurrence\/","title":{"rendered":"Carotenoids, vitamin a and risk of adenomatous polyp recurrence in the polyp prevention trial."},"content":{"rendered":"

One trial reported beta-carotene supplementation was protective of adenomatous polyp recurrence in nonsmokers. We now examine the relation of serum and dietary carotenoids and vitamin A to adenomatous polyp recurrence in a subcohort of 834 participants in a low fat, high fiber, high fruit and vegetable dietary intervention, the Polyp Prevention Trial. Multivariate odds ratio (OR) and 95% confidence intervals (CI) of polyp recurrence were obtained using baseline or the average (first 3 years of the trial) carotenoid and vitamin A values after adjustment for covariates. Compared to the lowest quartile of baseline alpha-carotene concentrations, the OR of multiple polyp recurrence for the highest quartile was 0.55 (95% CI = 0.30-0.99) and the OR of right-sided recurrence was 0.60 (95% CI = 0.37-0.95). Baseline dietary intakes of alpha-carotene and vitamin A from food with\/without supplements were inversely associated with any recurrence (p for linear trend = 0.03-alpha-carotene; p = 0.004 and p = 0.007 -intakes of vitamin A). Compared to the lowest quartile of averaged beta-carotene concentrations, the OR of multiple adenomas for the highest quartile was 0.40 (95% CI = 0.22-0.75) with an inverse trend (p = 0.02). The risk was inversely related to averaged: alpha-carotene concentrations and right-sided polyps; alpha-carotene intake and recurrence of any, multiple and right-sided polyps; beta-carotene intake and multiple adenoma recurrence; vitamin A from food (with supplements) and each adverse endpoint. Thus, alpha-carotene and vitamin A may protect against recurrence in nonsmokers and nondrinkers or be indicative of compliance or another healthy lifestyle factor that reduces risk.<\/p>\n

Publication Types:
\nClinical Trial
\nMulticenter Study
\nRandomized Controlled Trial <\/p>\n","protected":false},"template":"","mots_cles":[225],"class_list":["post-51806","resume","type-resume","status-publish","hentry","mots_cles-prevention"],"acf":{"auteurs":null,"adresse":null,"numero":null,"page":null,"mois":null,"annee":null,"mots-cles":null,"sources":null},"yoast_head":"\nCarotenoids, vitamin a and risk of adenomatous polyp recurrence in the polyp prevention trial. - Aprifel<\/title>\n<meta name=\"description\" content=\"Carotenoids, vitamin a and risk of adenomatous polyp recurrence in the polyp prevention trial. - Aprifel\" \/>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Carotenoids, vitamin a and risk of adenomatous polyp recurrence in the polyp prevention trial.\" \/>\n<meta property=\"og:description\" content=\"Carotenoids, vitamin a and risk of adenomatous polyp recurrence in the polyp prevention trial.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/carotenoids-vitamin-a-and-risk-of-adenomatous-polyp-recurrence\/\" \/>\n<meta property=\"og:site_name\" content=\"Aprifel\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/carotenoids-vitamin-a-and-risk-of-adenomatous-polyp-recurrence\/\",\"url\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/carotenoids-vitamin-a-and-risk-of-adenomatous-polyp-recurrence\/\",\"name\":\"Carotenoids, vitamin a and risk of adenomatous polyp recurrence in the polyp prevention trial. - 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