{"id":51141,"date":"2005-01-01T00:00:00","date_gmt":"2018-12-04T04:32:54","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/mise-au-point-manifestations-rhumatologiques-du-scorbut\/"},"modified":"2018-12-04T05:32:54","modified_gmt":"2018-12-04T04:32:54","slug":"mise-au-point-manifestations-rhumatologiques-du-scorbut","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/mise-au-point-manifestations-rhumatologiques-du-scorbut\/","title":{"rendered":"Mise au point \r\nmanifestations rhumatologiques du scorbut"},"content":{"rendered":"

Abstract
\nLe scorbut atteint pr\u00e9f\u00e9rentiellement mais pas uniquement les sujets \u00e2g\u00e9s et les exclus, par consommation insuffisante de fruits et l\u00e9gumes frais. Les manifestations cliniques sont une asth\u00e9nie, un purpura vasculaire, un syndrome h\u00e9morragique, une atteinte stomatologique. Les manifestations articulaires sont pr\u00e9sentes dans 80 % des cas : arthralgies, myalgies, h\u00e9marthroses associ\u00e9es \u00e0 des h\u00e9matomes intramusculaires. La d\u00e9pl\u00e9tion vitaminique entra\u00eene une alt\u00e9ration de la structure du collag\u00e8ne, un d\u00e9faut de formation de la matrice ost\u00e9o\u00efde et une augmentation de la r\u00e9sorption osseuse. Les signes radiologiques sont vari\u00e9s : ost\u00e9olyse avec parfois pincement articulaire, ost\u00e9on\u00e9crose, ost\u00e9op\u00e9nie, prolif\u00e9ration p\u00e9riost\u00e9e. L’ost\u00e9oporose trab\u00e9culaire et corticale est fr\u00e9quente. Chez l’enfant, le scorbut est responsable de douleurs intenses des membres inf\u00e9rieurs li\u00e9es \u00e0 des h\u00e9morragies sous-p\u00e9riost\u00e9es. Les signes biologiques sont non sp\u00e9cifiques : an\u00e9mie, hypocholest\u00e9rol\u00e9mie, hypoalbumin\u00e9mie. Le diagnostic est confirm\u00e9 par le dosage d’ascorb\u00e9mie (inf\u00e9rieur \u00e0 2,5 mg\/l). L’administration de vitamine C corrige rapidement les sympt\u00f4mes.<\/p>\n

Scurvy occurs in individuals who eat inadequate amounts of fresh fruit or vegetables, often because of dietary imbalances related to advanced age or homelessness. Asthenia, vascular purpura, bleeding, and gum abnormalities are the main symptoms. In 80% of cases, the manifestations of scurvy include musculoskeletal symptoms consisting of arthralgia, myalgia, hemarthrosis, and muscular hematomas. Vitamin C depletion is responsible for structural collagen alterations, defective osteoid matrix formation, and increased bone resorption. Imaging studies may show osteolysis, joint space loss, osteonecrosis, osteopenia, and\/or periosteal proliferation. Trabecular and cortical osteoporosis is common. Children experience severe lower limb pain related to subperiosteal bleeding. Laboratory tests show nonspecific abnormalities including anemia and low levels of cholesterol and albumin. The finding of a serum ascorbic acid level lower than 2.5 mg\/l confirms the diagnosis. Vitamin C supplementation ensures prompt resolution of the symptoms. <\/p>\n

Mots-cl\u00e9: Scorbut; Vitamine C; Carence vitaminique; H\u00e9marthrose; Ost\u00e9oporose; Maladie de Barlow <\/p>\n

Pour citer cet article, utiliser ce titre en anglais et sa r\u00e9f\u00e9rence dans le m\u00eame volume de Joint Bone Spine. <\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-51141","resume","type-resume","status-publish","hentry"],"acf":{"auteurs":null,"adresse":null,"numero":null,"page":null,"mois":null,"annee":null,"mots-cles":null,"sources":null},"yoast_head":"\nMise au point manifestations rhumatologiques du scorbut - Aprifel<\/title>\n<meta name=\"description\" content=\"Mise au point manifestations rhumatologiques du scorbut - Aprifel\" \/>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mise au point manifestations rhumatologiques du scorbut\" \/>\n<meta property=\"og:description\" content=\"Mise au point manifestations rhumatologiques du scorbut\" \/>\n<meta property=\"og:url\" content=\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/mise-au-point-manifestations-rhumatologiques-du-scorbut\/\" \/>\n<meta property=\"og:site_name\" content=\"Aprifel\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/mise-au-point-manifestations-rhumatologiques-du-scorbut\/\",\"url\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/mise-au-point-manifestations-rhumatologiques-du-scorbut\/\",\"name\":\"Mise au point manifestations rhumatologiques du scorbut - 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