{"id":50885,"date":"2005-05-01T00:00:00","date_gmt":"2018-12-04T04:27:13","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/microsatellite-polymorphisms-in-the-epidermal-growth-factor\/"},"modified":"2018-12-04T05:27:13","modified_gmt":"2018-12-04T04:27:13","slug":"microsatellite-polymorphisms-in-the-epidermal-growth-factor","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/microsatellite-polymorphisms-in-the-epidermal-growth-factor\/","title":{"rendered":"Microsatellite polymorphisms in the epidermal growth factor receptor (egfr) gene and the transforming growth factor-alpha (tgfa) gene and risk of oral cancer in puerto rico."},"content":{"rendered":"

OBJECTIVES AND METHODS: Risks of oral cancer related to a CA microsatellite repeat polymorphism in intron 1 of the epidermal growth factor receptor (EGFR) gene and a TaqI polymorphism in the transforming growth factor-alpha (TGFA) gene were evaluated in a population-based case-control study consisting of 157 cases and 149 controls recruited in Puerto Rico. RESULTS: Carriers of >\/=16 CA repeats in EGFR showed a 1.9-fold increased risk for oral cancer (OR=1.9, 95% CI=1.0-3.5). Risks also tended to increase with decreasing number of alleles with >\/=16 CA repeats (P for trend=0.06). Our data suggested a non-significant reduction in risk for subjects heterozygous for the TGFA polymorphism (OR=0.6, 95% CI=0.2-1.3). CONCLUSIONS: The EGFR-associated risk appeared to be independent of tobacco and alcohol use and may be restricted primarily to subjects who consumed low amounts of fresh fruits and vegetables (OR=5.9, 95%CI: 2.3-15.2). These data implicate dietary and molecular targets for oral cancer prevention.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-50885","resume","type-resume","status-publish","hentry"],"acf":{"auteurs":null,"adresse":null,"numero":null,"page":null,"mois":null,"annee":null,"mots-cles":null,"sources":null},"yoast_head":"\nMicrosatellite polymorphisms in the epidermal growth factor receptor (egfr) gene and the transforming growth factor-alpha (tgfa) gene and risk of oral cancer in puerto rico. - Aprifel<\/title>\n<meta name=\"description\" content=\"Microsatellite polymorphisms in the epidermal growth factor receptor (egfr) gene and the transforming growth factor-alpha (tgfa) gene and risk of oral cancer in puerto rico. - Aprifel\" \/>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Microsatellite polymorphisms in the epidermal growth factor receptor (egfr) gene and the transforming growth factor-alpha (tgfa) gene and risk of oral cancer in puerto rico.\" \/>\n<meta property=\"og:description\" content=\"Microsatellite polymorphisms in the epidermal growth factor receptor (egfr) gene and the transforming growth factor-alpha (tgfa) gene and risk of oral cancer in puerto rico.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/microsatellite-polymorphisms-in-the-epidermal-growth-factor\/\" \/>\n<meta property=\"og:site_name\" content=\"Aprifel\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/microsatellite-polymorphisms-in-the-epidermal-growth-factor\/\",\"url\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/microsatellite-polymorphisms-in-the-epidermal-growth-factor\/\",\"name\":\"Microsatellite polymorphisms in the epidermal growth factor receptor (egfr) gene and the transforming growth factor-alpha (tgfa) gene and risk of oral cancer in puerto rico. - 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