{"id":50378,"date":"2005-07-01T00:00:00","date_gmt":"2018-12-04T04:15:40","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/relationship-between-testosterone-levels-insulin-sensitivity\/"},"modified":"2018-12-04T05:15:40","modified_gmt":"2018-12-04T04:15:40","slug":"relationship-between-testosterone-levels-insulin-sensitivity","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/relationship-between-testosterone-levels-insulin-sensitivity\/","title":{"rendered":"Relationship between testosterone levels, insulin sensitivity, and mitochondrial function in men."},"content":{"rendered":"<p>OBJECTIVE: The goal of this study was to examine the relationship between serum testosterone levels and insulin sensitivity and mitochondrial function in men. RESEARCH DESIGN AND METHODS: A total of 60 men (mean age 60.5 +\/- 1.2 years) had a detailed hormonal and metabolic evaluation. Insulin sensitivity was measured using a hyperinsulinemic-euglycemic clamp. Mitochondrial function was assessed by measuring maximal aerobic capacity (V(O2max)) and expression of oxidative phosphorylation genes in skeletal muscle. RESULTS: A total of 45% of subjects had normal glucose tolerance, 20% had impaired glucose tolerance, and 35% had type 2 diabetes. Testosterone levels were positively correlated with insulin sensitivity (r = 0.4, P 25 kg\/m(2) and a threefold higher prevalence of the metabolic syndrome than their eugonadal counterparts (n = 50); this relationship held true after adjusting for age and sex hormone-binding globulin but not BMI. Testosterone levels also correlated with V(O2max) (r = 0.43, P &lt; 0.05) and oxidative phosphorylation gene expression (r = 0.57, P &lt; 0.0001). CONCLUSIONS: These data indicate that low serum testosterone levels are associated with an adverse metabolic profile and suggest a novel unifying mechanism for the previously independent observations that low testosterone levels and impaired mitochondrial function promote insulin resistance in men.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-50378","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA.","annee":"2005","mois":"7","numero":"1636-1642","page":"28:7","auteurs":[{"ID":48876,"post_author":"0","post_date":"2018-12-04 04:46:48","post_date_gmt":"2018-12-04 03:46:48","post_content":"","post_title":"Lee","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"lee-18","to_ping":"","pinged":"","post_modified":"2018-12-04 04:46:48","post_modified_gmt":"2018-12-04 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