{"id":50066,"date":"2005-07-01T00:00:00","date_gmt":"2018-12-04T04:10:20","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/direct-comparison-of-dietary-portfolio-vs-statin-on-c-reactive\/"},"modified":"2018-12-04T05:10:20","modified_gmt":"2018-12-04T04:10:20","slug":"direct-comparison-of-dietary-portfolio-vs-statin-on-c-reactive","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/direct-comparison-of-dietary-portfolio-vs-statin-on-c-reactive\/","title":{"rendered":"Direct comparison of dietary portfolio vs statin on c-reactive protein."},"content":{"rendered":"<p>BACKGROUND: 3-Hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) markedly reduce serum cholesterol and have anti-inflammatory effects. The effect of cholesterol-lowering diets on inflammatory biomarkers is less well known. OBJECTIVE: To compare the efficacy of a dietary combination (portfolio) of cholesterol-lowering foods vs a statin in reducing C-reactive protein (CRP) as a biomarker of inflammation linked to increased cardiovascular disease risk. METHODS: In all, 34 hyperlipidemic subjects completed three 1-month treatments as outpatients in random order: a very low-saturated fat diet (control); the same diet with 20 mg lovastatin (statin); and a diet high in plant sterols (1.0 g\/1000 kcal), soy protein (21.4 g\/1000 kcal), viscous fibers (9.8 g\/1000 kcal), and almonds (14 g\/1000 kcal) (portfolio). Fasting blood samples were obtained at weeks 0, 2, and 4. RESULTS: Using the complete data, no treatment reduced serum CRP. However, when subjects with CRP levels above the 75th percentile for previously reported studies (&gt; 3.5 mg\/l) were excluded, CRP was reduced similarly on both statin, -16.3 +\/- 6.7% (n = 23, P = 0.013) and dietary portfolio, -23.8 +\/- 6.9% (n = 25, P = 0.001) but not the control, 15.3 +\/- 13.6% (n = 28, P = 0.907). The percentage CRP change from baseline on the portfolio treatment (n = 25) was greater than the control (n = 28, P = 0.004) but similar to statin treatment (n = 23, P = 0.349). Both statin and portfolio treatments were similar in reducing CRP and numerically more effective than control but only the change in portfolio was significant after the Bonferroni adjustment. CONCLUSIONS: A combination of cholesterol-lowering foods reduced C-reactive protein to a similar extent as the starting dose of a first-generation statin.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-50066","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Clinical Nutrition and Risk Factor Modification Center, St Michael's Hospital, Toronto, Ontario, Canada.","annee":"2005","mois":"7","numero":"59:7","page":"851-860","auteurs":[{"ID":44228,"post_author":"0","post_date":"2018-12-04 03:19:52","post_date_gmt":"2018-12-04 02:19:52","post_content":"","post_title":"Jenkins","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"jenkins","to_ping":"","pinged":"","post_modified":"2018-12-04 03:19:52","post_modified_gmt":"2018-12-04 02:19:52","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/jenkins\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":15393,"post_author":"0","post_date":"2018-12-03 19:25:06","post_date_gmt":"2018-12-03 18:25:06","post_content":"","post_title":"Cyril W C Kendall","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"cyril-w-c-kendall","to_ping":"","pinged":"","post_modified":"2018-12-03 19:25:06","post_modified_gmt":"2018-12-03 18:25:06","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/cyril-w-c-kendall\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":50060,"post_author":"0","post_date":"2018-12-04 05:10:15","post_date_gmt":"2018-12-04 04:10:15","post_content":"","post_title":"Connelly","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"connelly-2","to_ping":"","pinged":"","post_modified":"2018-12-04 05:10:15","post_modified_gmt":"2018-12-04 04:10:15","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/connelly-2\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":23295,"post_author":"0","post_date":"2018-12-03 21:22:53","post_date_gmt":"2018-12-03 20:22:53","post_content":"","post_title":"L A Leiter","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"l-a-leiter","to_ping":"","pinged":"","post_modified":"2018-12-03 21:22:53","post_modified_gmt":"2018-12-03 20:22:53","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/l-a-leiter\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":50061,"post_author":"0","post_date":"2018-12-04 05:10:16","post_date_gmt":"2018-12-04 04:10:16","post_content":"","post_title":"Josse","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"josse","to_ping":"","pinged":"","post_modified":"2018-12-04 05:10:16","post_modified_gmt":"2018-12-04 04:10:16","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/josse\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":50062,"post_author":"0","post_date":"2018-12-04 05:10:17","post_date_gmt":"2018-12-04 04:10:17","post_content":"","post_title":"Marchie","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"marchie","to_ping":"","pinged":"","post_modified":"2018-12-04 05:10:17","post_modified_gmt":"2018-12-04 04:10:17","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/marchie\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":50063,"post_author":"0","post_date":"2018-12-04 05:10:17","post_date_gmt":"2018-12-04 04:10:17","post_content":"","post_title":"Parker","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"parker-5","to_ping":"","pinged":"","post_modified":"2018-12-04 05:10:17","post_modified_gmt":"2018-12-04 04:10:17","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/parker-5\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":30695,"post_author":"0","post_date":"2018-12-03 23:35:15","post_date_gmt":"2018-12-03 22:35:15","post_content":"","post_title":"William Singer","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"william-singer","to_ping":"","pinged":"","post_modified":"2018-12-03 23:35:15","post_modified_gmt":"2018-12-03 22:35:15","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/william-singer\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":30691,"post_author":"0","post_date":"2018-12-03 23:35:12","post_date_gmt":"2018-12-03 22:35:12","post_content":"","post_title":"Dorothea A Faulkner","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"dorothea-a-faulkner","to_ping":"","pinged":"","post_modified":"2018-12-03 23:35:12","post_modified_gmt":"2018-12-03 22:35:12","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/dorothea-a-faulkner\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":30687,"post_author":"0","post_date":"2018-12-03 23:35:10","post_date_gmt":"2018-12-03 22:35:10","post_content":"","post_title":"Julia M W Wong","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"julia-m-w-wong","to_ping":"","pinged":"","post_modified":"2018-12-03 23:35:10","post_modified_gmt":"2018-12-03 22:35:10","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/julia-m-w-wong\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":29789,"post_author":"0","post_date":"2018-12-03 23:23:42","post_date_gmt":"2018-12-03 22:23:42","post_content":"","post_title":"Rita Adriana de Souza","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"rita-adriana-de-souza","to_ping":"","pinged":"","post_modified":"2018-12-03 23:23:42","post_modified_gmt":"2018-12-03 22:23:42","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/rita-adriana-de-souza\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":50064,"post_author":"0","post_date":"2018-12-04 05:10:19","post_date_gmt":"2018-12-04 04:10:19","post_content":"","post_title":"Emam","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"emam","to_ping":"","pinged":"","post_modified":"2018-12-04 05:10:19","post_modified_gmt":"2018-12-04 04:10:19","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/emam\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":50065,"post_author":"0","post_date":"2018-12-04 05:10:19","post_date_gmt":"2018-12-04 04:10:19","post_content":"","post_title":"Josse","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"josse-2","to_ping":"","pinged":"","post_modified":"2018-12-04 05:10:19","post_modified_gmt":"2018-12-04 04:10:19","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/josse-2\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":1736,"post_author":"0","post_date":"2018-12-03 16:02:05","post_date_gmt":"2018-12-03 15:02:05","post_content":"","post_title":"Tanya J Little","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"tanya-j-little","to_ping":"","pinged":"","post_modified":"2018-12-03 16:02:05","post_modified_gmt":"2018-12-03 15:02:05","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/tanya-j-little\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":1262,"post_author":"0","post_date":"2018-12-03 15:57:47","post_date_gmt":"2018-12-03 14:57:47","post_content":"","post_title":"European journal of clinical nutrition","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"european-journal-of-clinical-nutrition","to_ping":"","pinged":"","post_modified":"2018-12-03 15:57:47","post_modified_gmt":"2018-12-03 14:57:47","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/european-journal-of-clinical-nutrition\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Direct comparison of dietary portfolio vs statin on c-reactive protein. - Aprifel<\/title>\n<meta name=\"description\" content=\"Direct comparison of dietary portfolio vs statin on c-reactive protein. - Aprifel\" \/>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Direct comparison of dietary portfolio vs statin on c-reactive protein.\" \/>\n<meta property=\"og:description\" content=\"Direct comparison of dietary portfolio vs statin on c-reactive protein.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/direct-comparison-of-dietary-portfolio-vs-statin-on-c-reactive\/\" \/>\n<meta property=\"og:site_name\" content=\"Aprifel\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/direct-comparison-of-dietary-portfolio-vs-statin-on-c-reactive\/\",\"url\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/direct-comparison-of-dietary-portfolio-vs-statin-on-c-reactive\/\",\"name\":\"Direct comparison of dietary portfolio vs statin on c-reactive protein. - Aprifel\",\"isPartOf\":{\"@id\":\"https:\/\/www.aprifel.com\/fr\/#website\"},\"datePublished\":\"2018-12-04T04:10:20+00:00\",\"dateModified\":\"2018-12-04T04:10:20+00:00\",\"description\":\"Direct comparison of dietary portfolio vs statin on c-reactive protein. - Aprifel\",\"breadcrumb\":{\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/direct-comparison-of-dietary-portfolio-vs-statin-on-c-reactive\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/direct-comparison-of-dietary-portfolio-vs-statin-on-c-reactive\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/direct-comparison-of-dietary-portfolio-vs-statin-on-c-reactive\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/www.aprifel.com\/fr\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"R\u00e9sum\u00e9s\",\"item\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Direct comparison of dietary portfolio vs statin on c-reactive protein.\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.aprifel.com\/fr\/#website\",\"url\":\"https:\/\/www.aprifel.com\/fr\/\",\"name\":\"Aprifel\",\"description\":\"Agence pour la Recherche et l\u2019Information en Fruits et L\u00e9gumes\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.aprifel.com\/fr\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Direct comparison of dietary portfolio vs statin on c-reactive protein. - Aprifel","description":"Direct comparison of dietary portfolio vs statin on c-reactive protein. - Aprifel","robots":{"index":"noindex","follow":"follow"},"og_locale":"fr_FR","og_type":"article","og_title":"Direct comparison of dietary portfolio vs statin on c-reactive protein.","og_description":"Direct comparison of dietary portfolio vs statin on c-reactive protein.","og_url":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/direct-comparison-of-dietary-portfolio-vs-statin-on-c-reactive\/","og_site_name":"Aprifel","twitter_card":"summary_large_image","twitter_misc":{"Dur\u00e9e de lecture estim\u00e9e":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/direct-comparison-of-dietary-portfolio-vs-statin-on-c-reactive\/","url":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/direct-comparison-of-dietary-portfolio-vs-statin-on-c-reactive\/","name":"Direct comparison of dietary portfolio vs statin on c-reactive protein. - Aprifel","isPartOf":{"@id":"https:\/\/www.aprifel.com\/fr\/#website"},"datePublished":"2018-12-04T04:10:20+00:00","dateModified":"2018-12-04T04:10:20+00:00","description":"Direct comparison of dietary portfolio vs statin on c-reactive protein. - Aprifel","breadcrumb":{"@id":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/direct-comparison-of-dietary-portfolio-vs-statin-on-c-reactive\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/direct-comparison-of-dietary-portfolio-vs-statin-on-c-reactive\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/direct-comparison-of-dietary-portfolio-vs-statin-on-c-reactive\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/www.aprifel.com\/fr\/"},{"@type":"ListItem","position":2,"name":"R\u00e9sum\u00e9s","item":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/"},{"@type":"ListItem","position":3,"name":"Direct comparison of dietary portfolio vs statin on c-reactive protein."}]},{"@type":"WebSite","@id":"https:\/\/www.aprifel.com\/fr\/#website","url":"https:\/\/www.aprifel.com\/fr\/","name":"Aprifel","description":"Agence pour la Recherche et l\u2019Information en Fruits et L\u00e9gumes","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.aprifel.com\/fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"}]}},"_links":{"self":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/resume\/50066"}],"collection":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/resume"}],"about":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/types\/resume"}],"wp:attachment":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/media?parent=50066"}],"wp:term":[{"taxonomy":"mots_cles","embeddable":true,"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/mots_cles?post=50066"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}