{"id":49679,"date":"2005-11-01T00:00:00","date_gmt":"2018-12-04T04:01:02","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/raw-vegetable-food-containing-high-cyclo-his-pro-improved\/"},"modified":"2018-12-04T05:01:02","modified_gmt":"2018-12-04T04:01:02","slug":"raw-vegetable-food-containing-high-cyclo-his-pro-improved","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/raw-vegetable-food-containing-high-cyclo-his-pro-improved\/","title":{"rendered":"Raw vegetable food containing high cyclo (his-pro) improved insulin sensitivity and body weight control."},"content":{"rendered":"<p>Cyclo (his-pro), controlled-energy diet, soy protein hydrolysate (SPH), and raw vegetable food (RVF) are known to improve insulin sensitivity and body weight (BW) control. Enhancement of high cyclo (his-pro) content in SPH (HCS) was performed by refluxing SPH with 1 N KH(2)CO(3) dissolved in 70% ethanol for 2 weeks at room temperature. Using this material, we examined the effects of HCS plus RVF on glucose metabolism and BW control in genetically diabetic Goto-Kakizaki (G-K) and insulin-resistant aged overweight Sprague-Dawley (S-D) rats. Thirty 7-week-old G-K rats and 18 16- to 18-month-old S-D rats were divided into 3 groups and treated with normal chow (NC), RVF diet, or HCS diet for 8 weeks. Raw vegetable food diet was made of 1:3 RVF and 2:3 NC; HCS diet was made of 1:27 portion HCS, 8:27 RVF, and 2:3 NC. Oral glucose tolerance significantly improved in both RVF- (P&lt;.01) and HCS-treated (P&lt;.001) G-K rats and worsened in NC-fed rats compared with the baseline values. Similarly, oral glucose tolerance also improved in aged overweight S-D rats when treated with RVF (P&lt;.05) and with HCS (P&lt;.01), compared with the baseline values. Although HCS diet treatment very significantly lowered fed plasma insulin levels compared with NC diet treatment in G-K rats (P&lt;.01), RVF diet treatment alone did not decrease plasma insulin levels. In contrast, there was no change of insulin levels in overweight aged S-D rats after either RVF or HCS diet treatment. Postfeeding glucose levels in G-K rats fed RVF or HCS significantly fell, compared with the rats fed NC (P&lt;.05). Interestingly, fasting blood glucose levels in RVF- or HCS-fed rats were very significantly lower than in NC-fed rats (P&lt;.001). There was no change of blood glucose levels in S-D rats due to treatments with different diet. In G-K rats, food intake did not decrease during the first 3 weeks but fell very significantly from the fifth to eighth weeks with RVF (P&lt;.01) and HCS (P&lt;.001) treatments in G-K rats. However, food intake reduction in aged S-D rats was shown only for the HCS-treated rat group (P&lt;.05). Water intake slightly decreased in G-K rats with either RVF or HCS treatment (P&lt;.05) but very significantly decreased in S-D rats with HCS treatment (P&lt;.01). Body weight gain in young G-K rats and BW in aged S-D rats significantly decreased only when rats were treated with HCS diet (P&lt;.05). These data suggest that regular consumption of HCS diet helps to control blood glucose metabolism in diabetic G-K rats and BW control in aged obese S-D rats.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-49679","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. moon.song2@med.va.gov.\r\n","annee":"2005","mois":"11","numero":"54:11","page":"1480-1489","auteurs":[{"ID":1702,"post_author":"0","post_date":"2018-12-03 16:01:47","post_date_gmt":"2018-12-03 15:01:47","post_content":"","post_title":"Haiping Yang","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"haiping-yang","to_ping":"","pinged":"","post_modified":"2018-12-03 16:01:47","post_modified_gmt":"2018-12-03 15:01:47","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/haiping-yang\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":49675,"post_author":"0","post_date":"2018-12-04 05:01:00","post_date_gmt":"2018-12-04 04:01:00","post_content":"","post_title":"Song","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"song-3","to_ping":"","pinged":"","post_modified":"2018-12-04 05:01:00","post_modified_gmt":"2018-12-04 04:01:00","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/song-3\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":49676,"post_author":"0","post_date":"2018-12-04 05:01:01","post_date_gmt":"2018-12-04 04:01:01","post_content":"","post_title":"Rosenthal","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"rosenthal-2","to_ping":"","pinged":"","post_modified":"2018-12-04 05:01:01","post_modified_gmt":"2018-12-04 04:01:01","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/rosenthal-2\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":49677,"post_author":"0","post_date":"2018-12-04 05:01:01","post_date_gmt":"2018-12-04 04:01:01","post_content":"","post_title":"Song","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"song-4","to_ping":"","pinged":"","post_modified":"2018-12-04 05:01:01","post_modified_gmt":"2018-12-04 04:01:01","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/song-4\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":48911,"post_author":"0","post_date":"2018-12-04 04:47:48","post_date_gmt":"2018-12-04 03:47:48","post_content":"","post_title":"Zhaojia","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"zhaojia","to_ping":"","pinged":"","post_modified":"2018-12-04 04:47:48","post_modified_gmt":"2018-12-04 03:47:48","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/zhaojia\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":49678,"post_author":"0","post_date":"2018-12-04 05:01:02","post_date_gmt":"2018-12-04 04:01:02","post_content":"","post_title":"Yamaguchi","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"yamaguchi","to_ping":"","pinged":"","post_modified":"2018-12-04 05:01:02","post_modified_gmt":"2018-12-04 04:01:02","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/yamaguchi\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":36392,"post_author":"0","post_date":"2018-12-04 00:59:12","post_date_gmt":"2018-12-03 23:59:12","post_content":"","post_title":"METABOLISM","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"metabolism","to_ping":"","pinged":"","post_modified":"2018-12-04 00:59:12","post_modified_gmt":"2018-12-03 23:59:12","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/metabolism\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - 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