{"id":48923,"date":"2006-01-01T00:00:00","date_gmt":"2018-12-04T03:48:08","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/a-prospective-study-of-lycopene-and-tomato-product-intake-and\/"},"modified":"2018-12-04T04:48:08","modified_gmt":"2018-12-04T03:48:08","slug":"a-prospective-study-of-lycopene-and-tomato-product-intake-and","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/a-prospective-study-of-lycopene-and-tomato-product-intake-and\/","title":{"rendered":"A prospective study of lycopene and tomato product intake and risk of prostate cancer"},"content":{"rendered":"<p style=\"text-align: justify\"><strong>Background: <\/strong><br \/>\nDietary lycopene and tomato products may reduce risk of prostate cancer; however, uncertainty remains about this possible association.<\/p>\n<p style=\"text-align: justify\"><strong>Methods: <\/strong><br \/>\nWe evaluated the association between intake of lycopene and specific tomato products and prostate cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, a multicenter study designed to investigate cancer early detection methods and etiologic determinants. Participants completed both a general risk factor and a 137-item food frequency questionnaire at baseline. A total of 1,338 cases of prostate cancer were identified among 29,361 men during an average of 4.2 years of follow-up.<\/p>\n<p style=\"text-align: justify\"><strong>Results: <\/strong><br \/>\nLycopene intake was not associated with prostate cancer risk. Reduced risks were also not found for total tomato servings or for most tomato-based foods. Statistically nonsignificant inverse associations were noted for pizza [all prostate cancer: relative risk (RR), 0.83; 95% confidence interval (95% CI), 0.67-1.03 for &gt;= 1 serving\/wk versus &lt; 0.5 serving\/mo; P-trend = 0.06 and advanced prostate cancer: RR, 0.79; 95% CI, 0.56-1.10; P-trend = 0.12] and spaghetti\/tomato sauce consumption (advanced prostate cancer: RR = 0.81, 95% Cl, 0.57-1.16 for &gt;= 2 servings\/wk versus &lt; 1 serving\/mo; P-trend = 0.31). Among men with a family history of prostate cancer, risks were decreased in relation to increased consumption of lycopene (P-trend = 0.04) and specific tomato-based foods commonly eaten with fat (spaghetti, P-trend = 0.12; pizza, P-trend = 0.15; lasagna, P-trend = 0.02).<\/p>\n<p style=\"text-align: justify\"><strong>Conclusions: <\/strong><br \/>\nThis large study does not support the hypothesis that greater lycopene\/tomato product consumption protects from prostate cancer. Evidence for protective associations in subjects with a family history of prostate cancer requires further corroboration.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-48923","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Addresses: Hayes RB (reprint author), NCI, Div Canc Epidemiol & Genet, Intramural Res Program, NIH,Dept Hlth & Human Serv, EPN 8114, Bethesda, MD 20892 USA\r\nNCI, Div Canc Epidemiol & Genet, Intramural Res Program, NIH,Dept Hlth & Human Serv, Bethesda, MD 20892 USA\r\nYale Univ, Sch Med, Dept Epidemiol & Publ Hlth, New Haven, CT 06510 USA\r\nNYU, Dept Nutr Food Studies & Publ Hlth, New York, NY USA\r\nUniv Alabama, Dept Surg, Div Urol, Birmingham, AL 35294 USA\r\nUniv Colorado, Div Urol Oncol, Aurora, CO USA \r\nE-mail Addresses: hayesr@mail.nih.gov","annee":"2006","mois":"0","numero":"15:1","page":"92-98","auteurs":[{"ID":29070,"post_author":"0","post_date":"2018-12-03 23:14:07","post_date_gmt":"2018-12-03 22:14:07","post_content":"","post_title":"S T Mayne","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"s-t-mayne","to_ping":"","pinged":"","post_modified":"2018-12-03 23:14:07","post_modified_gmt":"2018-12-03 22:14:07","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/s-t-mayne\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":19817,"post_author":"0","post_date":"2018-12-03 20:26:31","post_date_gmt":"2018-12-03 19:26:31","post_content":"","post_title":"L Beth Dixon","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"l-beth-dixon","to_ping":"","pinged":"","post_modified":"2018-12-03 20:26:31","post_modified_gmt":"2018-12-03 19:26:31","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/l-beth-dixon\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":25260,"post_author":"0","post_date":"2018-12-03 22:15:24","post_date_gmt":"2018-12-03 21:15:24","post_content":"","post_title":"Richard B Hayes","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"richard-b-hayes","to_ping":"","pinged":"","post_modified":"2018-12-03 22:15:24","post_modified_gmt":"2018-12-03 21:15:24","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/richard-b-hayes\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":48919,"post_author":"0","post_date":"2018-12-04 04:48:02","post_date_gmt":"2018-12-04 03:48:02","post_content":"","post_title":"Chatterjee","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"chatterjee-3","to_ping":"","pinged":"","post_modified":"2018-12-04 04:48:02","post_modified_gmt":"2018-12-04 03:48:02","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/chatterjee-3\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":28554,"post_author":"0","post_date":"2018-12-03 23:08:32","post_date_gmt":"2018-12-03 22:08:32","post_content":"","post_title":"Ulrike Peters","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"ulrike-peters","to_ping":"","pinged":"","post_modified":"2018-12-03 23:08:32","post_modified_gmt":"2018-12-03 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03:48:05","post_content":"","post_title":"Kirsh","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"kirsh","to_ping":"","pinged":"","post_modified":"2018-12-04 04:48:05","post_modified_gmt":"2018-12-04 03:48:05","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/kirsh\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":48921,"post_author":"0","post_date":"2018-12-04 04:48:06","post_date_gmt":"2018-12-04 03:48:06","post_content":"","post_title":"Urban","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"urban","to_ping":"","pinged":"","post_modified":"2018-12-04 04:48:06","post_modified_gmt":"2018-12-04 03:48:06","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/urban\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":48922,"post_author":"0","post_date":"2018-12-04 04:48:07","post_date_gmt":"2018-12-04 03:48:07","post_content":"","post_title":"Crawford","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"crawford-2","to_ping":"","pinged":"","post_modified":"2018-12-04 04:48:07","post_modified_gmt":"2018-12-04 03:48:07","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/crawford-2\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":1195,"post_author":"0","post_date":"2018-12-03 15:57:12","post_date_gmt":"2018-12-03 14:57:12","post_content":"","post_title":"CANCER EPIDEMIOLOGY, BIOMARKERS AND 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