{"id":48657,"date":"2006-06-01T00:00:00","date_gmt":"2018-12-04T03:40:15","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/suppression-of-colon-carcinogenesis-by-bioactive-compounds\/"},"modified":"2018-12-04T04:40:15","modified_gmt":"2018-12-04T03:40:15","slug":"suppression-of-colon-carcinogenesis-by-bioactive-compounds","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/suppression-of-colon-carcinogenesis-by-bioactive-compounds\/","title":{"rendered":"Suppression of colon carcinogenesis by bioactive compounds in grapefruit."},"content":{"rendered":"<p style=\"text-align: justify\">This study evaluated the hypothesis that untreated and irradiated grapefruit as well as the isolated citrus compounds naringin and limonin would protect against azoxymethane (AOM)-induced aberrant crypt foci (ACF) by suppressing proliferation and elevating apoptosis through anti-inflammatory activities. Male Sprague-Dawley rats (n = 100) were provided one of five diets: control (without added grapefruit components), untreated or irradiated (300 Gy, 137Cs) grapefruit pulp powder (13.7 g\/kg), naringin (200 mg\/kg) or limonin (200 mg\/kg). Rats were injected with saline or AOM (15 mg\/kg) during the third and fourth week and colons were resected (6 weeks post second injection) for evaluation of ACF, proliferation, apoptosis, and cyclooxygenase (COX)-2 and inducible nitric oxide synthase (iNOS) protein levels. Experimental diets had no effect on the variables measured in saline-injected rats. However, in AOM-injected rats, the experimental diets suppressed (P &lt; or = 0.02) aberrant crypt and high multiplicity ACF (HMACF; P &lt; or = 0.01) formation and the proliferative index (P &lt; or = 0.02) compared with the control diet. Only untreated grapefruit and limonin suppressed (P &lt; or = 0.04) HMACF\/cm and expansion (P &lt; or = 0.008) of the proliferative zone that occurred in the AOM-injected rats consuming the control diet. All diets elevated (P &lt; or = 0.05) the apoptotic index in AOM-injected rats, compared with the control diet; however, the greatest enhancement was seen with untreated grapefruit and limonin. Untreated grapefruit and limonin diets suppressed elevation of both iNOS (P &lt; or = 0.003) and COX-2 (P &lt; or = 0.032) levels observed in AOM-injected rats consuming the control diet. Although irradiated grapefruit and naringin suppressed iNOS levels in AOM-injected rats, no effect was observed with respect to COX-2 levels. Thus, lower levels of iNOS and COX-2 are associated with suppression of proliferation and upregulation of apoptosis, which may have contributed to a decrease in the number of HMACF in rats provided with untreated grapefruit and limonin. These results suggest that consumption of grapefruit or limonin may help to suppress colon cancer development.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-48657","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Department of Nutrition and Food Science, Texas A&M University, College Station, TX 77843, USA.","annee":"2006","mois":"6","numero":"27:6","page":"1257-65","auteurs":[{"ID":48649,"post_author":"0","post_date":"2018-12-04 04:40:03","post_date_gmt":"2018-12-04 03:40:03","post_content":"","post_title":"Bhimanagouda S Patil","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"bhimanagouda-s-patil","to_ping":"","pinged":"","post_modified":"2018-12-04 04:40:03","post_modified_gmt":"2018-12-04 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