{"id":48606,"date":"2006-07-01T00:00:00","date_gmt":"2018-12-04T03:38:53","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/effects-of-a-mediterranean-style-diet-on-cardiovascular-risk\/"},"modified":"2018-12-04T04:38:53","modified_gmt":"2018-12-04T03:38:53","slug":"effects-of-a-mediterranean-style-diet-on-cardiovascular-risk","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/effects-of-a-mediterranean-style-diet-on-cardiovascular-risk\/","title":{"rendered":"Effects of a mediterranean-style diet on cardiovascular risk factors: a randomized trial."},"content":{"rendered":"<p style=\"text-align: justify\"><strong>BACKGROUND: <\/strong>The Mediterranean diet has been shown to have beneficial effects on cardiovascular risk factors.<\/p>\n<p style=\"text-align: justify\"><strong>OBJECTIVE: <\/strong>To compare the short-term effects of 2 Mediterranean diets versus those of a low-fat diet on intermediate markers of cardiovascular risk.<\/p>\n<p style=\"text-align: justify\"><strong>DESIGN:<\/strong> Substudy of a multicenter, randomized, primary prevention trial of cardiovascular disease (Prevencion con Dieta Mediterranea [PREDIMED] Study).<\/p>\n<p style=\"text-align: justify\"><strong>SETTING: <\/strong>Primary care centers affiliated with 10 teaching hospitals.<\/p>\n<p style=\"text-align: justify\"><strong>PARTICIPANTS:<\/strong> 772 asymptomatic persons 55 to 80 years of age at high cardiovascular risk who were recruited from October 2003 to March 2004. Interventions: Participants were assigned to a low-fat diet (n = 257) or to 1 of 2 Mediterranean diets. Those allocated to Mediterranean diets received nutritional education and either free virgin olive oil, 1 liter per week (n = 257), or free nuts, 30 g\/d (n = 258). The authors evaluated outcome changes at 3 months.<\/p>\n<p style=\"text-align: justify\"><strong>MEASUREMENTS: <\/strong>Body weight, blood pressure, lipid profile, glucose levels, and inflammatory molecules.<\/p>\n<p style=\"text-align: justify\"><strong>RESULTS:<\/strong> The completion rate was 99.6%. Compared with the low-fat diet, the 2 Mediterranean diets produced beneficial changes in most outcomes. Compared with the low-fat diet, the mean changes in the Mediterranean diet with olive oil group and the Mediterranean diet with nuts group were -0.39 mmol\/L (95% CI, -0.70 to -0.07 mmol\/L) and -0.30 mmol\/L (CI, -0.58 to -0.01 mmol\/L), respectively, for plasma glucose levels; -5.9 mm Hg (CI, -8.7 to -3.1 mm Hg) and -7.1 mm Hg (CI, -10.0 to -4.1 mm Hg), respectively, for systolic blood pressure; and -0.38 (CI, -0.55 to -0.22) and &#8211; 0.26 (CI, -0.42 to -0.10), respectively, for the cholesterol-high-density lipoprotein cholesterol ratio. The Mediterranean diet with olive oil reduced C-reactive protein levels by 0.54 mg\/L (CI, 1.04 to 0.03 mg\/L) compared with the low-fat diet.<\/p>\n<p style=\"text-align: justify\"><strong>LIMITATIONS:<\/strong> This short-term study did not focus on clinical outcomes. Nutritional education about low-fat diet was less intense than education about Mediterranean diets.<\/p>\n<p style=\"text-align: justify\"><strong>CONCLUSION:<\/strong> Compared with a low-fat diet, Mediterranean diets supplemented with olive oil or nuts have beneficial effects on cardiovascular risk factors.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-48606","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Institut d'Investigacions Biomediques August Pi Sunyer, Municipal Institut for Medical Research, University of Barcelona, and Catalan Institute of Health, Barcelona, Spain. restruch@clinic.ub.es","annee":"2006","mois":"7","numero":"145:1","page":"1-11","auteurs":[{"ID":1164,"post_author":"0","post_date":"2018-12-03 15:56:56","post_date_gmt":"2018-12-03 14:56:56","post_content":"","post_title":"Ram\u00f3n 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