{"id":47584,"date":"2007-01-01T00:00:00","date_gmt":"2018-12-04T03:19:17","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/the-chronic-intake-of-a-mediterranean-diet-enriched-in-virgin\/"},"modified":"2018-12-04T04:19:17","modified_gmt":"2018-12-04T03:19:17","slug":"the-chronic-intake-of-a-mediterranean-diet-enriched-in-virgin","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/the-chronic-intake-of-a-mediterranean-diet-enriched-in-virgin\/","title":{"rendered":"The chronic intake of a mediterranean diet enriched in virgin olive oil, decreases nuclear transcription factor kappab activation in peripheral blood mononuclear cells from healthy men."},"content":{"rendered":"<p>OBJETIVE: Nuclear transcription factor kappaB (NF-kappaB) plays a key role in the inflammatory response and can be modulate by dietary fat. We have examined the effect of three diets, with different fat composition, on the activation of NF-kappaB on peripheral blood mononuclear cells (PBMCs). METHODS: Sixteen healthy men followed three 4-week diets, in a randomised crossover design: a Western diet, rich in saturated fat (SFA) [22% SFA, 12% monounsaturated fat (MUFA) and 0, 4 alpha-linolenic acid]; a Mediterranean diet [&lt;10% SFA, 24% MUFA and 0.4% alpha-linolenic acid], and a low fat diet enriched in alpha-linolenic acid [&lt;10% SFA, 12% MUFA and 2% alpha-linolenic acid]. NF-kappaB (electrophoretic mobility shift assay) in mononuclear cells and plasma concentrations (ELISA) of soluble vascular cellular adhesion molecule 1 (VCAM-1) were examined after either diets. RESULTS: Western diet increased 2.7-fold NF-kappaB compared with the Mediterranean diet (p=0.038) and 1.79-fold with the alpha-linolenic acid diet (p=0.07). No differences were found between the last two. Furthermore, an increase on plasma VCAM-1 was observed with the Western diet (p&lt;0.05). CONCLUSIONS: The Mediterranean diet diminished NF-kappaB activation in mononuclear cells, compared with Western diet, supporting its cardioprotective properties. The effect of the n-3 enriched diet was intermediate.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-47584","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Lipids and Atherosclerosis Research Unit, Hospital Universitario Reina Sofia, Avenida Menendez Pidal s\/n, 14004-Cordoba, Spain.","annee":"2007","mois":"1","numero":"2","page":"","auteurs":[{"ID":9286,"post_author":"0","post_date":"2018-12-03 18:09:27","post_date_gmt":"2018-12-03 17:09:27","post_content":"","post_title":"Pablo Perez-Martinez","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"pablo-perez-martinez","to_ping":"","pinged":"","post_modified":"2018-12-03 18:09:27","post_modified_gmt":"2018-12-03 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Delgado-Lista","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"javier-delgado-lista","to_ping":"","pinged":"","post_modified":"2018-12-03 18:09:27","post_modified_gmt":"2018-12-03 17:09:27","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/javier-delgado-lista\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":47583,"post_author":"0","post_date":"2018-12-04 04:19:16","post_date_gmt":"2018-12-04 03:19:16","post_content":"","post_title":"Egido","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"egido","to_ping":"","pinged":"","post_modified":"2018-12-04 04:19:16","post_modified_gmt":"2018-12-04 03:19:16","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/egido\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":9287,"post_author":"0","post_date":"2018-12-03 18:09:28","post_date_gmt":"2018-12-03 17:09:28","post_content":"","post_title":"Francisco Perez-Jimenez","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"francisco-perez-jimenez","to_ping":"","pinged":"","post_modified":"2018-12-03 18:09:28","post_modified_gmt":"2018-12-03 17:09:28","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/francisco-perez-jimenez\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":4542,"post_author":"0","post_date":"2018-12-03 17:18:29","post_date_gmt":"2018-12-03 16:18:29","post_content":"","post_title":"Jose Lopez-Miranda","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"jose-lopez-miranda","to_ping":"","pinged":"","post_modified":"2018-12-03 17:18:29","post_modified_gmt":"2018-12-03 16:18:29","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/jose-lopez-miranda\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":4622,"post_author":"0","post_date":"2018-12-03 17:19:13","post_date_gmt":"2018-12-03 16:19:13","post_content":"","post_title":"Atherosclerosis","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"atherosclerosis","to_ping":"","pinged":"","post_modified":"2018-12-03 17:19:13","post_modified_gmt":"2018-12-03 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