{"id":47430,"date":"2007-04-01T00:00:00","date_gmt":"2018-12-04T03:17:16","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/ugt1a1-polymorphism-is-associated-with-serum-bilirubin-concentrations\/"},"modified":"2018-12-04T04:17:16","modified_gmt":"2018-12-04T03:17:16","slug":"ugt1a1-polymorphism-is-associated-with-serum-bilirubin-concentrations","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/ugt1a1-polymorphism-is-associated-with-serum-bilirubin-concentrations\/","title":{"rendered":"Ugt1a1 polymorphism is associated with serum bilirubin concentrations in a randomized, controlled, fruit and vegetable feeding trial."},"content":{"rendered":"<p>UDP-glucuronosyltransferase (UGT) 1A1 glucuronidates bilirubin, estrogens, and exogenous compounds, including dietary carcinogens. The UGT1A1*28 polymorphism, characterized by variation in the number of thymine-adenine repeats in the promoter region, modulates UGT1A1 transcription. Observational and in vitro studies suggest that certain phytochemicals may increase UGT activity. We investigated, in a randomized, controlled, crossover feeding trial, whether approximately 10 servings\/d (doses adjusted for body weight) of crucifers, soy, and citrus for 2 wk compared with a fruit- and vegetable-free basal diet affected UGT1A1 activity as measured by serum bilirubin concentrations and whether effects were modulated by the UGT1A1*28 polymorphism. Healthy men (n = 32) and women (n = 31), aged 20-40 y, enrolled based on UGT1A1 genotype, completed the study. We measured bilirubin in blood collected at d 8 and d 15 of each feeding period. Overall, fruit and vegetables (F&amp;V) did not affect serum bilirubin; however, among 7\/7 individuals, d 8 total (P = 0.057) and indirect (unconjugated) (P = 0.051) bilirubin tended to be lower when individuals consumed the F&amp;V diet (28.97 +\/- 2.36 micromol\/L and 25.97 +\/- 2.15 micromol\/L) compared with the basal diet (32.46 +\/- 2.63 micromol\/L and 29.31 +\/- 2.43 micromol\/L). We no longer detected this difference at d 15, by which time bilirubin had also decreased when participants consumed the basal diet. Additionally, intervention effects on bilirubin were restricted to women with 7\/7 genotype (P = 0.002). These results suggest that serum bilirubin glucuronidation is modulated by dietary intervention, but factors such as UGT1A1 genotype and sex may affect the response to diet.<\/p>\n<p>PMID: 17374650 [PubMed &#8211; indexed <\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-47430","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Interdisciplinary Graduate Program in Nutritional Sciences, Department of Epidemiology, University of Washington, Seattle, WA 98195, USA.","annee":"2007","mois":"4","numero":"137:4","page":"890-7","auteurs":[{"ID":8185,"post_author":"0","post_date":"2018-12-03 17:57:20","post_date_gmt":"2018-12-03 16:57:20","post_content":"","post_title":"Johanna W Lampe","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"johanna-w-lampe","to_ping":"","pinged":"","post_modified":"2018-12-03 17:57:20","post_modified_gmt":"2018-12-03 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01:23:34","post_content":"","post_title":"King","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"king-2","to_ping":"","pinged":"","post_modified":"2018-12-04 02:23:34","post_modified_gmt":"2018-12-04 01:23:34","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/king-2\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":47077,"post_author":"0","post_date":"2018-12-04 04:11:44","post_date_gmt":"2018-12-04 03:11:44","post_content":"","post_title":"Lian","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"lian","to_ping":"","pinged":"","post_modified":"2018-12-04 04:11:44","post_modified_gmt":"2018-12-04 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01:40:02","post_content":"","post_title":"Chang","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"chang-3","to_ping":"","pinged":"","post_modified":"2018-12-04 02:40:02","post_modified_gmt":"2018-12-04 01:40:02","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/chang-3\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":8183,"post_author":"0","post_date":"2018-12-03 17:57:19","post_date_gmt":"2018-12-03 16:57:19","post_content":"","post_title":"Yvonne Schwarz","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"yvonne-schwarz","to_ping":"","pinged":"","post_modified":"2018-12-03 17:57:19","post_modified_gmt":"2018-12-03 16:57:19","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/yvonne-schwarz\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":41957,"post_author":"0","post_date":"2018-12-04 02:41:18","post_date_gmt":"2018-12-04 01:41:18","post_content":"","post_title":"Gilliland","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"gilliland","to_ping":"","pinged":"","post_modified":"2018-12-04 02:41:18","post_modified_gmt":"2018-12-04 01:41:18","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/gilliland\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":32402,"post_author":"0","post_date":"2018-12-03 23:58:36","post_date_gmt":"2018-12-03 22:58:36","post_content":"","post_title":"J NUTR","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"j-nutr-2","to_ping":"","pinged":"","post_modified":"2018-12-03 23:58:36","post_modified_gmt":"2018-12-03 22:58:36","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/j-nutr-2\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Ugt1a1 polymorphism is associated with serum bilirubin concentrations in a randomized, controlled, fruit and vegetable feeding trial. - Aprifel<\/title>\n<meta name=\"description\" content=\"Ugt1a1 polymorphism is associated with serum bilirubin concentrations in a randomized, controlled, fruit and vegetable feeding trial. - Aprifel\" \/>\n<meta name=\"robots\" content=\"noindex, 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