{"id":47262,"date":"2007-06-01T00:00:00","date_gmt":"2018-12-04T03:14:46","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/the-effects-of-a-high-fruit-and-vegetable-high-fiber-low-fat\/"},"modified":"2018-12-04T04:14:46","modified_gmt":"2018-12-04T03:14:46","slug":"the-effects-of-a-high-fruit-and-vegetable-high-fiber-low-fat","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/the-effects-of-a-high-fruit-and-vegetable-high-fiber-low-fat\/","title":{"rendered":"The effects of a high-fruit and -vegetable, high-fiber, low-fat dietary intervention on serum concentrations of insulin, glucose, igf-i and igfbp-3"},"content":{"rendered":"<p>Objective:To determine the effects of dietary change on serum concentrations of insulin, glucose, IGF-I and IGFBP-3.<\/p>\n<p>Subjects:From among participants in a randomized clinical trial of men and women without a history of diabetes who were 35 years old or older and who had at least one histologically confirmed colorectal adenoma removed during a qualifying colonoscopy within the 6 months before randomization, 750 subjects were selected for this analysis.<\/p>\n<p>Methods:The authors analyzed fasting serum from 375 subjects with and 375 subjects without a recurrent polyp among participants in a randomized trial of a low-fat (20% of energy), high-fiber (18 g per 1000 kcals of energy intake) and high-fruit and -vegetable (5-8 servings per day) dietary intervention.Results:After 4 years of follow-up, IGF-I concentration in the intervention group (N=248) declined by 8.86 ng\/ml (initial mean of 133 ng\/ml) and 7.74 ng\/ml (initial mean value of 139 ng\/ml) in the non-intervention group (N=502). Based on an unpaired t-test, these declines were both statistically significant, but the difference between groups for the decline in IGF-I (1.12 ng\/ml ((95% confidence interval, 3.24 to 5.48)) was not. After 4 years, concentrations of IGFBP-3, insulin and glucose were not statistically different from values at baseline, and there were no differences in these serum measures between the intervention and control groups. In analysis restricted to lean (body mass index &lt;25 kg\/m2) subjects only, however, glucose concentrations in the intervention group decreased by 0.28 mmol\/l, while they increased in the control group by 0.01 mmol\/l (t-test for mean differences P=0.0003) over 4 years.<\/p>\n<p>Conclusions:A low-fat, high-fiber, high-fruit and -vegetable dietary intervention had minimal impact on serum concentrations of insulin, glucose, IGF-I and IGFBP-3 overall, but in lean subjects the intervention resulted in a significant reduction in serum glucose concentration.European Journal of Clinical Nutrition advance online publication, 9 May 2007; doi:10.1038\/sj.ejcn.1602726 <\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-47262","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"1Division of Epidemiology, University of Minnesota, Minneapolis, MN, USA\r\n2Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, MD, USA\r\n3Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA\r\n4Information Management Services, Inc., Silver Spring, MD, USA\r\n5Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA\r\n6Maine Center for Osteoporosis Research and Education, Bangor, ME, USA\r\n7Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA\r\n3Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA\r\n\r\n","annee":"2007","mois":"6","numero":"","page":"","auteurs":[{"ID":12161,"post_author":"0","post_date":"2018-12-03 18:43:26","post_date_gmt":"2018-12-03 17:43:26","post_content":"","post_title":"Lisa L Kahle","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"lisa-l-kahle","to_ping":"","pinged":"","post_modified":"2018-12-03 18:43:26","post_modified_gmt":"2018-12-03 17:43:26","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/lisa-l-kahle\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":45035,"post_author":"0","post_date":"2018-12-04 03:35:51","post_date_gmt":"2018-12-04 02:35:51","post_content":"","post_title":"Schatzkin","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"schatzkin","to_ping":"","pinged":"","post_modified":"2018-12-04 03:35:51","post_modified_gmt":"2018-12-04 02:35:51","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/schatzkin\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":40189,"post_author":"0","post_date":"2018-12-04 02:10:21","post_date_gmt":"2018-12-04 01:10:21","post_content":"","post_title":"Lanza","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"lanza","to_ping":"","pinged":"","post_modified":"2018-12-04 02:10:21","post_modified_gmt":"2018-12-04 01:10:21","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/lanza\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":36483,"post_author":"0","post_date":"2018-12-04 01:00:55","post_date_gmt":"2018-12-04 00:00:55","post_content":"","post_title":"Flood","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"flood","to_ping":"","pinged":"","post_modified":"2018-12-04 01:00:55","post_modified_gmt":"2018-12-04 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03:14:44","post_content":"","post_title":"Pfeiffer","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"pfeiffer-2","to_ping":"","pinged":"","post_modified":"2018-12-04 04:14:44","post_modified_gmt":"2018-12-04 03:14:44","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/pfeiffer-2\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":47260,"post_author":"0","post_date":"2018-12-04 04:14:45","post_date_gmt":"2018-12-04 03:14:45","post_content":"","post_title":"Remaley","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"remaley","to_ping":"","pinged":"","post_modified":"2018-12-04 04:14:45","post_modified_gmt":"2018-12-04 03:14:45","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/remaley\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":47261,"post_author":"0","post_date":"2018-12-04 04:14:45","post_date_gmt":"2018-12-04 03:14:45","post_content":"","post_title":"Rosen","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"rosen","to_ping":"","pinged":"","post_modified":"2018-12-04 04:14:45","post_modified_gmt":"2018-12-04 03:14:45","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/rosen\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":46207,"post_author":"0","post_date":"2018-12-04 03:53:30","post_date_gmt":"2018-12-04 02:53:30","post_content":"","post_title":"EUROPEAN JOURNAL OF CLINICAL NUTRITION EFIRST","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"european-journal-of-clinical-nutrition-efirst","to_ping":"","pinged":"","post_modified":"2018-12-04 03:53:30","post_modified_gmt":"2018-12-04 02:53:30","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/european-journal-of-clinical-nutrition-efirst\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>The effects of a high-fruit and -vegetable, high-fiber, low-fat dietary intervention on serum concentrations of insulin, glucose, igf-i and igfbp-3 - Aprifel<\/title>\n<meta name=\"description\" content=\"The effects of a high-fruit and -vegetable, high-fiber, low-fat dietary intervention on serum 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