Diabetes is associated with increased oxidative stress and atherosclerosis development. In the present study, we investigated the effects of pomegranate juice (PJ; which contains sugars and potent anti-oxidants) consumption by diabetic patients on blood diabetic parameters, and on oxidative stress in their serum and macrophages. Ten healthy subjects (controls) and 10 non-insulin dependent diabetes mellitus (NIDDM) patients who consumed PJ (50ml per day for 3 months) participated in the study. In the patients versus controls serum levels of lipid peroxides and thiobarbituric acid reactive substances (TBARS) were both increased, by 350% and 51%, respectively, whereas serum SH groups content and paraoxonase 1 (PON1) activity, were both decreased (by 23%). PJ consumption did not affect serum glucose, cholesterol and triglyceride levels, but it resulted in a significant reduction in serum lipid peroxides and TBARS levels by 56% and 28%, whereas serum SH groups and PON1 activity significantly increased by 12% and 24%, respectively. In the patients versus controls monocytes-derived macrophages (HMDM), we observed increased level of cellular peroxides (by 36%), and decreased glutathione content (by 64%). PJ consumption significantly reduced cellular peroxides (by 71%), and increased glutathione levels (by 141%) in the patients' HMDM. The patients' versus control HMDM took up oxidized LDL (Ox-LDL) at enhanced rate (by 37%) and PJ consumption significantly decreased the extent of Ox-LDL cellular uptake (by 39%). We thus conclude that PJ consumption by diabetic patients did not worsen the diabetic parameters, but rather resulted in anti-oxidative effects on serum and macrophages, which could contribute to attenuation of atherosclerosis development in these patients.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-46852","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, 31096 Haifa, Israel.","annee":"2006","mois":"8","numero":"187:2","page":"363-71","auteurs":[{"ID":28291,"post_author":"0","post_date":"2018-12-03 23:04:57","post_date_gmt":"2018-12-03 22:04:57","post_content":"","post_title":"Michael Aviram","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"michael-aviram","to_ping":"","pinged":"","post_modified":"2018-12-03 23:04:57","post_modified_gmt":"2018-12-03 22:04:57","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/michael-aviram\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":28290,"post_author":"0","post_date":"2018-12-03 23:04:56","post_date_gmt":"2018-12-03 22:04:56","post_content":"","post_title":"Mira Rosenblat","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"mira-rosenblat","to_ping":"","pinged":"","post_modified":"2018-12-03 23:04:56","post_modified_gmt":"2018-12-03 22:04:56","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/mira-rosenblat\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":46851,"post_author":"0","post_date":"2018-12-04 04:08:06","post_date_gmt":"2018-12-04 03:08:06","post_content":"","post_title":"Hayek","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"hayek-2","to_ping":"","pinged":"","post_modified":"2018-12-04 04:08:06","post_modified_gmt":"2018-12-04 03:08:06","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/hayek-2\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":4622,"post_author":"0","post_date":"2018-12-03 17:19:13","post_date_gmt":"2018-12-03 16:19:13","post_content":"","post_title":"Atherosclerosis","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"atherosclerosis","to_ping":"","pinged":"","post_modified":"2018-12-03 17:19:13","post_modified_gmt":"2018-12-03 16:19:13","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/atherosclerosis\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"\n