{"id":46733,"date":"2007-07-01T00:00:00","date_gmt":"2018-12-04T03:06:21","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/effects-of-high-fruit-vegetable-andor-low-fat-intervention\/"},"modified":"2018-12-04T04:06:21","modified_gmt":"2018-12-04T03:06:21","slug":"effects-of-high-fruit-vegetable-andor-low-fat-intervention","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/effects-of-high-fruit-vegetable-andor-low-fat-intervention\/","title":{"rendered":"Effects of high fruit-vegetable and\/or low-fat intervention on breast nipple aspirate fluid micronutrient levels."},"content":{"rendered":"<p>BACKGROUND: A change in diet is known to affect micronutrient levels in blood but to what extent diet can affect micronutrient levels in the breast is not yet well established. METHODS: Healthy, premenopausal women with a family history of breast cancer were randomized across four diet arms for 1 year in a 2 x 2 factorial design study: control, low-fat, high fruit-vegetable, and combination low-fat\/high fruit-vegetable diets. Subjects were asked to collect breast nipple aspirate fluid (NAF) at 0, 6, and 12 months, and levels of micronutrients were measured in the fluid. RESULTS: A total of 122 women were enrolled, 97 were retained for 12 months, and sufficient NAF for analysis was available from 59 women at baseline, 49 at 6 months, and 50 at 12 months. Repeated measures mixed-model ANOVA was used to model the data using cholesterol levels and lactation duration as covariates, where appropriate. The high fruit-vegetable intervention, regardless of fat intake, significantly increased total carotenoid levels in NAF. In the low-fat arm, levels of total carotenoids decreased over time relative to control. Levels of total tocopherols and retinol did not change significantly. Levels of 15-F(2t)-isoprostane, a marker of lipid peroxidation, also did not change significantly over time, although there was a decrease observed in the combination arm. CONCLUSIONS: These results indicate that total carotenoid levels in NAF can be significantly increased in the breast NAF with a high fruit-vegetable diet. A low-fat diet that was achieved with little increase in fruit and vegetable intake, however, decreased NAF carotenoid levels.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-46733","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Department of Family Medicine, University of Michigan, Room 2150 Cancer and Geriatrics Center, Ann Arbor, MI 48109-0930, USA. zoralong@umich.edu","annee":"2007","mois":"7","numero":"16:7","page":"1393-9","auteurs":[{"ID":41882,"post_author":"0","post_date":"2018-12-04 02:40:01","post_date_gmt":"2018-12-04 01:40:01","post_content":"","post_title":"Gang Chen","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"gang-chen","to_ping":"","pinged":"","post_modified":"2018-12-04 02:40:01","post_modified_gmt":"2018-12-04 01:40:01","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/gang-chen\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":46729,"post_author":"0","post_date":"2018-12-04 04:06:16","post_date_gmt":"2018-12-04 03:06:16","post_content":"","post_title":"Heilbrun","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"heilbrun","to_ping":"","pinged":"","post_modified":"2018-12-04 04:06:16","post_modified_gmt":"2018-12-04 03:06:16","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/heilbrun\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":46730,"post_author":"0","post_date":"2018-12-04 04:06:17","post_date_gmt":"2018-12-04 03:06:17","post_content":"","post_title":"Kucuk","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"kucuk","to_ping":"","pinged":"","post_modified":"2018-12-04 04:06:17","post_modified_gmt":"2018-12-04 03:06:17","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/kucuk\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":43789,"post_author":"0","post_date":"2018-12-04 03:12:29","post_date_gmt":"2018-12-04 02:12:29","post_content":"","post_title":"Jurenka","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"jurenka","to_ping":"","pinged":"","post_modified":"2018-12-04 03:12:29","post_modified_gmt":"2018-12-04 02:12:29","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/jurenka\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":46731,"post_author":"0","post_date":"2018-12-04 04:06:19","post_date_gmt":"2018-12-04 03:06:19","post_content":"","post_title":"Venkatranamoorthy","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"venkatranamoorthy","to_ping":"","pinged":"","post_modified":"2018-12-04 04:06:19","post_modified_gmt":"2018-12-04 03:06:19","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/venkatranamoorthy\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":46732,"post_author":"0","post_date":"2018-12-04 04:06:21","post_date_gmt":"2018-12-04 03:06:21","post_content":"","post_title":"Covington","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"covington","to_ping":"","pinged":"","post_modified":"2018-12-04 04:06:21","post_modified_gmt":"2018-12-04 03:06:21","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/covington\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":1195,"post_author":"0","post_date":"2018-12-03 15:57:12","post_date_gmt":"2018-12-03 14:57:12","post_content":"","post_title":"CANCER EPIDEMIOLOGY, BIOMARKERS AND PREVENTION","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"cancer-epidemiology-biomarkers-and-prevention","to_ping":"","pinged":"","post_modified":"2018-12-03 15:57:12","post_modified_gmt":"2018-12-03 14:57:12","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/cancer-epidemiology-biomarkers-and-prevention\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - 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