{"id":46514,"date":"2006-01-01T00:00:00","date_gmt":"2018-12-04T03:00:26","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/mediterranean-diet-olive-oil-and-cancer\/"},"modified":"2018-12-04T04:00:26","modified_gmt":"2018-12-04T03:00:26","slug":"mediterranean-diet-olive-oil-and-cancer","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/mediterranean-diet-olive-oil-and-cancer\/","title":{"rendered":"Mediterranean diet, olive oil and cancer"},"content":{"rendered":"

Olive oil is an integral ingredient of the \u00ab\u00a0Mediterranean diet\u00a0\u00bb and accumulating evidence suggests that it may have a potential role in lowering the risk of several types of cancers. The mechanisms by which the cancer-preventing effects of olive oil can be performed, however, are not known. We recently hypothesized that a novel molecular explanation concerning the anti-cancer actions of olive oil may relate to the ability of its monounsaturated fatty acid (MUFA) oleic acid (OA; 18:1n-9) to specifically regulate cancer-related oncogenes. Supporting our hypothesis, exogenous supplementation of cultured breast cancer cells with physiological concentrations of OA was found to suppress the overexpression of HER2 (Her-2\/neu, erbB-2), a well-characterized oncogene playing a key role in the etiology, progression and response to chemotherapy and endocrine therapy in approximately 20% of breast carcinomas. OA treatment was also found to synergistically enhance the efficacy of trastuzumab, a humanized monoclonal antibody binding with high affinity to the ectodomain (ECD) of the Her2-coded p185(HER2) oncoprotein. Moreover, OA exposure significantly diminished the proteolytic cleavage of the ECD of HER2 and, consequently, its activation status, a crucial molecular event that determines both the aggressive behavior and the response to trastuzumab of Her2-overexpressing breast carcinomas. Our most recent findings further reveal that OA exposure may suppresses HER2 at the transcriptional level by up-regulating the expression of the Ets protein PEA3 -a DNA-binding protein that specifically blocks HER2 promoter activity- in breast, ovarian and stomach cancer cell lines. This anti-HER2 property of OA offers a previously unrecognized molecular mechanism by which olive oil may regulate the malignant behavior of cancer cells. From a clinical perspective, it could provide an effective means of influencing the outcome of Her-2\/neu-overexpressing human carcinomas with poor prognosis. Indeed, OA-induced transcriptional repression of HER2 oncogene may represent a novel genomic explanation linking \u00ab\u00a0Mediterranean diet\u00a0\u00bb, olive oil and cancer as it seems to equally operate in various types of Her-2\/neu-related carcinomas.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-46514","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Medical Oncology, Institut Catala d'Oncologia, Hospital de Girona Dr. Josep Trueta, Girona, Spain. rcolomer@ico.scs.es\r\n","annee":"2006","mois":"1","numero":"8:1","page":"15-21","auteurs":[{"ID":46511,"post_author":"0","post_date":"2018-12-04 04:00:24","post_date_gmt":"2018-12-04 03:00:24","post_content":"","post_title":"Colomer","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"colomer","to_ping":"","pinged":"","post_modified":"2018-12-04 04:00:24","post_modified_gmt":"2018-12-04 03:00:24","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/colomer\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":46512,"post_author":"0","post_date":"2018-12-04 04:00:26","post_date_gmt":"2018-12-04 03:00:26","post_content":"","post_title":"Menendez","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"menendez","to_ping":"","pinged":"","post_modified":"2018-12-04 04:00:26","post_modified_gmt":"2018-12-04 03:00:26","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/menendez\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":46513,"post_author":"0","post_date":"2018-12-04 04:00:26","post_date_gmt":"2018-12-04 03:00:26","post_content":"","post_title":"CLIN TRANSL ONCOL","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"clin-transl-oncol","to_ping":"","pinged":"","post_modified":"2018-12-04 04:00:26","post_modified_gmt":"2018-12-04 03:00:26","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/clin-transl-oncol\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"\nMediterranean diet, olive oil and cancer - 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