Abstract: Flavonoids are found in a variety of foods and have anticarcinogenic properties in experimental models. Few epidemiologic studies have examined whether flavonoid intake is associated with breast cancer in humans. In this study, the authors investigated whether dietary flavonoid intake was associated with reduced risk of breast cancer in a population-based sample of US women. They conducted a case-control study among women who resided in Nassau and Suffolk counties on Long Island, New York. Cases and controls were interviewed about known and suspected risk factors and asked to complete a food frequency questionnaire regarding their average intake in the prior 12 months. A total of 1,434 breast cancer cases and 1,440 controls provided adequate responses. A decrease in breast cancer risk was associated with flavonoid intake; the decrease was most pronounced among postmenopausal women for flavonols (odds ratio (OR) = 0.54, 95% confidence interval (CI): 0.40, 0.73), flavones (OR = 0.61, 95% CI: 0.45, 0.83), flavan-3-ols (OR = 0.74, 95% CI: 0.55, 0.99), and lignans (OR = 0.69, 95% CI: 0.51, 0.94). The authors conclude that intake of flavonols, flavones, flavan-3-ols, and lignans is associated with reduced risk of incident postmenopausal breast cancer among Long Island women. These results suggest that US women can consume sufficient levels of flavonoids to benefit from their potential chemopreventive effects. <\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-46447","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Addresses: Fink BN (reprint author), Univ N Carolina, Dept Epidemiol, Sch Publ Hlth, Cb 7435,McGavran Greenberg Hall, Chapel Hill, NC 27599 USA\r\nUniv N Carolina, Dept Epidemiol, Sch Publ Hlth, Chapel Hill, NC 27599 USA\r\nUniv N Carolina, Dept Nutr, Sch Publ Hlth, Chapel Hill, NC 27599 USA\r\nMt Sinai Sch Med, Dept Community & Prevent Med, New York, NY USA\r\nAlbert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA\r\nColumbia Univ, Joseph L Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY 10027 USA\r\nColumbia Univ, Coll Phys & Surg, Dept Med, New York, NY 10027 USA\r\n\r\nE-mail Addresses: 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