{"id":46425,"date":"2007-01-01T00:00:00","date_gmt":"2018-12-04T02:58:11","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/chemoprevention-of-aberrant-crypt-foci-in-the-colon-of-rats\/"},"modified":"2018-12-04T03:58:11","modified_gmt":"2018-12-04T02:58:11","slug":"chemoprevention-of-aberrant-crypt-foci-in-the-colon-of-rats","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/chemoprevention-of-aberrant-crypt-foci-in-the-colon-of-rats\/","title":{"rendered":"Chemoprevention of aberrant crypt foci in the colon of rats by dietary onion"},"content":{"rendered":"<p style=\"text-align: justify\">Onion intake might reduce the risk of colorectal cancer, according to epidemiology. However, Femia showed in 2003 that diets with a 20% onion intake increase carcinogenesis in rats. We speculated this dose was too high. Prevention of initiation was thus tested in 60 rats given a 5% dried onion diet or AIN76 diet, and initiated 12 days later with azoxymethane (AOM, 1 x 20 mg\/kg i.p.), 2-amino-3-methylimidazo[4,5-f]quinoline (IQ 2 x 200 mg\/ kg p.o.), or N-nitroso-N-methylurea (2 x 50 mg\/kg p.o.). Prevention of promotion was tested in 38 rats given AOM, then randomised to: AIN76 diet; 5% onion diet; phytochemicals diet (supplemented with propyl-disulfide, quercetine-glycosides and oligofructose); 1% pluronic F68 diet (a potent chemopreventive PEG-like block-polymer, used as a positive control). Aberrant crypt foci (ACF) were scored 30 days (initiation) or 100 days (promotion) after carcinogen injection. The onion diet given during initiation reduced the number of AOM-induced ACF (60 versus 86, p = 0.03), and the size of IQ-induced ACT (1.33 versus 1.97, p = 0.02). Given post-initiation, the onion diet reduced the number of ACF (34 versus 59, p = 0.008) and of large ACF (6 versus 15, p = 0.02). Phytochemicals diet and pluronic diet reduced ACF growth similarly Data show that a 5% onion diet reduced carcirrogenesis during initiation and promotion stages, and suggest this chemoprevention is due to known phytochemicals.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-46425","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Addresses: Corpet DE (reprint author), INRA, UMR 1089 Xenobiot, 23 Capelles, F-31076 Toulouse, France\r\nINRA, UMR 1089 Xenobiot, F-31076 Toulouse, France\r\nENVT, F-31076 Toulouse, France\r\n\r\nE-mail Addresses: d.corpet@envt.fr \r\n\r\nPublisher: ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND, http:\/\/www.elsevier.com \r\nDiscipline: ONCOLOGY\r\n","annee":"2007","mois":"1","numero":"43:2","page":"454-458","auteurs":[{"ID":46421,"post_author":"0","post_date":"2018-12-04 03:58:08","post_date_gmt":"2018-12-04 02:58:08","post_content":"","post_title":"Corpet","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"corpet","to_ping":"","pinged":"","post_modified":"2018-12-04 03:58:08","post_modified_gmt":"2018-12-04 02:58:08","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/corpet\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":46422,"post_author":"0","post_date":"2018-12-04 03:58:09","post_date_gmt":"2018-12-04 02:58:09","post_content":"","post_title":"Tache","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"tache","to_ping":"","pinged":"","post_modified":"2018-12-04 03:58:09","post_modified_gmt":"2018-12-04 02:58:09","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/tache\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":46423,"post_author":"0","post_date":"2018-12-04 03:58:10","post_date_gmt":"2018-12-04 02:58:10","post_content":"","post_title":"Ladam","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"ladam","to_ping":"","pinged":"","post_modified":"2018-12-04 03:58:10","post_modified_gmt":"2018-12-04 02:58:10","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/ladam\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":46424,"post_author":"0","post_date":"2018-12-04 03:58:11","post_date_gmt":"2018-12-04 02:58:11","post_content":"","post_title":"EUROPEAN JOURNAL OF CANCER","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"european-journal-of-cancer","to_ping":"","pinged":"","post_modified":"2018-12-04 03:58:11","post_modified_gmt":"2018-12-04 02:58:11","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/european-journal-of-cancer\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - 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