{"id":45569,"date":"2007-02-01T00:00:00","date_gmt":"2018-12-04T02:43:36","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/environmental-toxicity-nutrition-and-gene-interactions\/"},"modified":"2018-12-04T03:43:36","modified_gmt":"2018-12-04T02:43:36","slug":"environmental-toxicity-nutrition-and-gene-interactions","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/environmental-toxicity-nutrition-and-gene-interactions\/","title":{"rendered":"Environmental toxicity, nutrition, and gene interactions in the development of atherosclerosis"},"content":{"rendered":"<p>There is substantial evidence from epidemiological studies that the pathology of cardiovascular diseases is linked in part to environmental pollution. Many environmental contaminants, and especially persistent organic pollutants, are risk factors for atherosclerosis because they may exacerbate an underlying disease by altering gene expression patterns. Many mechanisms and signaling pathways associated with the pathology of \u00ab\u00a0modern\u00a0\u00bb diseases are similarly modulated by poor dietary habits and environmental pollutants. Many genes induced in diseases associated with vascular dysfunction such as atherosclerosis are oxidative stress-sensitive, suggesting that an imbalance in cellular oxidative stress and antioxidant status is a critical underlying factor. One of the emerging issues in modern toxicological sciences is the modification of environmental toxicity by nutrients. Evidence is emerging which suggests that antioxidant nutrients and related bioactive compounds common in fruits and vegetables protect against environmental toxic insult to the vascular endothelium by down-regulation of signaling pathways involved in inflammatory responses associated with vascular diseases such as atherosclerosis. Thus, the concept that nutrition may modify or ameliorate the toxicity of environmental chemicals may have implications for understanding the complex interaction of environmental toxicity and disease development.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-45569","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Molecular and Cell Nutrition Laboratory, College of Agriculture, University of Kentucky, Room 591, Wethington Health Sciences Bldg., 900 S. Limestone, Lexington, KY 40536-0200, USA. bhennig@uky.edu <bhennig@uky.edu>","annee":"2007","mois":"2","numero":"17:2","page":"162-9","auteurs":[{"ID":45566,"post_author":"0","post_date":"2018-12-04 03:43:35","post_date_gmt":"2018-12-04 02:43:35","post_content":"","post_title":"Hennig","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"hennig","to_ping":"","pinged":"","post_modified":"2018-12-04 03:43:35","post_modified_gmt":"2018-12-04 02:43:35","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/hennig\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":45567,"post_author":"0","post_date":"2018-12-04 03:43:35","post_date_gmt":"2018-12-04 02:43:35","post_content":"","post_title":"Toborek","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"toborek","to_ping":"","pinged":"","post_modified":"2018-12-04 03:43:35","post_modified_gmt":"2018-12-04 02:43:35","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/toborek\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":45568,"post_author":"0","post_date":"2018-12-04 03:43:36","post_date_gmt":"2018-12-04 02:43:36","post_content":"","post_title":"Oesterling","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"oesterling","to_ping":"","pinged":"","post_modified":"2018-12-04 03:43:36","post_modified_gmt":"2018-12-04 02:43:36","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/oesterling\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":34286,"post_author":"0","post_date":"2018-12-04 00:26:29","post_date_gmt":"2018-12-03 23:26:29","post_content":"","post_title":"NUTR METAB CARDIOVASC DIS","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"nutr-metab-cardiovasc-dis","to_ping":"","pinged":"","post_modified":"2018-12-04 00:26:29","post_modified_gmt":"2018-12-03 23:26:29","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/nutr-metab-cardiovasc-dis\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Environmental toxicity, nutrition, and gene interactions in the development of atherosclerosis - Aprifel<\/title>\n<meta name=\"description\" content=\"Environmental toxicity, nutrition, and gene interactions in the development of atherosclerosis - Aprifel\" \/>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Environmental toxicity, nutrition, and gene interactions in the development of atherosclerosis\" \/>\n<meta property=\"og:description\" content=\"Environmental toxicity, nutrition, and gene interactions in the development of atherosclerosis\" \/>\n<meta property=\"og:url\" content=\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/environmental-toxicity-nutrition-and-gene-interactions\/\" \/>\n<meta property=\"og:site_name\" content=\"Aprifel\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/environmental-toxicity-nutrition-and-gene-interactions\/\",\"url\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/environmental-toxicity-nutrition-and-gene-interactions\/\",\"name\":\"Environmental toxicity, nutrition, and gene interactions in the development of atherosclerosis - Aprifel\",\"isPartOf\":{\"@id\":\"https:\/\/www.aprifel.com\/fr\/#website\"},\"datePublished\":\"2018-12-04T02:43:36+00:00\",\"dateModified\":\"2018-12-04T02:43:36+00:00\",\"description\":\"Environmental toxicity, nutrition, and gene interactions in the development of atherosclerosis - Aprifel\",\"breadcrumb\":{\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/environmental-toxicity-nutrition-and-gene-interactions\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/environmental-toxicity-nutrition-and-gene-interactions\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/environmental-toxicity-nutrition-and-gene-interactions\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/www.aprifel.com\/fr\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"R\u00e9sum\u00e9s\",\"item\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Environmental toxicity, nutrition, and gene interactions in the development of atherosclerosis\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.aprifel.com\/fr\/#website\",\"url\":\"https:\/\/www.aprifel.com\/fr\/\",\"name\":\"Aprifel\",\"description\":\"Agence pour la Recherche et l\u2019Information en Fruits et L\u00e9gumes\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.aprifel.com\/fr\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Environmental toxicity, nutrition, and gene interactions in the development of atherosclerosis - Aprifel","description":"Environmental toxicity, nutrition, and gene interactions in the development of atherosclerosis - Aprifel","robots":{"index":"noindex","follow":"follow"},"og_locale":"fr_FR","og_type":"article","og_title":"Environmental toxicity, nutrition, and gene interactions in the development of atherosclerosis","og_description":"Environmental toxicity, nutrition, and gene interactions in the development of atherosclerosis","og_url":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/environmental-toxicity-nutrition-and-gene-interactions\/","og_site_name":"Aprifel","twitter_card":"summary_large_image","twitter_misc":{"Dur\u00e9e de lecture estim\u00e9e":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/environmental-toxicity-nutrition-and-gene-interactions\/","url":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/environmental-toxicity-nutrition-and-gene-interactions\/","name":"Environmental toxicity, nutrition, and gene interactions in the development of atherosclerosis - Aprifel","isPartOf":{"@id":"https:\/\/www.aprifel.com\/fr\/#website"},"datePublished":"2018-12-04T02:43:36+00:00","dateModified":"2018-12-04T02:43:36+00:00","description":"Environmental toxicity, nutrition, and gene interactions in the development of atherosclerosis - Aprifel","breadcrumb":{"@id":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/environmental-toxicity-nutrition-and-gene-interactions\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/environmental-toxicity-nutrition-and-gene-interactions\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/environmental-toxicity-nutrition-and-gene-interactions\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/www.aprifel.com\/fr\/"},{"@type":"ListItem","position":2,"name":"R\u00e9sum\u00e9s","item":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/"},{"@type":"ListItem","position":3,"name":"Environmental toxicity, nutrition, and gene interactions in the development of atherosclerosis"}]},{"@type":"WebSite","@id":"https:\/\/www.aprifel.com\/fr\/#website","url":"https:\/\/www.aprifel.com\/fr\/","name":"Aprifel","description":"Agence pour la Recherche et l\u2019Information en Fruits et L\u00e9gumes","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.aprifel.com\/fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"}]}},"_links":{"self":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/resume\/45569"}],"collection":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/resume"}],"about":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/types\/resume"}],"wp:attachment":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/media?parent=45569"}],"wp:term":[{"taxonomy":"mots_cles","embeddable":true,"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/mots_cles?post=45569"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}