{"id":45436,"date":"2006-09-01T00:00:00","date_gmt":"2018-12-04T02:41:41","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/low-maternal-vitamin-e-intake-during-pregnancy-is-associated\/"},"modified":"2018-12-04T03:41:41","modified_gmt":"2018-12-04T02:41:41","slug":"low-maternal-vitamin-e-intake-during-pregnancy-is-associated","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/low-maternal-vitamin-e-intake-during-pregnancy-is-associated\/","title":{"rendered":"Low maternal vitamin e intake during pregnancy is associated with asthma in 5-year-old children"},"content":{"rendered":"<p>RATIONALE: We have previously reported an association between reduced maternal vitamin E intake during pregnancy and wheezing in 2-yr-old children. OBJECTIVES: To assess whether maternal nutrient intake during pregnancy is associated with asthma-related outcomes in children aged 5 yr. METHODS: A longitudinal cohort study of 1,861 children born to women recruited during pregnancy and followed up at 5 yr. MEASUREMENTS: Maternal nutrient status was assessed by a food frequency questionnaire and plasma levels. Respiratory and food frequency questionnaires were completed at 5 yr and children were invited for measurement of spirometry and skin-prick testing. MAIN RESULTS: Symptom and food frequency questionnaire data were available for 1,253 and 1,120 children, respectively; 700 children were skin prick tested, and FEV(1) was measured in 478 and exhaled nitric oxide in 167 children. In 5-yr-old children, maternal vitamin E intake during pregnancy was negatively associated with wheeze in previous year (odds ratio per intake quintile, 0.82; 95% confidence interval, 0.71-0.95), asthma ever (0.84, 0.72-0.98), asthma and wheeze in previous year (0.79, 0.65-0.95), and persistent wheezing (0.77, 0.63-0.93). Maternal plasma alpha-tocopherol during pregnancy was positively associated with post-bronchodilator FEV(1) at 5 yr, with a 7-ml (95% confidence interval, 0-14; p = 0.04) increase in FEV(1) per microg\/ml alpha-tocopherol. Maternal zinc intake during pregnancy was negatively associated with asthma ever (0.83, 0.71-0.78) and active asthma (0.72, 0.59-0.89). There were no associations between children&rsquo;s nutrient intake and respiratory outcomes. CONCLUSION: Maternal intake of foods containing vitamin E and zinc during pregnancy is associated with differences in the risks of developing childhood wheeze and asthma.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-45436","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Department of Environmental and Occupational Medicine, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZB, UK. g.devereux@abdn.ac.uk\r\n","annee":"2006","mois":"9","numero":"174:5","page":"499-507","auteurs":[{"ID":45431,"post_author":"0","post_date":"2018-12-04 03:41:37","post_date_gmt":"2018-12-04 02:41:37","post_content":"","post_title":"Seaton","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"seaton","to_ping":"","pinged":"","post_modified":"2018-12-04 03:41:37","post_modified_gmt":"2018-12-04 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Devereux","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"graham-devereux","to_ping":"","pinged":"","post_modified":"2018-12-03 23:39:47","post_modified_gmt":"2018-12-03 22:39:47","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/graham-devereux\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":45432,"post_author":"0","post_date":"2018-12-04 03:41:38","post_date_gmt":"2018-12-04 02:41:38","post_content":"","post_title":"Turner","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"turner-2","to_ping":"","pinged":"","post_modified":"2018-12-04 03:41:38","post_modified_gmt":"2018-12-04 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02:41:39","post_content":"","post_title":"Helms","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"helms","to_ping":"","pinged":"","post_modified":"2018-12-04 03:41:39","post_modified_gmt":"2018-12-04 02:41:39","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/helms\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":45434,"post_author":"0","post_date":"2018-12-04 03:41:39","post_date_gmt":"2018-12-04 02:41:39","post_content":"","post_title":"Martindale","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"martindale","to_ping":"","pinged":"","post_modified":"2018-12-04 03:41:39","post_modified_gmt":"2018-12-04 02:41:39","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/martindale\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":45435,"post_author":"0","post_date":"2018-12-04 03:41:40","post_date_gmt":"2018-12-04 02:41:40","post_content":"","post_title":"Harbour","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"harbour","to_ping":"","pinged":"","post_modified":"2018-12-04 03:41:40","post_modified_gmt":"2018-12-04 02:41:40","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/harbour\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":4895,"post_author":"0","post_date":"2018-12-03 17:22:03","post_date_gmt":"2018-12-03 16:22:03","post_content":"","post_title":"AMERICAN JOURNAL OF RESPIRATORY AND 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