{"id":45051,"date":"2008-04-01T00:00:00","date_gmt":"2018-12-04T02:36:06","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/folate-metabolism-genes-vegetable-intake-and-renal-cancer\/"},"modified":"2018-12-04T03:36:06","modified_gmt":"2018-12-04T02:36:06","slug":"folate-metabolism-genes-vegetable-intake-and-renal-cancer","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/folate-metabolism-genes-vegetable-intake-and-renal-cancer\/","title":{"rendered":"Folate metabolism genes, vegetable intake and renal cancer risk in central europe."},"content":{"rendered":"

In a multicenter case-control study of renal cell carcinoma (RCC) conducted in central and eastern Europe, we reported a strong inverse association with high vegetable intake and RCC risk. The odds ratio (OR) for high compared to the lowest tertile of vegetable intake was OR = 0.67; (95% confidence interval (CI): 0.53-0.83; p-trend T (rs234706), Ex13 +41C > T (rs1801181), Ex18 -391 G > A (rs12613); MTHFR: A222V Ex5+79C > T (rs1801133), Ex8-62A > C (rs1801131); MTR: Ex26 20A > G (rs1805087), MTRR: Ex5+136 T > C (rs161870), and TYMS:IVS2-405 C > T (rs502396), Ex8+157 C > T (rs699517), Ex8+227 A > G (rs2790)) were analyzed among 1,097 RCC cases and 1,555 controls genotyped in this study. Having at least 1 variant T allele of MTHFR A222V was associated with higher RCC risk compared to those with 2 common (CC) alleles (OR = 1.44; 95% CI: 1.17-1.77; p = 0.001). After stratification by tertile of vegetable intake, the higher risk associated with the variant genotype was only observed in the low and medium tertiles (p-trend = 0.001), but not among those in the highest tertile (p-interaction = 0.22). The association remained robust after calculation of the false discovery rate (FDR = 0.05). Of the 3 TYMS SNPs examined, only the TYMS IVS2 -405 C (rs502396) variant was associated with a significantly lower risk compared to the common genotype (OR = 0.73; 95% CI: 0.57-0.93). Vegetable intake modified the association between all 3 TYMS SNPs and RCC risk (p-interaction < 0.04 for all). In summary, these findings suggest that common variation in MTHFR and TYMS genes may be associated with RCC risk, particularly when vegetable intake is low.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-45051","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA. moorele@mail.nih.gov","annee":"2008","mois":"4","numero":"122:8","page":"1710-5","auteurs":[{"ID":39830,"post_author":"0","post_date":"2018-12-04 02:04:04","post_date_gmt":"2018-12-04 01:04:04","post_content":"","post_title":"Laurence Moore","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"laurence-moore","to_ping":"","pinged":"","post_modified":"2018-12-04 02:04:04","post_modified_gmt":"2018-12-04 01:04:04","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/laurence-moore\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":4092,"post_author":"0","post_date":"2018-12-03 17:12:19","post_date_gmt":"2018-12-03 16:12:19","post_content":"","post_title":"Paolo Boffetta","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"paolo-boffetta","to_ping":"","pinged":"","post_modified":"2018-12-03 17:12:19","post_modified_gmt":"2018-12-03 16:12:19","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/paolo-boffetta\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":28759,"post_author":"0","post_date":"2018-12-03 23:10:33","post_date_gmt":"2018-12-03 22:10:33","post_content":"","post_title":"Eoin P Brennan","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"eoin-p-brennan","to_ping":"","pinged":"","post_modified":"2018-12-03 23:10:33","post_modified_gmt":"2018-12-03 22:10:33","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/eoin-p-brennan\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":17808,"post_author":"0","post_date":"2018-12-03 19:56:45","post_date_gmt":"2018-12-03 18:56:45","post_content":"","post_title":"Nathaniel Rothman","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"nathaniel-rothman","to_ping":"","pinged":"","post_modified":"2018-12-03 19:56:45","post_modified_gmt":"2018-12-03 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