{"id":45009,"date":"2008-01-01T00:00:00","date_gmt":"2018-12-04T02:35:22","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/isolation-and-identification-of-strawberry-phenolics-with\/"},"modified":"2018-12-04T03:35:22","modified_gmt":"2018-12-04T02:35:22","slug":"isolation-and-identification-of-strawberry-phenolics-with","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/isolation-and-identification-of-strawberry-phenolics-with\/","title":{"rendered":"Isolation and identification of strawberry phenolics with antioxidant and human cancer cell antiproliferative properties."},"content":{"rendered":"<p style=\"text-align: justify\">Studies suggest that consumption of berry fruits, including strawberries ( Fragaria x ananassa Duch.), may have beneficial effects against oxidative stress mediated diseases such as cancer. Berries contain multiple phenolic compounds, which are thought to contribute to their biological properties. Comprehensive profiling of phenolics from strawberries was previously reported using high-performance liquid chromatography with mass spectrometry (HPLC-MS) detection. The current study reports the isolation and structural characterization of 10 phenolic compounds from strawberry extracts using a combination of Amberlite XAD16-resin and C18 columns, HPLC-UV, and nuclear magnetic resonance (NMR) spectroscopy methods. The phenolics were cyanidin-3-glucoside ( 1), pelargonidin (2), pelargonidin-3-glucoside (3), pelargonidin-3-rutinoside (4), kaempferol (5), quercetin (6), kaempferol-3-(6&#039;-coumaroyl)glucoside) (7), 3,4,5-trihydroxyphenyl-acrylic acid (8), glucose ester of ( E)- p-coumaric acid (9), and ellagic acid . Strawberry crude extracts and purified compounds 1- 10 were evaluated for antioxidant and human cancer cell antiproliferative activities by the Trolox equivalent antioxidant capacity (TEAC) and luminescent ATP cell viability assays, respectively. Among the pure compounds, the anthocyanins 1 (7156 &micro;M Trolox\/mg), 2 (4922 &micro;M Trolox\/mg), and 4 (5514 &micro;M Trolox\/mg) were the most potent antioxidants. Crude extracts (250 &micro;g\/mL) and pure compounds (100 &micro;g\/mL) inhibited the growth of human oral (CAL-27, KB), colon (HT29, HCT-116), and prostate (LNCaP, DU145) cancer cells with different sensitivities observed between cell lines. This study adds to the growing body of data supporting the bioactivities of berry fruit phenolics and their potential impact on human health.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-45009","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA.","annee":"2008","mois":"1","numero":"56:3","page":"670-5","auteurs":[{"ID":1647,"post_author":"0","post_date":"2018-12-03 16:01:16","post_date_gmt":"2018-12-03 15:01:16","post_content":"","post_title":"Navindra P Seeram","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"navindra-p-seeram","to_ping":"","pinged":"","post_modified":"2018-12-03 16:01:16","post_modified_gmt":"2018-12-03 15:01:16","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/navindra-p-seeram\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":34588,"post_author":"0","post_date":"2018-12-04 00:31:58","post_date_gmt":"2018-12-03 23:31:58","post_content":"","post_title":"Yang Zhang","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"yang-zhang","to_ping":"","pinged":"","post_modified":"2018-12-04 00:31:58","post_modified_gmt":"2018-12-03 23:31:58","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/yang-zhang\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":9344,"post_author":"0","post_date":"2018-12-03 18:10:06","post_date_gmt":"2018-12-03 17:10:06","post_content":"","post_title":"David Heber","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"david-heber","to_ping":"","pinged":"","post_modified":"2018-12-03 18:10:06","post_modified_gmt":"2018-12-03 17:10:06","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/david-heber\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":45008,"post_author":"0","post_date":"2018-12-04 03:35:21","post_date_gmt":"2018-12-04 02:35:21","post_content":"","post_title":"Lee","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"lee-13","to_ping":"","pinged":"","post_modified":"2018-12-04 03:35:21","post_modified_gmt":"2018-12-04 02:35:21","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/lee-13\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":32131,"post_author":"0","post_date":"2018-12-03 23:54:57","post_date_gmt":"2018-12-03 22:54:57","post_content":"","post_title":"Lei Feng","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"lei-feng","to_ping":"","pinged":"","post_modified":"2018-12-03 23:54:57","post_modified_gmt":"2018-12-03 22:54:57","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/lei-feng\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":34177,"post_author":"0","post_date":"2018-12-04 00:24:14","post_date_gmt":"2018-12-03 23:24:14","post_content":"","post_title":"J AGRIC FOOD CHEM","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"j-agric-food-chem-2","to_ping":"","pinged":"","post_modified":"2018-12-04 00:24:14","post_modified_gmt":"2018-12-03 23:24:14","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/j-agric-food-chem-2\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - 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