{"id":44896,"date":"2007-09-01T00:00:00","date_gmt":"2018-12-04T02:33:30","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/gstt1-genotype-modifies-the-association-between-cruciferous\/"},"modified":"2018-12-04T03:33:30","modified_gmt":"2018-12-04T02:33:30","slug":"gstt1-genotype-modifies-the-association-between-cruciferous","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/gstt1-genotype-modifies-the-association-between-cruciferous\/","title":{"rendered":"Gstt1 genotype modifies the association between cruciferous vegetable intake and the risk of myocardial infarction."},"content":{"rendered":"<p>BACKGROUND: Cruciferous vegetables are a major dietary source of isothiocyanates that may protect against coronary heart disease. Isothiocyanates induce glutathione S-transferases (GSTs), polymorphic genes that code for enzymes that conjugate isothiocyanates, as well as mutagens and reactive oxygen species, to make them more readily excretable. OBJECTIVE: The objective of the study was to determine whether GST genotypes modify the association between cruciferous vegetable intake and the risk of myocardial infarction (MI). DESIGN: Cases (n = 2042) with a first acute nonfatal MI and population-based controls (n = 2042) living in Costa Rica, who were matched for age, sex, and area of residence, were genotyped for a deletion polymorphism in GSTM1 and GSTT1 and an Ile105Val substitution in GSTP1. Cruciferous vegetable intake and smoking status were determined by questionnaire. Odds ratios (ORs) and 95% CIs for MI were estimated by unconditional logistic regression. RESULTS: Compared with the lowest tertile of cruciferous vegetable intake, the highest tertile was associated with a lower risk of MI among persons with the functional GSTT1*1 allele (OR: 0.70; 95% CI: 0.58, 0.84) but not among those with the GSTT1*0*0 genotype (OR: 1.23; 95% CI: 0.83, 1.82) (P = 0.006 for interaction). This protective effect among those with the GSTT1*1 allele was greater for current smokers (OR: 0.54; 95% CI: 0.36, 0.79) than for nonsmokers. GSTP1 and GSTM1 did not modify the association between cruciferous vegetable intake and MI. CONCLUSIONS: Consumption of cruciferous vegetables was associated with a lower risk of MI among those with a functional GSTT1*1 allele, which suggests that compounds that are detoxified by this enzyme contribute to the risk of MI.<\/p>\n<p>PMID: 17823442 [PubMed &#8211; indexed for MEDLINE]\n","protected":false},"template":"","mots_cles":[],"class_list":["post-44896","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Department of Nutritional Sciences, University of Toronto, Canada.","annee":"2007","mois":"9","numero":"86:3","page":"752-8","auteurs":[{"ID":22491,"post_author":"0","post_date":"2018-12-03 21:05:33","post_date_gmt":"2018-12-03 20:05:33","post_content":"","post_title":"Hannia Campos","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"hannia-campos","to_ping":"","pinged":"","post_modified":"2018-12-03 21:05:33","post_modified_gmt":"2018-12-03 20:05:33","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/hannia-campos\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":44895,"post_author":"0","post_date":"2018-12-04 03:33:29","post_date_gmt":"2018-12-04 02:33:29","post_content":"","post_title":"Cornelis","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"cornelis","to_ping":"","pinged":"","post_modified":"2018-12-04 03:33:29","post_modified_gmt":"2018-12-04 02:33:29","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/cornelis\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":12777,"post_author":"0","post_date":"2018-12-03 18:50:22","post_date_gmt":"2018-12-03 17:50:22","post_content":"","post_title":"Ahmed El-Sohemy","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"ahmed-el-sohemy","to_ping":"","pinged":"","post_modified":"2018-12-03 18:50:22","post_modified_gmt":"2018-12-03 17:50:22","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/ahmed-el-sohemy\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":1720,"post_author":"0","post_date":"2018-12-03 16:01:56","post_date_gmt":"2018-12-03 15:01:56","post_content":"","post_title":"Am J Clin Nutr.","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"am-j-clin-nutr","to_ping":"","pinged":"","post_modified":"2018-12-03 16:01:56","post_modified_gmt":"2018-12-03 15:01:56","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/am-j-clin-nutr\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Gstt1 genotype modifies the association between cruciferous vegetable intake and the risk of myocardial infarction. - Aprifel<\/title>\n<meta name=\"description\" content=\"Gstt1 genotype modifies the association between cruciferous vegetable intake and the risk of myocardial infarction. - Aprifel\" \/>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Gstt1 genotype modifies the association between cruciferous vegetable intake and the risk of myocardial infarction.\" \/>\n<meta property=\"og:description\" content=\"Gstt1 genotype modifies the association between cruciferous vegetable intake and the risk of myocardial infarction.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/gstt1-genotype-modifies-the-association-between-cruciferous\/\" \/>\n<meta property=\"og:site_name\" content=\"Aprifel\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/gstt1-genotype-modifies-the-association-between-cruciferous\/\",\"url\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/gstt1-genotype-modifies-the-association-between-cruciferous\/\",\"name\":\"Gstt1 genotype modifies the association between cruciferous vegetable intake and the risk of myocardial infarction. - Aprifel\",\"isPartOf\":{\"@id\":\"https:\/\/www.aprifel.com\/fr\/#website\"},\"datePublished\":\"2018-12-04T02:33:30+00:00\",\"dateModified\":\"2018-12-04T02:33:30+00:00\",\"description\":\"Gstt1 genotype modifies the association between cruciferous vegetable intake and the risk of myocardial infarction. - Aprifel\",\"breadcrumb\":{\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/gstt1-genotype-modifies-the-association-between-cruciferous\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/gstt1-genotype-modifies-the-association-between-cruciferous\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/gstt1-genotype-modifies-the-association-between-cruciferous\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/www.aprifel.com\/fr\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"R\u00e9sum\u00e9s\",\"item\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Gstt1 genotype modifies the association between cruciferous vegetable intake and the risk of myocardial infarction.\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.aprifel.com\/fr\/#website\",\"url\":\"https:\/\/www.aprifel.com\/fr\/\",\"name\":\"Aprifel\",\"description\":\"Agence pour la Recherche et l\u2019Information en Fruits et L\u00e9gumes\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.aprifel.com\/fr\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Gstt1 genotype modifies the association between cruciferous vegetable intake and the risk of myocardial infarction. - Aprifel","description":"Gstt1 genotype modifies the association between cruciferous vegetable intake and the risk of myocardial infarction. - Aprifel","robots":{"index":"noindex","follow":"follow"},"og_locale":"fr_FR","og_type":"article","og_title":"Gstt1 genotype modifies the association between cruciferous vegetable intake and the risk of myocardial infarction.","og_description":"Gstt1 genotype modifies the association between cruciferous vegetable intake and the risk of myocardial infarction.","og_url":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/gstt1-genotype-modifies-the-association-between-cruciferous\/","og_site_name":"Aprifel","twitter_card":"summary_large_image","twitter_misc":{"Dur\u00e9e de lecture estim\u00e9e":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/gstt1-genotype-modifies-the-association-between-cruciferous\/","url":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/gstt1-genotype-modifies-the-association-between-cruciferous\/","name":"Gstt1 genotype modifies the association between cruciferous vegetable intake and the risk of myocardial infarction. - Aprifel","isPartOf":{"@id":"https:\/\/www.aprifel.com\/fr\/#website"},"datePublished":"2018-12-04T02:33:30+00:00","dateModified":"2018-12-04T02:33:30+00:00","description":"Gstt1 genotype modifies the association between cruciferous vegetable intake and the risk of myocardial infarction. - Aprifel","breadcrumb":{"@id":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/gstt1-genotype-modifies-the-association-between-cruciferous\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/gstt1-genotype-modifies-the-association-between-cruciferous\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/gstt1-genotype-modifies-the-association-between-cruciferous\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/www.aprifel.com\/fr\/"},{"@type":"ListItem","position":2,"name":"R\u00e9sum\u00e9s","item":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/"},{"@type":"ListItem","position":3,"name":"Gstt1 genotype modifies the association between cruciferous vegetable intake and the risk of myocardial infarction."}]},{"@type":"WebSite","@id":"https:\/\/www.aprifel.com\/fr\/#website","url":"https:\/\/www.aprifel.com\/fr\/","name":"Aprifel","description":"Agence pour la Recherche et l\u2019Information en Fruits et L\u00e9gumes","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.aprifel.com\/fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"}]}},"_links":{"self":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/resume\/44896"}],"collection":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/resume"}],"about":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/types\/resume"}],"wp:attachment":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/media?parent=44896"}],"wp:term":[{"taxonomy":"mots_cles","embeddable":true,"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/mots_cles?post=44896"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}