{"id":44660,"date":"2008-03-01T00:00:00","date_gmt":"2018-12-04T02:30:00","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/cruciferous-vegetables-the-gstp1-ile105val-genetic-polymorphism\/"},"modified":"2018-12-04T03:30:00","modified_gmt":"2018-12-04T02:30:00","slug":"cruciferous-vegetables-the-gstp1-ile105val-genetic-polymorphism","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/cruciferous-vegetables-the-gstp1-ile105val-genetic-polymorphism\/","title":{"rendered":"Cruciferous vegetables, the gstp1 ile105val genetic polymorphism, and breast cancer risk."},"content":{"rendered":"<p>BACKGROUND: Cruciferous vegetables are the primary source of isothiocyanates and other glucosinolate derivatives that are known to induce phase II detoxifying enzymes, including glutathione S-transferases (GSTs). OBJECTIVE: We investigated the independent and combined effects of cruciferous vegetable intake and the GSTP1 Ile(105)Val genetic polymorphism on breast cancer risk. DESIGN: Analyses included 3035 cases and 3037 population controls who were participating in the Shanghai Breast Cancer Study and for whom diet and genetic data were complete (87% of cases and 85% of controls). RESULTS: With the use of multivariate logistic regression, the GSTP1 Val\/Val genotype was significantly associated with greater breast cancer risk (OR = 1.50; 95% CI: 1.12, 1.99). The association was significantly greater in premenopausal women (OR = 1.69; 95% CI: 1.17, 2.43) than in postmenopausal women (OR = 1.20; 95% CI: 0.74, 1.92). Total cruciferous vegetable intake was not significantly associated with breast cancer risk, although subjects reporting greater turnip (P for trend &lt; 0.001) and Chinese cabbage (P for trend = 0.049) intakes had a significantly lower postmenopausal breast cancer risk. Women with the GSTP1 Val\/Val genotype and low cruciferous vegetable intake had a breast cancer risk 1.74-fold (95% CI: 1.13, 2.67) that of women with the Ile\/Ile or Ile\/Val genotype. This effect of low cruciferous vegetable intake and the Val\/Val genotype was seen predominantly among premenopausal women (OR = 2.08; 95% CI = 1.20, 3.59). CONCLUSIONS: Cruciferous vegetable intake consistent with high isothiocyanate exposure may reduce breast cancer risk. Cruciferous vegetable intake also may ameliorate the effects of the GSTP1 genotype.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-44660","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA.","annee":"2008","mois":"3","numero":"87:3","page":"753-60","auteurs":[{"ID":16490,"post_author":"0","post_date":"2018-12-03 19:39:38","post_date_gmt":"2018-12-03 18:39:38","post_content":"","post_title":"Yu-tang Gao","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"yu-tang-gao","to_ping":"","pinged":"","post_modified":"2018-12-03 19:39:38","post_modified_gmt":"2018-12-03 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Shu","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"xiao-ou-shu","to_ping":"","pinged":"","post_modified":"2018-12-03 16:02:35","post_modified_gmt":"2018-12-03 15:02:35","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/xiao-ou-shu\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":1795,"post_author":"0","post_date":"2018-12-03 16:02:39","post_date_gmt":"2018-12-03 15:02:39","post_content":"","post_title":"Qiuyin Cai","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"qiuyin-cai","to_ping":"","pinged":"","post_modified":"2018-12-03 16:02:39","post_modified_gmt":"2018-12-03 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02:29:59","post_content":"","post_title":"Fowke","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"fowke","to_ping":"","pinged":"","post_modified":"2018-12-04 03:29:59","post_modified_gmt":"2018-12-04 02:29:59","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/fowke\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":44344,"post_author":"0","post_date":"2018-12-04 03:22:24","post_date_gmt":"2018-12-04 02:22:24","post_content":"","post_title":"Lee","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"lee-11","to_ping":"","pinged":"","post_modified":"2018-12-04 03:22:24","post_modified_gmt":"2018-12-04 02:22:24","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/lee-11\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":38751,"post_author":"0","post_date":"2018-12-04 01:42:33","post_date_gmt":"2018-12-04 00:42:33","post_content":"","post_title":"Blum","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"blum","to_ping":"","pinged":"","post_modified":"2018-12-04 01:42:33","post_modified_gmt":"2018-12-04 00:42:33","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/blum\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":42210,"post_author":"0","post_date":"2018-12-04 02:45:31","post_date_gmt":"2018-12-04 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