BACKGROUND: Low-carbohydrate weight-loss diets remain popular; however, the long-term effects of these diets are not known. OBJECTIVE: The objective was to examine the association between low-carbohydrate-diet score and risk of type 2 diabetes DESIGN: We prospectively examined the association between low-carbohydrate-diet score (based on percentage of energy as carbohydrate, fat, and protein) and risk of diabetes among 85 059 women in the Nurses’ Health Study. RESULTS: During 20 y of follow-up, we documented 4670 cases of type 2 diabetes. The multivariate relative risk (RR) of diabetes, after adjustment for body mass index and other covariates, in a comparison of the highest decile of low-carbohydrate-diet score with the lowest was 0.90 (95% CI: 0.78, 1.04; P for trend = 0.26). The multivariate RR for the comparison of extreme deciles of low-carbohydrate-diet score based on total carbohydrate, animal protein, and animal fat was 0.99 (95% CI: 0.85, 1.16; P for trend = 1.0), whereas the RR for a low-carbohydrate-diet score based on total carbohydrate, vegetable protein, and vegetable fat was 0.82 (95% CI: 0.71, 0.94; P for trend = 0.001). A higher dietary glycemic load was strongly associated with an increased risk of diabetes in a comparison of extreme deciles (RR: 2.47; 95% CI: 1.75, 3.47; P for trend < 0.0001)). A higher carbohydrate consumption was also associated with an increased risk of diabetes in a comparison of extreme deciles (RR: 1.26; 95% CI: 1.07, 1.49; P for trend = 0.003). CONCLUSION: These data suggest that diets lower in carbohydrate and higher in fat and protein do not increase the risk of type 2 diabetes in women. In fact, diets rich in vegetable sources of fat and protein may modestly reduce the risk of diabetes<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-43951","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Department of Nutrition, Harvard School of Public Health, Boston, MA 02215, USA.","annee":"2008","mois":"2","numero":"87:2","page":"339-46","auteurs":[{"ID":1718,"post_author":"0","post_date":"2018-12-03 16:01:55","post_date_gmt":"2018-12-03 15:01:55","post_content":"","post_title":"Frank B Hu","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"frank-b-hu","to_ping":"","pinged":"","post_modified":"2018-12-03 16:01:55","post_modified_gmt":"2018-12-03 15:01:55","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/frank-b-hu\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":4220,"post_author":"0","post_date":"2018-12-03 17:13:34","post_date_gmt":"2018-12-03 16:13:34","post_content":"","post_title":"Joann E Manson","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"joann-e-manson","to_ping":"","pinged":"","post_modified":"2018-12-03 17:13:34","post_modified_gmt":"2018-12-03 16:13:34","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/joann-e-manson\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":39970,"post_author":"0","post_date":"2018-12-04 02:06:35","post_date_gmt":"2018-12-04 01:06:35","post_content":"","post_title":"Monbaliu","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"monbaliu","to_ping":"","pinged":"","post_modified":"2018-12-04 02:06:35","post_modified_gmt":"2018-12-04 01:06:35","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/monbaliu\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":43950,"post_author":"0","post_date":"2018-12-04 03:15:10","post_date_gmt":"2018-12-04 02:15:10","post_content":"","post_title":"Halton","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"halton","to_ping":"","pinged":"","post_modified":"2018-12-04 03:15:10","post_modified_gmt":"2018-12-04 02:15:10","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/halton\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":1720,"post_author":"0","post_date":"2018-12-03 16:01:56","post_date_gmt":"2018-12-03 15:01:56","post_content":"","post_title":"Am J Clin Nutr.","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"am-j-clin-nutr","to_ping":"","pinged":"","post_modified":"2018-12-03 16:01:56","post_modified_gmt":"2018-12-03 15:01:56","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/am-j-clin-nutr\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"\n