{"id":41884,"date":"2010-04-01T00:00:00","date_gmt":"2018-12-04T01:40:02","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/dna-damage-and-repair-fruit-and-vegetable-effects-in-a-feeding\/"},"modified":"2018-12-04T02:40:02","modified_gmt":"2018-12-04T01:40:02","slug":"dna-damage-and-repair-fruit-and-vegetable-effects-in-a-feeding","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/dna-damage-and-repair-fruit-and-vegetable-effects-in-a-feeding\/","title":{"rendered":"Dna damage and repair: fruit and vegetable effects in a feeding trial."},"content":{"rendered":"

Abstract
\nEpidemiologic studies have examined the association between fruit and vegetable (F&V) consumption and the risk of cancer. Several cancer-preventive mechanisms have been proposed, such as antioxidant properties and modulation of biotransformation enzyme activities; both may be associated with reducing DNA damage and hence the mutation rate. We investigated, in a randomized, controlled, crossover feeding trial, the effect of 10 servings\/day of botanically defined F&V for 2 wk on endogenous DNA damage; resistance to gamma -irradiation damage; and DNA repair capacity in lymphocytes, measured by the Comet assay. We also explored the association between the UGT1A1*28 polymorphism and serum bilirubin concentrations and DNA damage and repair measures. Healthy men (n = 11) and women (n = 17), age 20 to 40 yr, provided blood samples at the end of each feeding period. Overall, F&V did not affect DNA damage and repair measures in lymphocytes. The number of UGT1A1*28 alleles was inversely associated with sensitivity to gamma -irradiation exposure and DNA repair capacity, but a biological mechanism to explain this association is unclear. A larger sample size is needed to investigate the association between bilirubin concentrations and endogenous DNA damage. With inconsistent findings in the literature, additional dietary intervention studies on the effect of F&V on DNA damage and repair are needed.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-41884","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"University of Washington, Seattle, Washington, USA.","annee":"2010","mois":"4","numero":"62:3","page":"329-35","auteurs":[{"ID":41882,"post_author":"0","post_date":"2018-12-04 02:40:01","post_date_gmt":"2018-12-04 01:40:01","post_content":"","post_title":"Gang Chen","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"gang-chen","to_ping":"","pinged":"","post_modified":"2018-12-04 02:40:01","post_modified_gmt":"2018-12-04 01:40:01","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/gang-chen\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":41883,"post_author":"0","post_date":"2018-12-04 02:40:02","post_date_gmt":"2018-12-04 01:40:02","post_content":"","post_title":"Chang","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"chang-3","to_ping":"","pinged":"","post_modified":"2018-12-04 02:40:02","post_modified_gmt":"2018-12-04 01:40:02","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/chang-3\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":8837,"post_author":"0","post_date":"2018-12-03 18:04:31","post_date_gmt":"2018-12-03 17:04:31","post_content":"","post_title":"Cornelia M Ulrich","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"cornelia-m-ulrich","to_ping":"","pinged":"","post_modified":"2018-12-03 18:04:31","post_modified_gmt":"2018-12-03 17:04:31","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/cornelia-m-ulrich\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":27976,"post_author":"0","post_date":"2018-12-03 23:00:30","post_date_gmt":"2018-12-03 22:00:30","post_content":"","post_title":"NUTR CANCER","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"nutr-cancer","to_ping":"","pinged":"","post_modified":"2018-12-03 23:00:30","post_modified_gmt":"2018-12-03 22:00:30","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/nutr-cancer\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"\nDna damage and repair: fruit and vegetable effects in a feeding trial. - Aprifel<\/title>\n<meta name=\"description\" content=\"Dna damage and repair: fruit and vegetable effects in a feeding trial. - Aprifel\" \/>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Dna damage and repair: fruit and vegetable effects in a feeding trial.\" \/>\n<meta property=\"og:description\" content=\"Dna damage and repair: fruit and vegetable effects in a feeding trial.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/dna-damage-and-repair-fruit-and-vegetable-effects-in-a-feeding\/\" \/>\n<meta property=\"og:site_name\" content=\"Aprifel\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/dna-damage-and-repair-fruit-and-vegetable-effects-in-a-feeding\/\",\"url\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/dna-damage-and-repair-fruit-and-vegetable-effects-in-a-feeding\/\",\"name\":\"Dna damage and repair: fruit and vegetable effects in a feeding trial. - Aprifel\",\"isPartOf\":{\"@id\":\"https:\/\/www.aprifel.com\/fr\/#website\"},\"datePublished\":\"2018-12-04T01:40:02+00:00\",\"dateModified\":\"2018-12-04T01:40:02+00:00\",\"description\":\"Dna damage and repair: fruit and vegetable effects in a feeding trial. - Aprifel\",\"breadcrumb\":{\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/dna-damage-and-repair-fruit-and-vegetable-effects-in-a-feeding\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/dna-damage-and-repair-fruit-and-vegetable-effects-in-a-feeding\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/dna-damage-and-repair-fruit-and-vegetable-effects-in-a-feeding\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/www.aprifel.com\/fr\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"R\u00e9sum\u00e9s\",\"item\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Dna damage and repair: fruit and vegetable effects in a feeding trial.\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.aprifel.com\/fr\/#website\",\"url\":\"https:\/\/www.aprifel.com\/fr\/\",\"name\":\"Aprifel\",\"description\":\"Agence pour la Recherche et l\u2019Information en Fruits et L\u00e9gumes\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.aprifel.com\/fr\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Dna damage and repair: fruit and vegetable effects in a feeding trial. - Aprifel","description":"Dna damage and repair: fruit and vegetable effects in a feeding trial. - Aprifel","robots":{"index":"noindex","follow":"follow"},"og_locale":"fr_FR","og_type":"article","og_title":"Dna damage and repair: fruit and vegetable effects in a feeding trial.","og_description":"Dna damage and repair: fruit and vegetable effects in a feeding trial.","og_url":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/dna-damage-and-repair-fruit-and-vegetable-effects-in-a-feeding\/","og_site_name":"Aprifel","twitter_card":"summary_large_image","twitter_misc":{"Dur\u00e9e de lecture estim\u00e9e":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/dna-damage-and-repair-fruit-and-vegetable-effects-in-a-feeding\/","url":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/dna-damage-and-repair-fruit-and-vegetable-effects-in-a-feeding\/","name":"Dna damage and repair: fruit and vegetable effects in a feeding trial. - Aprifel","isPartOf":{"@id":"https:\/\/www.aprifel.com\/fr\/#website"},"datePublished":"2018-12-04T01:40:02+00:00","dateModified":"2018-12-04T01:40:02+00:00","description":"Dna damage and repair: fruit and vegetable effects in a feeding trial. - Aprifel","breadcrumb":{"@id":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/dna-damage-and-repair-fruit-and-vegetable-effects-in-a-feeding\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/dna-damage-and-repair-fruit-and-vegetable-effects-in-a-feeding\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/dna-damage-and-repair-fruit-and-vegetable-effects-in-a-feeding\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/www.aprifel.com\/fr\/"},{"@type":"ListItem","position":2,"name":"R\u00e9sum\u00e9s","item":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/"},{"@type":"ListItem","position":3,"name":"Dna damage and repair: fruit and vegetable effects in a feeding trial."}]},{"@type":"WebSite","@id":"https:\/\/www.aprifel.com\/fr\/#website","url":"https:\/\/www.aprifel.com\/fr\/","name":"Aprifel","description":"Agence pour la Recherche et l\u2019Information en Fruits et L\u00e9gumes","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.aprifel.com\/fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"}]}},"_links":{"self":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/resume\/41884"}],"collection":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/resume"}],"about":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/types\/resume"}],"wp:attachment":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/media?parent=41884"}],"wp:term":[{"taxonomy":"mots_cles","embeddable":true,"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/mots_cles?post=41884"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}