{"id":41680,"date":"2009-08-01T00:00:00","date_gmt":"2018-12-04T01:36:42","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/adherence-to-a-mediterranean-diet-cognitive-decline-and\/"},"modified":"2018-12-04T02:36:42","modified_gmt":"2018-12-04T01:36:42","slug":"adherence-to-a-mediterranean-diet-cognitive-decline-and","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/adherence-to-a-mediterranean-diet-cognitive-decline-and\/","title":{"rendered":"Adherence to a Mediterranean diet, cognitive decline, and risk of dementia."},"content":{"rendered":"<p style=\"text-align: justify\"><strong>CONTEXT:<\/strong><br \/>\nHigher adherence to a Mediterranean-type diet is linked to lower risk for mortality and chronic diseases, but its association with cognitive decline is unclear.<\/p>\n<p style=\"text-align: justify\"><strong>OBJECTIVE:<\/strong><br \/>\nTo investigate the association of a Mediterranean diet with change in cognitive performance and risk for dementia in elderly French persons.<\/p>\n<p style=\"text-align: justify\"><strong>DESIGN, SETTING, AND PARTICIPANTS:<\/strong><br \/>\nProspective cohort study of 1410 adults (&gt; or = 65 years) from Bordeaux, France, included in the Three-City cohort in 2001-2002 and reexamined at least once over 5 years. Adherence to a Mediterranean diet (scored as 0 to 9) was computed from a food frequency questionnaire and 24-hour recall.<\/p>\n<p style=\"text-align: justify\"><strong>MAIN OUTCOME MEASURES:<\/strong><br \/>\nCognitive performance was assessed on 4 neuropsychological tests: the Mini-Mental State Examination (MMSE), Isaacs Set Test (IST), Benton Visual Retention Test (BVRT), and Free and Cued Selective Reminding Test (FCSRT). Incident cases of dementia (n = 99) were validated by an independent expert committee of neurologists.<\/p>\n<p style=\"text-align: justify\"><strong>RESULTS:<\/strong><br \/>\nAdjusting for age, sex, education, marital status, energy intake, physical activity, depressive symptomatology, taking 5 medications\/d or more, apolipoprotein E genotype, cardiovascular risk factors, and stroke, higher Mediterranean diet score was associated with fewer MMSE errors (beta = -0.006; 95% confidence interval [CI], -0.01 to -0.0003; P = .04 for 1 point of the Mediterranean diet score). Performance on the IST, BVRT, or FCSRT over time was not significantly associated with Mediterranean diet adherence. Greater adherence as a categorical variable (score 6-9) was not significantly associated with fewer MMSE errors and better FCSRT scores in the entire cohort, but among individuals who remained free from dementia over 5 years, the association for the highest compared with the lowest group was significant (adjusted for all factors, for MMSE: beta = -0.03; 95% CI, -0.05 to -0.001; P = .04; for FCSRT: beta = 0.21; 95% CI, 0.008 to 0.41; P =.04). Mediterranean diet adherence was not associated with the risk for incident dementia (fully adjusted model: hazard ratio, 1.12; 95% CI, 0.60 to 2.10; P = .72), although power to detect a difference was limited.<\/p>\n<p style=\"text-align: justify\"><strong>CONCLUSIONS:<\/strong><br \/>\nHigher adherence to a Mediterranean diet was associated with slower MMSE cognitive decline but not consistently with other cognitive tests. Higher adherence was not associated with risk for incident dementia.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-41680","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Research Center INSERM U897, Universit\u00e9 Victor Segalen Bordeaux 2, Bordeaux, France. catherine.feart@isped.u-bordeaux2.fr\r\n\r\nErratum in:\r\n\r\nJAMA. 2009 Dec 9;302(22):2436. \r\n\r\nComment in:\r\n\r\nJAMA. 2009 Aug 12;302(6):686-7. \r\nJAMA. 2009 Dec 9;302(22):2433-4. \r\nPrev Cardiol. 2010 Spring;13(2):94-6. \r\nJAMA. 2009 Dec 9;302(22):2432; author reply 2432. \r\n\r\n","annee":"2009","mois":"8","numero":"302:6","page":"638-648","auteurs":[{"ID":2277,"post_author":"0","post_date":"2018-12-03 16:54:02","post_date_gmt":"2018-12-03 15:54:02","post_content":"","post_title":"Nikolaos 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Barberger-Gateau","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"pascale-barberger-gateau","to_ping":"","pinged":"","post_modified":"2018-12-03 21:20:25","post_modified_gmt":"2018-12-03 20:20:25","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/pascale-barberger-gateau\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":2181,"post_author":"0","post_date":"2018-12-03 16:53:09","post_date_gmt":"2018-12-03 15:53:09","post_content":"","post_title":"C\u00e9cilia Samieri","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"cecilia-samieri","to_ping":"","pinged":"","post_modified":"2018-12-03 16:53:09","post_modified_gmt":"2018-12-03 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