{"id":41168,"date":"2010-04-01T00:00:00","date_gmt":"2018-12-04T01:28:07","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/low-fat-dietary-pattern-and-lipoprotein-risk-factors-the\/"},"modified":"2018-12-04T02:28:07","modified_gmt":"2018-12-04T01:28:07","slug":"low-fat-dietary-pattern-and-lipoprotein-risk-factors-the","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/low-fat-dietary-pattern-and-lipoprotein-risk-factors-the\/","title":{"rendered":"Low-fat dietary pattern and lipoprotein risk factors: the women&rsquo;s health initiative dietary modification trial."},"content":{"rendered":"<p>Am J Clin Nutr. 2010 Apr;91(4):860-74. Epub 2010 Feb 17.<\/p>\n<p>Abstract<br \/>\nBACKGROUND: The Women&rsquo;s Health Initiative Dietary Modification Trial tested the effects on chronic disease of a dietary pattern lower in fat and higher in vegetables, fruit, and grains. OBJECTIVE: The objective was to evaluate the effects of dietary carbohydrate changes on lipids and lipoprotein composition. DESIGN: Postmenopausal women were randomly assigned to an intervention or a comparison group for a mean of 8.1 y. Lipoprotein analyses and subclasses were based on subsamples of 2730 and 209 participants, respectively. RESULTS: At year 6, the total reported fat intake was 7.8% lower and carbohydrate intake was 7.6% higher in the intervention group than in the comparison group. Triglyceride change between groups differed by 2.3, 3.8, and -0.8 mg\/dL at 1, 3, and 6 y, respectively, and HDL-cholesterol change differed by -1.6, -0.7, and -1.0 mg\/dL at 1, 3, and 6 y, respectively. Changes did not differ by age, ethnicity, or obesity. In diabetic intervention women who were white, the triglyceride difference between the intervention and comparison groups was 33.8 mg\/dL, whereas in black women with diabetes (n = 50 in the intervention group; n = 83 in the comparison group), the triglyceride difference was 6.4 mg\/dL (P for 3-factor interaction = 0.049). No significant changes were observed in apolipoprotein or lipoprotein particles. Reductions in LDL cholesterol varied by quartile of reported lowering of saturated or trans fat. CONCLUSIONS: The replacement of 7-8% of fat intake with complex carbohydrates over 6 y was not associated with clinically adverse effects on triglycerides, HDL cholesterol, or lipoprotein subclasses. Diabetic white women with higher triglyceride concentrations may have greater increases in triglycerides.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-41168","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"MedStar Research Institute, Hyattsville, MD 20782, USA. barbara.v.howard@medstar.net\r\n\r\nComment in:\r\n\r\nAm J Clin Nutr. 2010 Apr;91(4):829-30. \r\n\r\n","annee":"2010","mois":"4","numero":"91:4","page":"860-74","auteurs":[{"ID":30573,"post_author":"0","post_date":"2018-12-03 23:33:43","post_date_gmt":"2018-12-03 22:33:43","post_content":"","post_title":"Charles B Eaton","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"charles-b-eaton","to_ping":"","pinged":"","post_modified":"2018-12-03 23:33:43","post_modified_gmt":"2018-12-03 22:33:43","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/charles-b-eaton\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":14754,"post_author":"0","post_date":"2018-12-03 19:13:32","post_date_gmt":"2018-12-03 18:13:32","post_content":"","post_title":"Barbara V Howard","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"barbara-v-howard","to_ping":"","pinged":"","post_modified":"2018-12-03 19:13:32","post_modified_gmt":"2018-12-03 18:13:32","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/barbara-v-howard\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":41167,"post_author":"0","post_date":"2018-12-04 02:28:06","post_date_gmt":"2018-12-04 01:28:06","post_content":"","post_title":"Curb","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"curb","to_ping":"","pinged":"","post_modified":"2018-12-04 02:28:06","post_modified_gmt":"2018-12-04 01:28:06","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/curb\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":1720,"post_author":"0","post_date":"2018-12-03 16:01:56","post_date_gmt":"2018-12-03 15:01:56","post_content":"","post_title":"Am J Clin Nutr.","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"am-j-clin-nutr","to_ping":"","pinged":"","post_modified":"2018-12-03 16:01:56","post_modified_gmt":"2018-12-03 15:01:56","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/am-j-clin-nutr\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - 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