{"id":38554,"date":"2011-09-01T00:00:00","date_gmt":"2018-12-04T00:39:16","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/a-mediterranean-style-low-glycemic-load-diet-reduces-the\/"},"modified":"2018-12-04T01:39:16","modified_gmt":"2018-12-04T00:39:16","slug":"a-mediterranean-style-low-glycemic-load-diet-reduces-the","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/a-mediterranean-style-low-glycemic-load-diet-reduces-the\/","title":{"rendered":"A mediterranean-style, low-glycemic-load diet reduces the expression of 3-hydroxy-3-methylglutaryl-coenzyme a reductase in mononuclear cells and plasma insulin in women with metabolic syndrome"},"content":{"rendered":"<p style=\"text-align: justify\">We evaluated changes in low-density lipoprotein (LDL) receptor and 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase gene expression in women with metabolic syndrome and elevated plasma LDL cholesterol (LDL-C). We hypothesized that expression of these 2 genes would be modulated by our dietary intervention. Twenty-five women were instructed to follow a Mediterranean-style low-glycemic-load diet for 12 weeks. Quantitative real-time polymerase chain reaction was used to measure messenger RNA (mRNA) abundance of the LDL receptor and HMG-CoA reductase in mononuclear cells, which were used as a proxy of liver expression of these 2 genes. All women experienced favorable impacts on metabolic syndrome variables, with decreases in waist circumference (P &lt; .001), plasma triglycerides (P &lt; .05), and systolic blood pressure (P &lt; .05) compared with baseline. Furthermore, participants had reductions in LDL-C (P &lt; .01), plasma insulin (P &lt; .001), and homeostatic model assessment score for insulin resistance (P &lt; .001) over time. In addition, significant decreases were found in plasma tumor necrosis factor &alpha; (P &lt; .01), which might have contributed to the improvements observed in insulin resistance. Although no changes in LDL-receptor mRNA levels were observed, HMG-CoA-reductase gene expression was reduced (P &lt; .001) after 12 weeks. The reductions in plasma insulin correlated with changes in HMG-CoA-reductase mRNA levels (r = 0.45, P &lt; .01). In conclusion, the observed reductions in plasma insulin may have affected the expression of a key regulatory gene of cholesterol synthesis, HMG-CoA reductase. The decreased HMG-CoA-reductase expression may be related to lower secretion of very low density lipoprotein (VLDL)-cholesterol, which, in turn, would account for the reductions in LDL-C.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-38554","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA","annee":"2011","mois":"9","numero":"31:9","page":"659-64","auteurs":[{"ID":22788,"post_author":"0","post_date":"2018-12-03 21:11:39","post_date_gmt":"2018-12-03 20:11:39","post_content":"","post_title":"Jaehoon Lee","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"jaehoon-lee","to_ping":"","pinged":"","post_modified":"2018-12-03 21:11:39","post_modified_gmt":"2018-12-03 20:11:39","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/jaehoon-lee\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3240,"post_author":"0","post_date":"2018-12-03 17:03:38","post_date_gmt":"2018-12-03 16:03:38","post_content":"","post_title":"Yikyung Park","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"yikyung-park","to_ping":"","pinged":"","post_modified":"2018-12-03 17:03:38","post_modified_gmt":"2018-12-03 16:03:38","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/yikyung-park\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":11621,"post_author":"0","post_date":"2018-12-03 18:37:24","post_date_gmt":"2018-12-03 17:37:24","post_content":"","post_title":"Jessica L Jones","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"jessica-l-jones","to_ping":"","pinged":"","post_modified":"2018-12-03 18:37:24","post_modified_gmt":"2018-12-03 17:37:24","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/jessica-l-jones\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":31528,"post_author":"0","post_date":"2018-12-03 23:46:21","post_date_gmt":"2018-12-03 22:46:21","post_content":"","post_title":"NUTR RES","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"nutr-res","to_ping":"","pinged":"","post_modified":"2018-12-03 23:46:21","post_modified_gmt":"2018-12-03 22:46:21","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/nutr-res\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - 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