{"id":38481,"date":"2011-11-01T00:00:00","date_gmt":"2018-12-04T00:38:03","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/effects-of-a-2-y-dietary-weight-loss-intervention-on-cholesterol\/"},"modified":"2018-12-04T01:38:03","modified_gmt":"2018-12-04T00:38:03","slug":"effects-of-a-2-y-dietary-weight-loss-intervention-on-cholesterol","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/effects-of-a-2-y-dietary-weight-loss-intervention-on-cholesterol\/","title":{"rendered":"Effects of a 2-y dietary weight-loss intervention on cholesterol metabolism in moderately obese men."},"content":{"rendered":"<p>BACKGROUND: <\/p>\n<p>Long-term dietary weight loss results in complex metabolic changes. However, its effect on cholesterol metabolism in obese subjects is still unclear.<\/p>\n<p>OBJECTIVE: <\/p>\n<p>We assessed the effects of 2 y of weight loss achieved with various diet regimens on phytosterols (markers of intestinal cholesterol absorption), lanosterol (marker of de novo cholesterol synthesis), and changes in apolipoprotein concentrations.<\/p>\n<p>DESIGN: <\/p>\n<p>We conducted the 2-y Dietary Intervention Randomized Controlled Trial (DIRECT-a study of low-fat, Mediterranean, and low-carbohydrate diets). We assessed circulating phytosterol and lanosterol concentrations and their ratios to cholesterol and apolipoproteins A-I and B-100 in 90 DIRECT participants at 0, 6, and 24 mo.<\/p>\n<p>RESULTS: <\/p>\n<p>We observed a significant upregulation of the markers of cholesterol absorption (campesterol: +16.8%, P &lt; 0.001) and a downregulation of the markers of cholesterol synthesis (lanosterol: -16.5%, P = 0.008) during the active weight-loss phase (first 6 mo, weight loss of 5%, 6%, and 10% in the 3 diet groups, respectively), followed by a rebound (campesterol: -6.2%, P = 0.045; lanosterol: +43.7%, P &lt; 0.001) during the next 18 mo (weight gain of 1%, 1%, and 2% in the 3 diet groups, respectively). HDL cholesterol continuously increased during the study (17.0%, P &lt; 0.001), whereas LDL cholesterol remained constant. At the end of the 24-mo follow-up period, campesterol (P &lt; 0.001) and lanosterol (P = 0.016) amounts were significantly higher than baseline values. The concentration of apolipoprotein B-100 correlated with cholesterol metabolism (&#961; = 0.299 and P = 0.020 for lanosterol; &#961; = -0.105 and NS for campesterol), and the homeostasis model assessment of insulin resistance correlated with lanosterol (&#961; = 0.09, P = 0.001).<\/p>\n<p>CONCLUSIONS: <\/p>\n<p>Long-term weight loss is related to a characteristic response suggestive of altered cholesterol and apolipoprotein metabolism. Various diets have a similar effect on these effects.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-38481","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"University Institute of Clinical Chemistry, Inselspital - Bern University Hospital, Switzerland.","annee":"2011","mois":"11","numero":"94:5","page":"118995-","auteurs":[{"ID":38478,"post_author":"0","post_date":"2018-12-04 01:38:01","post_date_gmt":"2018-12-04 00:38:01","post_content":"","post_title":"U Ceglarek","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"u-ceglarek","to_ping":"","pinged":"","post_modified":"2018-12-04 01:38:01","post_modified_gmt":"2018-12-04 00:38:01","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/u-ceglarek\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":38479,"post_author":"0","post_date":"2018-12-04 01:38:02","post_date_gmt":"2018-12-04 00:38:02","post_content":"","post_title":"Leichtle","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"leichtle","to_ping":"","pinged":"","post_modified":"2018-12-04 01:38:02","post_modified_gmt":"2018-12-04 00:38:02","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/leichtle\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":38480,"post_author":"0","post_date":"2018-12-04 01:38:02","post_date_gmt":"2018-12-04 00:38:02","post_content":"","post_title":"Helmschrodt","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"helmschrodt","to_ping":"","pinged":"","post_modified":"2018-12-04 01:38:02","post_modified_gmt":"2018-12-04 00:38:02","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/helmschrodt\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":1720,"post_author":"0","post_date":"2018-12-03 16:01:56","post_date_gmt":"2018-12-03 15:01:56","post_content":"","post_title":"Am J Clin Nutr.","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"am-j-clin-nutr","to_ping":"","pinged":"","post_modified":"2018-12-03 16:01:56","post_modified_gmt":"2018-12-03 15:01:56","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/am-j-clin-nutr\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - 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