{"id":38012,"date":"2012-05-01T00:00:00","date_gmt":"2018-12-04T00:28:44","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/prediagnostic-circulating-carotenoid-levels-and-the-risk\/"},"modified":"2018-12-04T01:28:44","modified_gmt":"2018-12-04T00:28:44","slug":"prediagnostic-circulating-carotenoid-levels-and-the-risk","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/prediagnostic-circulating-carotenoid-levels-and-the-risk\/","title":{"rendered":"Prediagnostic circulating carotenoid levels and the risk of non-hodgkin lymphoma: the multiethnic cohort"},"content":{"rendered":"

Given the lower risk of non-Hodgkin lymphoma (NHL) associated with a diet rich in fruits and vegetables observed in several, but not all, previous reports, this analysis examined the association of NHL with prediagnostic circulating levels of carotenoids found in these food groups. We conducted a nested case-control within the Multiethnic Cohort with 271 NHL cases and 538 controls matched on sex, ethnicity, location (Hawaii or Los Angeles), birth year, date and time of blood draw, and hours fasting prior to blood draw. Serum carotenoid levels were obtained by high pressure liquid chromatography\/photodiode-array detection. Conditional logistic regression was used to calculate odds ratios (OR) for the risk of NHL according to tertiles of serum carotenoids and trend tests using continuous variables. Higher total serum carotenoids (OR(T3 vs. T1)=0.66 [0.46-0.96]; P(trend)=0.02), lycopene (OR=0.54 [0.38-0.78]; P(trend)=0.003), and α-cryptoxanthin (OR=0.53 [0.36-0.78]; P(trend)=0.003) were associated with a lower risk of NHL. For retinol (OR=0.90 [0.61-1.33]; P(trend)=0.04), a statistically significant inverse linear trend was detected. Risk estimates remained unchanged with adjustment for NHL risk factors and were similar in analyses stratified by sex and ethnicity; heterogeneity with NHL subtype was detected only for β-carotene. Other carotenoids, including α-carotene, β-carotene, lutein, β-cryptoxanthin, and zeaxanthin showed no association with risk. These data provide support for a protective role of carotenoid-rich fruits and vegetables in the etiology of NHL<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-38012","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"University of Hawaii Cancer Center, Honolulu, Hawaii, United States","annee":"2012","mois":"5","numero":"","page":"","auteurs":[{"ID":3177,"post_author":"0","post_date":"2018-12-03 17:03:00","post_date_gmt":"2018-12-03 16:03:00","post_content":"","post_title":"Gertraud Maskarinec","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"gertraud-maskarinec","to_ping":"","pinged":"","post_modified":"2018-12-03 17:03:00","post_modified_gmt":"2018-12-03 16:03:00","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/gertraud-maskarinec\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":38010,"post_author":"0","post_date":"2018-12-04 01:28:43","post_date_gmt":"2018-12-04 00:28:43","post_content":"","post_title":"Conroy","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"conroy","to_ping":"","pinged":"","post_modified":"2018-12-04 01:28:43","post_modified_gmt":"2018-12-04 00:28:43","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/conroy\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":24760,"post_author":"0","post_date":"2018-12-03 22:02:05","post_date_gmt":"2018-12-03 21:02:05","post_content":"","post_title":"N J Ollberding","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"n-j-ollberding","to_ping":"","pinged":"","post_modified":"2018-12-03 22:02:05","post_modified_gmt":"2018-12-03 21:02:05","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/n-j-ollberding\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":38011,"post_author":"0","post_date":"2018-12-04 01:28:44","post_date_gmt":"2018-12-04 00:28:44","post_content":"","post_title":"Blood","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"blood","to_ping":"","pinged":"","post_modified":"2018-12-04 01:28:44","post_modified_gmt":"2018-12-04 00:28:44","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/blood\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"\nPrediagnostic circulating carotenoid levels and the risk of non-hodgkin lymphoma: the multiethnic cohort - 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