{"id":36686,"date":"2012-09-01T00:00:00","date_gmt":"2018-12-04T00:05:12","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/manipulating-antioxidant-intake-in-asthma-a-randomized-controlled\/"},"modified":"2018-12-04T01:05:12","modified_gmt":"2018-12-04T00:05:12","slug":"manipulating-antioxidant-intake-in-asthma-a-randomized-controlled","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/manipulating-antioxidant-intake-in-asthma-a-randomized-controlled\/","title":{"rendered":"Manipulating antioxidant intake in asthma: a randomized controlled trial."},"content":{"rendered":"<p>BACKGROUND: Antioxidant-rich diets are associated with reduced asthma prevalence in epidemiologic studies. We previously showed that short-term manipulation of antioxidant defenses leads to changes in asthma outcomes.<\/p>\n<p>OBJECTIVE: The objective was to investigate the effects of a high-antioxidant diet compared with those of a low-antioxidant diet, with or without lycopene supplementation, in asthma.<\/p>\n<p>DESIGN: Asthmatic adults (n = 137) were randomly assigned to a high-antioxidant diet (5 servings of vegetables and 2 servings of fruit daily; n = 46) or a low-antioxidant diet (&#8804;2 servings of vegetables and 1 serving of fruit daily; n = 91) for 14 d and then commenced a parallel, randomized, controlled supplementation trial. Subjects who consumed the high-antioxidant diet received placebo. Subjects who consumed the low-antioxidant diet received placebo or tomato extract (45 mg lycopene\/d). The intervention continued until week 14 or until an exacerbation occurred.<\/p>\n<p>RESULTS: After 14 d, subjects consuming the low-antioxidant diet had a lower percentage predicted forced expiratory volume in 1 s and percentage predicted forced vital capacity than did those consuming the high-antioxidant diet. Subjects in the low-antioxidant diet group had increased plasma C-reactive protein at week 14. At the end of the trial, time to exacerbation was greater in the high-antioxidant than in the low-antioxidant diet group, and the low-antioxidant diet group was 2.26 (95% CI: 1.04, 4.91; P = 0.039) times as likely to exacerbate. Of the subjects in the low-antioxidant diet group, no difference in airway or systemic inflammation or clinical outcomes was observed between the groups that consumed the tomato extract and those who consumed placebo.<\/p>\n<p>CONCLUSIONS: Modifying the dietary intake of carotenoids alters clinical asthma outcomes. Improvements were evident only after increased fruit and vegetable intake, which suggests that whole-food interventions are most effective. This trial was registered at http:\/\/www.actr.org.au as ACTRN012606000286549.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-36686","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Centre for Asthma and Respiratory Diseases and Clinical Research Design, University of Newcastle, New South Wales, Australia. lisa.wood@newcastle.edu\r\n","annee":"2012","mois":"9","numero":"96:3","page":"534-543","auteurs":[{"ID":4902,"post_author":"0","post_date":"2018-12-03 17:22:08","post_date_gmt":"2018-12-03 16:22:08","post_content":"","post_title":"Lisa G Wood","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"lisa-g-wood","to_ping":"","pinged":"","post_modified":"2018-12-03 17:22:08","post_modified_gmt":"2018-12-03 16:22:08","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/lisa-g-wood\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":29780,"post_author":"0","post_date":"2018-12-03 23:23:36","post_date_gmt":"2018-12-03 22:23:36","post_content":"","post_title":"M L Garg","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"m-l-garg","to_ping":"","pinged":"","post_modified":"2018-12-03 23:23:36","post_modified_gmt":"2018-12-03 22:23:36","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/m-l-garg\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":36685,"post_author":"0","post_date":"2018-12-04 01:05:12","post_date_gmt":"2018-12-04 00:05:12","post_content":"","post_title":"Smart","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"smart","to_ping":"","pinged":"","post_modified":"2018-12-04 01:05:12","post_modified_gmt":"2018-12-04 00:05:12","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/smart\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":1720,"post_author":"0","post_date":"2018-12-03 16:01:56","post_date_gmt":"2018-12-03 15:01:56","post_content":"","post_title":"Am J Clin Nutr.","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"am-j-clin-nutr","to_ping":"","pinged":"","post_modified":"2018-12-03 16:01:56","post_modified_gmt":"2018-12-03 15:01:56","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/am-j-clin-nutr\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - 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