{"id":35343,"date":"2013-02-01T00:00:00","date_gmt":"2018-12-03T23:42:41","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/fruit-and-vegetable-intake-and-risk-of-breast-cancer-by-hormone\/"},"modified":"2018-12-04T00:42:41","modified_gmt":"2018-12-03T23:42:41","slug":"fruit-and-vegetable-intake-and-risk-of-breast-cancer-by-hormone","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/fruit-and-vegetable-intake-and-risk-of-breast-cancer-by-hormone\/","title":{"rendered":"Fruit and vegetable intake and risk of breast cancer by hormone receptor status."},"content":{"rendered":"<p>Background Estrogen receptor-negative (ER(-)) breast cancer has few known or modifiable risk factors. Because ER(-) tumors account for only 15% to 20% of breast cancers, large pooled analyses are necessary to evaluate precisely the suspected inverse association between fruit and vegetable intake and risk of ER(-) breast cancer. Methods Among 993 466 women followed for 11 to 20 years in 20 cohort studies, we documented 19 869 estrogen receptor positive (ER(+)) and 4821 ER(-) breast cancers. We calculated study-specific multivariable relative risks (RRs) and 95% confidence intervals (CIs) using Cox proportional hazards regression analyses and then combined them using a random-effects model. All statistical tests were two-sided. Results Total fruit and vegetable intake was statistically significantly inversely associated with risk of ER(-) breast cancer but not with risk of breast cancer overall or of ER(+) tumors. The inverse association for ER(-) tumors was observed primarily for vegetable consumption. The pooled relative risks comparing the highest vs lowest quintile of total vegetable consumption were 0.82 (95% CI = 0.74 to 0.90) for ER(-) breast cancer and 1.04 (95% CI = 0.97 to 1.11) for ER(+) breast cancer (P (common-effects) by ER status &lt; .001). Total fruit consumption was non-statistically significantly associated with risk of ER(-) breast cancer (pooled multivariable RR comparing the highest vs lowest quintile = 0.94, 95% CI = 0.85 to 1.04). Conclusions We observed no association between total fruit and vegetable intake and risk of overall breast cancer. However, vegetable consumption was inversely associated with risk of ER(-) breast cancer in our large pooled analyses.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-35343","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Longwood Avenue, Boston, MA 02115. pojun@channing.harvard.edu.","annee":"2013","mois":"2","numero":"105:3","page":"219-236","auteurs":[{"ID":32648,"post_author":"0","post_date":"2018-12-04 00:01:52","post_date_gmt":"2018-12-03 23:01:52","post_content":"","post_title":"Sora Jung","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"sora-jung","to_ping":"","pinged":"","post_modified":"2018-12-04 00:01:52","post_modified_gmt":"2018-12-03 23:01:52","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/sora-jung\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":16460,"post_author":"0","post_date":"2018-12-03 19:39:06","post_date_gmt":"2018-12-03 18:39:06","post_content":"","post_title":"Donna Spiegelman","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"donna-spiegelman","to_ping":"","pinged":"","post_modified":"2018-12-03 19:39:06","post_modified_gmt":"2018-12-03 18:39:06","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/donna-spiegelman\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":23100,"post_author":"0","post_date":"2018-12-03 21:18:14","post_date_gmt":"2018-12-03 20:18:14","post_content":"","post_title":"Laura Baglietto","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"laura-baglietto","to_ping":"","pinged":"","post_modified":"2018-12-03 21:18:14","post_modified_gmt":"2018-12-03 20:18:14","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/laura-baglietto\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":35342,"post_author":"0","post_date":"2018-12-04 00:42:41","post_date_gmt":"2018-12-03 23:42:41","post_content":"","post_title":"J NATL CANCER INST","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"j-natl-cancer-inst","to_ping":"","pinged":"","post_modified":"2018-12-04 00:42:41","post_modified_gmt":"2018-12-03 23:42:41","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/j-natl-cancer-inst\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - 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