{"id":34391,"date":"2013-05-01T00:00:00","date_gmt":"2018-12-03T23:28:38","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/low-fat-diet-and-skin-cancer-risk-the-women-s-health-initiative\/"},"modified":"2018-12-04T00:28:38","modified_gmt":"2018-12-03T23:28:38","slug":"low-fat-diet-and-skin-cancer-risk-the-women-s-health-initiative","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/low-fat-diet-and-skin-cancer-risk-the-women-s-health-initiative\/","title":{"rendered":"Low fat diet and skin cancer risk: the women’s health initiative randomized controlled dietary modification trial"},"content":{"rendered":"

Background: Large cohort studies have reported no relationship between dietary fat and nonmelanoma skin cancer (NMSC), although a low-fat diet intervention reduced NMSC risk in a small clinical trial. In animal studies, skin tumor development has been reduced by low-fat diet. We evaluated the effect of a low-fat dietary pattern on NMSC and melanoma in the Women's Health Initiative Dietary Modification trial.<\/p>\n

Methods: Postmenopausal women aged 50 to 79 years (N=48,835) were randomly assigned to the low-fat dietary pattern intervention (N=19,541) or comparison group (N=29,294). The intervention goals included decreasing fat intake to ≤20% of calories, increasing vegetable and fruit intake, and increasing grain intake. Self-reported incident NMSC (N=4,907) and physician-adjudicated incident melanoma (N=279) were ascertained every 6 months.<\/p>\n

Results: Over 8.1 years of follow-up, the low-fat diet intervention did not affect overall incidence of NMSC (hazard ratio [HR] 0.98, 95% confidence interval [CI]: 0.92-1.04) or melanoma (HR 1.04, 95% CI: 0.82-1.32). In subgroup analyses of melanoma risk, baseline fat intake interacted significantly with group assignment (Pinteraction=0.006). Among women with higher baseline fat intake, the dietary intervention significantly increased risk (HR 1.48; 95% CI: 1.06-2.07), whereas, among women with lower baseline fat intake, the intervention tended to reduce melanoma risk (HR 0.72, 95% CI: 0.50-1.02).<\/p>\n

Conclusions: In this large randomized trial, a low-fat dietary pattern did not affect overall incidence of NMSC or melanoma.<\/p>\n

Impact: A low-fat diet does not reduce incidence of NMSC, but an interaction between baseline fat intake and dietary intervention on melanoma risk warrants further investigation.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-34391","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Stanford School of Medicine.","annee":"2013","mois":"5","numero":"","page":"","auteurs":[{"ID":34389,"post_author":"0","post_date":"2018-12-04 00:28:36","post_date_gmt":"2018-12-03 23:28:36","post_content":"","post_title":"Christina S Gamba","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"christina-s-gamba","to_ping":"","pinged":"","post_modified":"2018-12-04 00:28:36","post_modified_gmt":"2018-12-03 23:28:36","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/christina-s-gamba\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":34390,"post_author":"0","post_date":"2018-12-04 00:28:37","post_date_gmt":"2018-12-03 23:28:37","post_content":"","post_title":"Stefanick","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"stefanick","to_ping":"","pinged":"","post_modified":"2018-12-04 00:28:37","post_modified_gmt":"2018-12-03 23:28:37","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/stefanick\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":8124,"post_author":"0","post_date":"2018-12-03 17:56:40","post_date_gmt":"2018-12-03 16:56:40","post_content":"","post_title":"J M Shikany","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"j-m-shikany","to_ping":"","pinged":"","post_modified":"2018-12-03 17:56:40","post_modified_gmt":"2018-12-03 16:56:40","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/j-m-shikany\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":1195,"post_author":"0","post_date":"2018-12-03 15:57:12","post_date_gmt":"2018-12-03 14:57:12","post_content":"","post_title":"CANCER EPIDEMIOLOGY, BIOMARKERS AND PREVENTION","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"cancer-epidemiology-biomarkers-and-prevention","to_ping":"","pinged":"","post_modified":"2018-12-03 15:57:12","post_modified_gmt":"2018-12-03 14:57:12","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/cancer-epidemiology-biomarkers-and-prevention\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"\nLow fat diet and skin cancer risk: the women's health initiative randomized controlled dietary modification trial - 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