{"id":31757,"date":"2014-09-01T00:00:00","date_gmt":"2018-12-03T22:49:29","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/red-meat-and-fruit-intake-is-prognostic-among-patients-with\/"},"modified":"2018-12-03T23:49:29","modified_gmt":"2018-12-03T22:49:29","slug":"red-meat-and-fruit-intake-is-prognostic-among-patients-with","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/red-meat-and-fruit-intake-is-prognostic-among-patients-with\/","title":{"rendered":"Red meat and fruit intake is prognostic among patients with localized cutaneous melanomas more than 1mm thick."},"content":{"rendered":"

BACKGROUND<\/strong>
\nAs the 10-year mortality for localized cutaneous melanoma more than 1.00mm thick approaches 40% following complete resection, non-therapeutic interventions that can supplement recommended active surveillance are needed. Although guidelines recommending nutrition, physical activity and tobacco cessation for cancer survivors have been published, data describing their associations with melanoma survivorship are lacking.<\/p>\n

METHODS<\/strong>
\nAnalysis of modifiable lifestyle behaviors collected on the 249 cases with melanomas more than 1.00mm thick enrolled in the Connecticut Case-Control Study of Skin Self-Examination study was conducted. Independent associations with melanoma-specific survival were evaluated through Cox proportional hazards modeling adjusting for age, gender, Breslow thickness, ulceration and the presence of microsatellites. Independently significant variables were then combined into a single model and backwards elimination was employed until all remaining variables were significant at p<0.05.<\/p>\n

RESULTS<\/strong>
\nFollowing adjustment for age, Breslow thickness and anatomic site of the index melanoma, daily fruit consumption was associated with improved melanoma-specific survival (HR=0.54; 95% CI: 0.34-0.86) whereas at least weekly red meat consumption was associated with worse outcomes (HR=1.84; 95% CI: 1.02-3.30). Natural red (HR=0.44; 95% CI: 0.22-0.88) or blond (HR=0.52; 95% CI: 0.29-0.94) hair were also favorably prognostic. Higher fish consumption was of borderline significance for improved survival only when considered independently (HR=0.65; 95% CI: 0.40-1.05); no association was seen following adjustment for red meat and fruit consumption (p>0.10).<\/p>\n

CONCLUSIONS<\/strong>
\nDietary choices at the time of diagnosis are associated with melanoma-specific survival in patients with melanomas more than 1.00mm thick. Further validation of our findings in larger cohorts with repeated post-diagnostic measures is warranted to further evaluate whether dietary modification during the survivorship period can improve melanoma-specific survival.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-31757","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Yale Cancer Center, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520-8028, USA; Department of Internal Medicine, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520-8028, USA; Department of Pathology, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520-8028, USA; Department of Chronic Disease Epidemiology, Yale School of Public Health, 60 College Street, New Haven, CT 06520-8034, USA. Electronic address: bonnie.gouldrothberg@yale.edu","annee":"2014","mois":"9","numero":"38:5","page":"599-607","auteurs":[{"ID":31752,"post_author":"0","post_date":"2018-12-03 23:49:26","post_date_gmt":"2018-12-03 22:49:26","post_content":"","post_title":"Bonnie E Gould Rothberg","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"bonnie-e-gould-rothberg","to_ping":"","pinged":"","post_modified":"2018-12-03 23:49:26","post_modified_gmt":"2018-12-03 22:49:26","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/bonnie-e-gould-rothberg\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":31753,"post_author":"0","post_date":"2018-12-03 23:49:27","post_date_gmt":"2018-12-03 22:49:27","post_content":"","post_title":"Kaleigh J Bulloch","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"kaleigh-j-bulloch","to_ping":"","pinged":"","post_modified":"2018-12-03 23:49:27","post_modified_gmt":"2018-12-03 22:49:27","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/kaleigh-j-bulloch\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":31754,"post_author":"0","post_date":"2018-12-03 23:49:27","post_date_gmt":"2018-12-03 22:49:27","post_content":"","post_title":"Judith A Fine","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"judith-a-fine","to_ping":"","pinged":"","post_modified":"2018-12-03 23:49:27","post_modified_gmt":"2018-12-03 22:49:27","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/judith-a-fine\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":31755,"post_author":"0","post_date":"2018-12-03 23:49:28","post_date_gmt":"2018-12-03 22:49:28","post_content":"","post_title":"Raymond L Barnhill","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"raymond-l-barnhill","to_ping":"","pinged":"","post_modified":"2018-12-03 23:49:28","post_modified_gmt":"2018-12-03 22:49:28","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/raymond-l-barnhill\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":31756,"post_author":"0","post_date":"2018-12-03 23:49:29","post_date_gmt":"2018-12-03 22:49:29","post_content":"","post_title":"Marianne Berwick","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"marianne-berwick","to_ping":"","pinged":"","post_modified":"2018-12-03 23:49:29","post_modified_gmt":"2018-12-03 22:49:29","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/marianne-berwick\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":12367,"post_author":"0","post_date":"2018-12-03 18:45:43","post_date_gmt":"2018-12-03 17:45:43","post_content":"","post_title":"Cancer epidemiology","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"cancer-epidemiology","to_ping":"","pinged":"","post_modified":"2018-12-03 18:45:43","post_modified_gmt":"2018-12-03 17:45:43","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/cancer-epidemiology\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"\nRed meat and fruit intake is prognostic among patients with localized cutaneous melanomas more than 1mm thick. - 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