{"id":31746,"date":"2014-08-01T00:00:00","date_gmt":"2018-12-03T22:49:20","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/cruciferous-vegetables-had-variable-effects-on-biomarkers\/"},"modified":"2018-12-03T23:49:20","modified_gmt":"2018-12-03T22:49:20","slug":"cruciferous-vegetables-had-variable-effects-on-biomarkers","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/cruciferous-vegetables-had-variable-effects-on-biomarkers\/","title":{"rendered":"Cruciferous Vegetables Had Variable Effects on Biomarkers of Systemic Inflammation in a Randomized Controlled Trial in Healthy Young Adults."},"content":{"rendered":"

BACKGROUND<\/strong>
\nIsothiocyanates in cruciferous vegetables modulate signaling pathways critical to carcinogenesis, including nuclear factor kappa-light-chain-enhancer of activated B cells (NF-?B), a central regulator of inflammation. Glutathione S-transferase (GST) M1 and GSTT1 metabolize isothiocyanates; genetic variants may result in differences in biologic response.<\/p>\n

OBJECTIVE<\/strong>
\nThe objective of this study was to test whether consumption of cruciferous or cruciferous plus apiaceous vegetables altered serum concentrations of interleukin (IL)-6, IL-8, C-reactive protein (CRP), tumor necrosis factor (TNF) ?, and soluble TNF receptor (sTNFR) I and II, and whether this response was GSTM1\/GSTT1 genotype dependent.<\/p>\n

METHODS<\/strong>
\nIn a randomized crossover trial, healthy men (n = 32) and women (n = 31) aged 20-40 y consumed 4 14-d controlled diets: basal (vegetable-free), single-dose cruciferous (1xC) [7 g vegetables\/kg body weight (BW)], double-dose cruciferous (2xC) (14 g\/kg BW), and cruciferous plus apiaceous (carrot family) (1xC+A) vegetables (7 and 4 g\/kg BW, respectively), with a 21-d washout period between each intervention. Urinary isothiocyanate excretion was also evaluated as a marker of systemic isothiocyanate exposure. Fasting morning blood and urine samples were collected on days 0 and 14 and analyzed.<\/p>\n

RESULTS<\/strong>
\nIL-6 concentrations were significantly lower on day 14 of the 2xC and 1xC+A diets than with the basal diet [-19% (95% CI: -30%, -0.1%) and -20% (95% CI: -31%, -0.7%), respectively]. IL-8 concentrations were higher after the 1xC+A diet (+16%; 95% CI: 4.2%, 35.2%) than after the basal diet. There were no effects of diet on CRP, TNF-?, or sTNFRI or II. There were significant differences between GSTM1-null\/GSTT1+ individuals for several biomarkers in response to 1xC+A compared with basal diets (CRP: -37.8%; 95% CI: -58.0%, -7.4%; IL-6: -48.6%; 95% CI: -49.6%, -12.0%; IL-8: 16.3%; 95% CI: 6.7%, 57.7%) and with the 2xC diet compared with the basal diet (IL-8: -33.2%; 95% CI: -43.0%, -1.4%; sTNFRI: -7.5%; 95% CI: -12.7%, -2.3%). There were no significant reductions in biomarker concentrations in response to diet among GSTM1+\/GSTT1+ or GSTM1-null\/GSTT1-null individuals. Twenty-four-hour urinary isothiocyanate excretion was not associated with any of the inflammation markers overall; however, IL-6 was inversely associated with total isothiocyanate excretion in GSTM1-null\/GSTT1-null individuals (? = -0.12; 95% CI: -0.19, -0.05).<\/p>\n

CONCLUSIONS<\/strong>
\nIn this young, healthy population, consumption of cruciferous and apiaceous vegetables reduced circulating IL-6; however, results for other biomarkers of inflammation were not consistent.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-31746","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA \r\nsnavarro@fhcrc.org","annee":"2014","mois":"8","numero":":","page":"","auteurs":[{"ID":8182,"post_author":"0","post_date":"2018-12-03 17:57:18","post_date_gmt":"2018-12-03 16:57:18","post_content":"","post_title":"Sandi L Navarro","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"sandi-l-navarro","to_ping":"","pinged":"","post_modified":"2018-12-03 17:57:18","post_modified_gmt":"2018-12-03 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