{"id":3118,"date":"2018-01-01T00:00:00","date_gmt":"2018-12-03T16:02:27","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/association-of-cardiovascular-health-level-in-older-age-with\/"},"modified":"2018-12-03T17:02:27","modified_gmt":"2018-12-03T16:02:27","slug":"association-of-cardiovascular-health-level-in-older-age-with","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/association-of-cardiovascular-health-level-in-older-age-with\/","title":{"rendered":"Association of Cardiovascular Health Level in Older Age With Cognitive Decline and Incident Dementia."},"content":{"rendered":"<p style=\"text-align:justify\"><strong>Importance<\/strong><br \/>\nEvidence is limited regarding the relation between cardiovascular health level and dementia risk.<\/p>\n<p style=\"text-align:justify\"><strong>Objective<\/strong><br \/>\nTo investigate the association between cardiovascular health level, defined using the 7-item tool from the American Heart Association (AHA), and risk of dementia and cognitive decline in older persons.<\/p>\n<p style=\"text-align:justify\"><strong>Design, Setting, and Participants<\/strong><br \/>\nPopulation-based cohort study of persons aged 65 years or older from Bordeaux, Dijon, and Montpellier, France, without history of cardiovascular diseases or dementia at baseline who underwent repeated in-person neuropsychological testing (January 1999-July 2016) and systematic detection of incident dementia (date of final follow-up, July 26, 2016).<\/p>\n<p style=\"text-align:justify\"><strong>Exposures<\/strong><br \/>\nThe number of the AHA&#039;s Life&#039;s Simple 7 metrics at recommended optimal level (nonsmoking, body mass index &lt;25, regular physical activity, eating fish twice a week or more and fruits and vegetables at least 3 times a day, cholesterol &lt;200 mg\/dL [untreated], fasting glucose &lt;100 mg\/dL [untreated], and blood pressure &lt;120\/80 mm Hg [untreated]; score range, 0-7) and a global cardiovascular health score (range, 0-14; poor, intermediate, and optimal levels of each metric assigned a value of 0, 1, and 2, respectively).<\/p>\n<p style=\"text-align:justify\"><strong>Main Outcomes and Measures<\/strong><br \/>\nIncident dementia validated by an expert committee and change in a composite score of global cognition (in standard units, with values indicating distance from population means, 0 equal to the mean, and +1 and -1 equal to 1 SD above and below the mean).<\/p>\n<p style=\"text-align:justify\"><strong>Results<\/strong><br \/>\nAmong 6626 participants (mean age, 73.7 years; 4200 women [63.4%]), 2412 (36.5%), 3781 (57.1%), and 433 (6.5%) had 0 to 2, 3 to 4, and 5 to 7 health metrics at optimal levels, respectively, at baseline. Over a mean follow-up duration of 8.5 (range, 0.6-16.6) years, 745 participants had incident adjudicated dementia. Compared with the incidence rate of dementia of 1.76 (95% CI, 1.38-2.15) per 100 person-years among those with 0 or 1 health metrics at optimal levels, the absolute differences in incident dementia rates for 2, 3, 4, 5, and 6 to 7 metrics were, respectively, -0.26 (95% CI, -0.48 to -0.04), -0.59 (95% CI, -0.80 to -0.38), -0.43 (95% CI, -0.65 to -0.21), -0.93 (95% CI, -1.18 to -0.68), and -0.96 (95% CI, -1.37 to -0.56) per 100 person-years. In multivariable models, the hazard ratios for dementia were 0.90 (95% CI, 0.84-0.97) per additional optimal metric and 0.92 (95% CI, 0.89-0.96) per additional point on the global score. Furthermore, the gain in global cognition associated with each additional optimal metric at baseline was 0.031 (95% CI, 0.009-0.053) standard units at inclusion, 0.068 (95% CI, 0.045-0.092) units at year 6, and 0.072 (95% CI, 0.042-0.102) units at year 12.<\/p>\n<p style=\"text-align:justify\"><strong>Conclusions and Relevance<\/strong><br \/>\nIn this cohort of older adults, increased numbers of optimal cardiovascular health metrics and a higher cardiovascular health score were associated with a lower risk of dementia and lower rates of cognitive decline. These findings may support the promotion of cardiovascular health to prevent risk factors associated with cognitive decline and dementia.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-3118","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Universit\u00e9 de Bordeaux, INSERM, Bordeaux Population Health Research Center, Bordeaux, France.","annee":"2018","mois":"0","numero":"320:7","page":"657-664","auteurs":[{"ID":3109,"post_author":"0","post_date":"2018-12-03 17:02:23","post_date_gmt":"2018-12-03 16:02:23","post_content":"","post_title":"Christophe Tzourio","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"christophe-tzourio","to_ping":"","pinged":"","post_modified":"2018-12-03 17:02:23","post_modified_gmt":"2018-12-03 16:02:23","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/christophe-tzourio\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":2181,"post_author":"0","post_date":"2018-12-03 16:53:09","post_date_gmt":"2018-12-03 15:53:09","post_content":"","post_title":"C\u00e9cilia Samieri","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"cecilia-samieri","to_ping":"","pinged":"","post_modified":"2018-12-03 16:53:09","post_modified_gmt":"2018-12-03 15:53:09","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/cecilia-samieri\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3110,"post_author":"0","post_date":"2018-12-03 17:02:24","post_date_gmt":"2018-12-03 16:02:24","post_content":"","post_title":"Catherine Helmer","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"catherine-helmer","to_ping":"","pinged":"","post_modified":"2018-12-03 17:02:24","post_modified_gmt":"2018-12-03 16:02:24","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/catherine-helmer\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3111,"post_author":"0","post_date":"2018-12-03 17:02:24","post_date_gmt":"2018-12-03 16:02:24","post_content":"","post_title":"Jean-Fran\u00e7ois Dartigues","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"jean-francois-dartigues","to_ping":"","pinged":"","post_modified":"2018-12-03 17:02:24","post_modified_gmt":"2018-12-03 16:02:24","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/jean-francois-dartigues\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3112,"post_author":"0","post_date":"2018-12-03 17:02:24","post_date_gmt":"2018-12-03 16:02:24","post_content":"","post_title":"Claudine Berr","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"claudine-berr","to_ping":"","pinged":"","post_modified":"2018-12-03 17:02:24","post_modified_gmt":"2018-12-03 16:02:24","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/claudine-berr\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3113,"post_author":"0","post_date":"2018-12-03 17:02:25","post_date_gmt":"2018-12-03 16:02:25","post_content":"","post_title":"Marie-C\u00e9cile Perier","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"marie-cecile-perier","to_ping":"","pinged":"","post_modified":"2018-12-03 17:02:25","post_modified_gmt":"2018-12-03 16:02:25","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/marie-cecile-perier\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3114,"post_author":"0","post_date":"2018-12-03 17:02:25","post_date_gmt":"2018-12-03 16:02:25","post_content":"","post_title":"Bamba Gaye","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"bamba-gaye","to_ping":"","pinged":"","post_modified":"2018-12-03 17:02:25","post_modified_gmt":"2018-12-03 16:02:25","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/bamba-gaye\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3115,"post_author":"0","post_date":"2018-12-03 17:02:26","post_date_gmt":"2018-12-03 16:02:26","post_content":"","post_title":"C\u00e9cile Proust-Lima","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"cecile-proust-lima","to_ping":"","pinged":"","post_modified":"2018-12-03 17:02:26","post_modified_gmt":"2018-12-03 16:02:26","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/cecile-proust-lima\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3116,"post_author":"0","post_date":"2018-12-03 17:02:26","post_date_gmt":"2018-12-03 16:02:26","post_content":"","post_title":"Jean-Philippe Empana","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"jean-philippe-empana","to_ping":"","pinged":"","post_modified":"2018-12-03 17:02:26","post_modified_gmt":"2018-12-03 16:02:26","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/jean-philippe-empana\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":3117,"post_author":"0","post_date":"2018-12-03 17:02:27","post_date_gmt":"2018-12-03 16:02:27","post_content":"","post_title":"JAMA","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"jama","to_ping":"","pinged":"","post_modified":"2018-12-03 17:02:27","post_modified_gmt":"2018-12-03 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