{"id":30249,"date":"2014-11-01T00:00:00","date_gmt":"2018-12-03T22:29:38","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/the-protective-effect-of-the-mediterranean-diet-on-endothelial\/"},"modified":"2018-12-03T23:29:38","modified_gmt":"2018-12-03T22:29:38","slug":"the-protective-effect-of-the-mediterranean-diet-on-endothelial","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/the-protective-effect-of-the-mediterranean-diet-on-endothelial\/","title":{"rendered":"The protective effect of the Mediterranean diet on endothelial resistance to GLP-1 in type 2 diabetes: a preliminary report."},"content":{"rendered":"<p style=\"text-align: justify\"><strong>Background:<\/strong> In type 2 diabetes, acute hyperglycemia worsens endothelial function and inflammation,while resistance to GLP-1 action occurs. All these phenomena seem to be related to the generation of oxidative stress. A Mediterranean diet, supplemented with olive oil, increases plasma antioxidant capacity, suggesting that its implementation can have a favorable effect on the aforementioned phenomena. In the present study, we test the hypothesis that a Mediterranean diet using olive oil can counteract the effects of acute hyperglycemia and can improve the resistance of the endothelium to GLP-1 action.<\/p>\n<p style=\"text-align: justify\"><strong>Methods: <\/strong>Two groups of type 2 diabetic patients, each consisting of twelve subjects, participated in a randomized trial for three months, following a Mediterranean diet using olive oil or a control low-fat diet. Plasma antioxidant capacity, endothelial function, nitrotyrosine, 8-iso-PGF2a, IL-6 and ICAM-1 levels were evaluated at baseline and at the end of the study. The effect of GLP-1 during a hyperglycemic clamp, was also studied at baseline and at the end of the study.<\/p>\n<p style=\"text-align: justify\"><strong>Results: <\/strong>Compared to the control diet, the Mediterranean diet increased plasma antioxidant capacity and improved basal endothelial function, nitrotyrosine, 8-iso-PGF2a, IL-6 and ICAM-1 levels. The Mediterranean diet also reduced the negative effects of acute hyperglycemia, induced by a hyperglycemic clamp, on endothelial function, nitrotyrosine, 8-iso-PGF2a, IL-6 and ICAM-1 levels. Furthermore, the Mediterranean diet improved the protective action of GLP-1 on endothelial function, nitrotyrosine, 8-iso-PGF2a, IL-6 and ICAM-1 levels, also increasing GLP-1-induced insulin secretion.<\/p>\n<p style=\"text-align: justify\"><strong>Conclusions:<\/strong> These data suggest that the Mediterranean diet, using olive oil, prevents the acute hyperglycemia effect on endothelial function, inflammation and oxidative stress, and improves the action of GLP-1, which may have a favorable effect on the management of type 2 diabetes, particularly for the prevention of cardiovascular disease.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-30249","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Department of Cardiovascular and Metabolic Diseases, IRCCS Gruppo Multimedica, Sesto San Giovanni, MI Italy \r\nAntonio Ceriello, Email: aceriell@clinic.ub.es","annee":"2014","mois":"11","numero":"13:1","page":"140","auteurs":[{"ID":9279,"post_author":"0","post_date":"2018-12-03 18:09:23","post_date_gmt":"2018-12-03 17:09:23","post_content":"","post_title":"Katherine Esposito","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"katherine-esposito","to_ping":"","pinged":"","post_modified":"2018-12-03 18:09:23","post_modified_gmt":"2018-12-03 17:09:23","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/katherine-esposito\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":30240,"post_author":"0","post_date":"2018-12-03 23:29:33","post_date_gmt":"2018-12-03 22:29:33","post_content":"","post_title":"Antonio Ceriello","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"antonio-ceriello","to_ping":"","pinged":"","post_modified":"2018-12-03 23:29:33","post_modified_gmt":"2018-12-03 22:29:33","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/antonio-ceriello\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":30241,"post_author":"0","post_date":"2018-12-03 23:29:34","post_date_gmt":"2018-12-03 22:29:34","post_content":"","post_title":"Lucia La Sala","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"lucia-la-sala","to_ping":"","pinged":"","post_modified":"2018-12-03 23:29:34","post_modified_gmt":"2018-12-03 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Nigris","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"valeria-de-nigris","to_ping":"","pinged":"","post_modified":"2018-12-03 23:29:35","post_modified_gmt":"2018-12-03 22:29:35","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/valeria-de-nigris\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":30244,"post_author":"0","post_date":"2018-12-03 23:29:36","post_date_gmt":"2018-12-03 22:29:36","post_content":"","post_title":"Roberto Testa","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"roberto-testa","to_ping":"","pinged":"","post_modified":"2018-12-03 23:29:36","post_modified_gmt":"2018-12-03 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Rondinelli","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"maurizio-rondinelli","to_ping":"","pinged":"","post_modified":"2018-12-03 23:29:37","post_modified_gmt":"2018-12-03 22:29:37","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/maurizio-rondinelli\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":30247,"post_author":"0","post_date":"2018-12-03 23:29:37","post_date_gmt":"2018-12-03 22:29:37","post_content":"","post_title":"Stefano Genovese","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"stefano-genovese","to_ping":"","pinged":"","post_modified":"2018-12-03 23:29:37","post_modified_gmt":"2018-12-03 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