{"id":28972,"date":"2015-02-01T00:00:00","date_gmt":"2018-12-03T22:12:45","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/genetic-studies-of-body-mass-index-yield-new-insights-for-obesity\/"},"modified":"2018-12-03T23:12:45","modified_gmt":"2018-12-03T22:12:45","slug":"genetic-studies-of-body-mass-index-yield-new-insights-for-obesity","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/genetic-studies-of-body-mass-index-yield-new-insights-for-obesity\/","title":{"rendered":"Genetic studies of body mass index yield new insights for obesity biology."},"content":{"rendered":"<p style=\"text-align: justify\">Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P&nbsp;&lt;&nbsp;5&nbsp;&times;&nbsp;10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for &sim;2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for &gt;20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion\/action, energy metabolism, lipid biology and adipogenesis.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-28972","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.\r\n","annee":"2015","mois":"2","numero":"518:7538","page":"197-206","auteurs":[{"ID":4643,"post_author":"0","post_date":"2018-12-03 17:19:27","post_date_gmt":"2018-12-03 16:19:27","post_content":"","post_title":"Satu M\u00e4nnist\u00f6","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"satu-mannisto","to_ping":"","pinged":"","post_modified":"2018-12-03 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