{"id":27761,"date":"2015-09-01T00:00:00","date_gmt":"2018-12-03T21:57:25","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/does-mediterranean-diet-reduce-cardiovascular-events-and\/"},"modified":"2018-12-03T22:57:25","modified_gmt":"2018-12-03T21:57:25","slug":"does-mediterranean-diet-reduce-cardiovascular-events-and","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/does-mediterranean-diet-reduce-cardiovascular-events-and\/","title":{"rendered":"Does Mediterranean diet reduce cardiovascular events and oxidative stress in atrial fibrillation?"},"content":{"rendered":"<p style=\"text-align: justify\">Atrial fibrillation (AF) is characterized by enhanced oxidative stress and is complicated by cardiovascular events (CVEs), which are only partially prevented by anticoagulant treatment. The Mediterranean diet (Med-Diet) has a positive effect on atherosclerotic progression. In a prospective cohort of 709 anticoagulated AF patients, adherence to Med-Diet was assessed to investigate whether Med-Diet may reduce CVEs by lowering oxidative stress. The cohort was divided into three groups according to the Med-Diet score: low (0-3 points), medium (4-6 points), and high (7-9 points) adherence. During a mean follow-up of 39.9 months (2604.8 patients\/year), we registered 72 (2.8%\/year) CVEs: 23.4% in the low-adherence group, 8.4% in the intermediate-adherence group, and 5.3% in the high-adherence group (p&lt;0.001). There were no differences in time in the therapeutic range among groups. The Med-Diet score was inversely correlated with sNOX2-dp (soluble NOX2-derived peptide; Rs: -0.297, p&lt;0.001) and F2-isoprostanes (F2-IsoP; Rs: -0.411, p&lt;0.001). Median values of sNOX2-dp (p&lt;0.001) and F2-IsoP progressively decreased across groups (p&lt;0.001). A Cox regression analysis showed that the Med-Diet score (HR: 0.771, p=0.001), F2-IsoP (HR: 1.002, p=0.004), and heart failure (HR: 1.876, p=0.024) predicted CVEs. In conclusion, these findings raise the hypothesis that adherence to Med-Diet could be associated with a reduction of CVEs, through an antioxidant effect, as shown by a concomitant downregulation of Nox2 and decreased excretion of F2-IsoP.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-27761","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Sapienza University of Rome, Rome, Italy ; daniele.pastori@uniroma1.it","annee":"2015","mois":"9","numero":"23:8","page":"682-7","auteurs":[{"ID":9647,"post_author":"0","post_date":"2018-12-03 18:13:32","post_date_gmt":"2018-12-03 17:13:32","post_content":"","post_title":"Daniele Pastori","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"daniele-pastori","to_ping":"","pinged":"","post_modified":"2018-12-03 18:13:32","post_modified_gmt":"2018-12-03 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Violi","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"francesco-violi","to_ping":"","pinged":"","post_modified":"2018-12-03 18:13:34","post_modified_gmt":"2018-12-03 17:13:34","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/francesco-violi\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":9651,"post_author":"0","post_date":"2018-12-03 18:13:34","post_date_gmt":"2018-12-03 17:13:34","post_content":"","post_title":"Pasquale Pignatelli","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"pasquale-pignatelli","to_ping":"","pinged":"","post_modified":"2018-12-03 18:13:34","post_modified_gmt":"2018-12-03 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